Reprogramming cellular identity during intestinal regeneration

Research

Reprogramming cellular identity during intestinal regeneration

Research output: Contribution to journal › Review › Research › peer-review

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Reprogramming cellular identity during intestinal regeneration. / Larsen, Hjalte L; Jensen, Kim B.

In: Current Opinion in Genetics & Development, Vol. 70, 2021, p. 40-47.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Larsen, HL & Jensen, KB 2021, 'Reprogramming cellular identity during intestinal regeneration', Current Opinion in Genetics & Development, vol. 70, pp. 40-47. https://doi.org/10.1016/j.gde.2021.05.005

APA

Larsen, H. L., & Jensen, K. B. (2021). Reprogramming cellular identity during intestinal regeneration. Current Opinion in Genetics & Development, 70, 40-47. https://doi.org/10.1016/j.gde.2021.05.005

Vancouver

Larsen HL, Jensen KB. Reprogramming cellular identity during intestinal regeneration. Current Opinion in Genetics & Development. 2021;70:40-47. https://doi.org/10.1016/j.gde.2021.05.005

Author

Larsen, Hjalte L ; Jensen, Kim B. / Reprogramming cellular identity during intestinal regeneration. In: Current Opinion in Genetics & Development. 2021 ; Vol. 70. pp. 40-47.

Bibtex

@article{8c6f71b2d5af484ca92563ebc0b66a02,

title = "Reprogramming cellular identity during intestinal regeneration",

abstract = "The intestine is a vital organ mediating absorption of nutrients and water. Following tissue damage, the intestine mounts a remarkable regenerative response by reprogramming cellular identity to facilitate reinstatement of homeostasis. Here we review recent advances within intestinal regenerative biology and the emerging concept of fetal-like reprogramming, in which the adult intestinal epithelium transiently enters a repair-associated state reminiscent of ontologically pre-existing stages. We focus on molecular mechanisms governing reprogramming of cellular identity via epithelial-mesenchymal crosstalk, and how novel approaches in organoid technologies enable identification and characterisation of cell-autonomous repair responses within epithelial cells. Transitioning from the single-cell level to tissue scale, we discuss clonal selection following regeneration and associated pathological repurcussions such as cancer and chronic inflammatory diseases.",

author = "Larsen, {Hjalte L} and Jensen, {Kim B}",

year = "2021",

doi = "10.1016/j.gde.2021.05.005",

language = "English",

volume = "70",

pages = "40--47",

journal = "Current Opinion in Genetics & Development",

issn = "0959-437X",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Reprogramming cellular identity during intestinal regeneration

AU - Larsen, Hjalte L

AU - Jensen, Kim B

PY - 2021

Y1 - 2021

N2 - The intestine is a vital organ mediating absorption of nutrients and water. Following tissue damage, the intestine mounts a remarkable regenerative response by reprogramming cellular identity to facilitate reinstatement of homeostasis. Here we review recent advances within intestinal regenerative biology and the emerging concept of fetal-like reprogramming, in which the adult intestinal epithelium transiently enters a repair-associated state reminiscent of ontologically pre-existing stages. We focus on molecular mechanisms governing reprogramming of cellular identity via epithelial-mesenchymal crosstalk, and how novel approaches in organoid technologies enable identification and characterisation of cell-autonomous repair responses within epithelial cells. Transitioning from the single-cell level to tissue scale, we discuss clonal selection following regeneration and associated pathological repurcussions such as cancer and chronic inflammatory diseases.

AB - The intestine is a vital organ mediating absorption of nutrients and water. Following tissue damage, the intestine mounts a remarkable regenerative response by reprogramming cellular identity to facilitate reinstatement of homeostasis. Here we review recent advances within intestinal regenerative biology and the emerging concept of fetal-like reprogramming, in which the adult intestinal epithelium transiently enters a repair-associated state reminiscent of ontologically pre-existing stages. We focus on molecular mechanisms governing reprogramming of cellular identity via epithelial-mesenchymal crosstalk, and how novel approaches in organoid technologies enable identification and characterisation of cell-autonomous repair responses within epithelial cells. Transitioning from the single-cell level to tissue scale, we discuss clonal selection following regeneration and associated pathological repurcussions such as cancer and chronic inflammatory diseases.

U2 - 10.1016/j.gde.2021.05.005

DO - 10.1016/j.gde.2021.05.005

M3 - Review

C2 - 34062491

VL - 70

SP - 40

EP - 47

JO - Current Opinion in Genetics & Development

JF - Current Opinion in Genetics & Development

SN - 0959-437X

ER -

ID: 271536295