Risk of depression after diagnostic prostate cancer workup – A nationwide, registry-based study
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Risk of depression after diagnostic prostate cancer workup – A nationwide, registry-based study. / Friberg, Anne Sofie; Brasso, Klaus; Larsen, Signe Benzon; Andersen, Elisabeth Wreford; Krøyer, Anja; Helgstrand, John Thomas; Røder, Martin Andreas; Klemann, Nina; Kessing, Lars Vedel; Johansen, Christoffer; Dalton, Susanne Oksbjerg.
In: Psycho-Oncology, Vol. 30, No. 11, 2021, p. 1939-1947.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Risk of depression after diagnostic prostate cancer workup – A nationwide, registry-based study
AU - Friberg, Anne Sofie
AU - Brasso, Klaus
AU - Larsen, Signe Benzon
AU - Andersen, Elisabeth Wreford
AU - Krøyer, Anja
AU - Helgstrand, John Thomas
AU - Røder, Martin Andreas
AU - Klemann, Nina
AU - Kessing, Lars Vedel
AU - Johansen, Christoffer
AU - Dalton, Susanne Oksbjerg
N1 - Publisher Copyright: © 2021 John Wiley & Sons Ltd.
PY - 2021
Y1 - 2021
N2 - Objective: To compare the risk of depression after diagnostic workup for prostate cancer (PCa), regardless of the histopathologic outcome, with that of a cancer-free population. Methods: A nationwide cohort of Danish men who had a prostatic biopsy sample in 1998–2011 was identified from the Danish Prostate Cancer Registry and compared to an age-matched cohort from the background population. Men with other cancers, major psychiatric disorder, or prior use of antidepressants were excluded. The risk of depression defined as hospital contact for depression or prescription for antidepressants was determined from cumulative incidence functions and multivariate Cox regression models. Results: Of 54,766 men who underwent diagnostic workup for PCa, benign results were found for 21,418 and PCa was diagnosed in 33,347. During up to 18 years of follow-up, the adjusted hazard of depression was higher in men with PCa than in the background population, with the highest risk in the two years after diagnosis (hazard ratio (HR) 2.77, 95% CI 2.66–2.87). Comorbidity and lowest or highest income were significant risk factors for depression and the cumulative incidence was substantially higher in men with metastatic or high-risk disease. In men with benign histopathology the HR for depression was 1.22 (95% CI 1.14–1.31) in the first two years but no different from the background population after that. Conclusions: Diagnostic workup for PCa is associated with an increased risk of depression, mainly among men with a diagnosis of PCa. Clinicians should be aware of depressive symptoms in prostate cancer patients.
AB - Objective: To compare the risk of depression after diagnostic workup for prostate cancer (PCa), regardless of the histopathologic outcome, with that of a cancer-free population. Methods: A nationwide cohort of Danish men who had a prostatic biopsy sample in 1998–2011 was identified from the Danish Prostate Cancer Registry and compared to an age-matched cohort from the background population. Men with other cancers, major psychiatric disorder, or prior use of antidepressants were excluded. The risk of depression defined as hospital contact for depression or prescription for antidepressants was determined from cumulative incidence functions and multivariate Cox regression models. Results: Of 54,766 men who underwent diagnostic workup for PCa, benign results were found for 21,418 and PCa was diagnosed in 33,347. During up to 18 years of follow-up, the adjusted hazard of depression was higher in men with PCa than in the background population, with the highest risk in the two years after diagnosis (hazard ratio (HR) 2.77, 95% CI 2.66–2.87). Comorbidity and lowest or highest income were significant risk factors for depression and the cumulative incidence was substantially higher in men with metastatic or high-risk disease. In men with benign histopathology the HR for depression was 1.22 (95% CI 1.14–1.31) in the first two years but no different from the background population after that. Conclusions: Diagnostic workup for PCa is associated with an increased risk of depression, mainly among men with a diagnosis of PCa. Clinicians should be aware of depressive symptoms in prostate cancer patients.
KW - antidepressant drugs
KW - cancer
KW - cancer survivors
KW - depression
KW - oncology
KW - prostate cancer
KW - psycho-oncology
KW - severe mental disorders
KW - survivorship
KW - transrectal high intensity focused ultrasound
U2 - 10.1002/pon.5766
DO - 10.1002/pon.5766
M3 - Journal article
C2 - 34260790
AN - SCOPUS:85110742960
VL - 30
SP - 1939
EP - 1947
JO - Psycho-Oncology
JF - Psycho-Oncology
SN - 1057-9249
IS - 11
ER -
ID: 275774242