Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester
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Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester. / Hansson, Helle; Minja, Daniel T R; Moeller, Sofie L; Lusingu, John P A; Bygbjerg, Ib C; Yde, Anna-Mathilde; Jensen, Rasmus W; Nag, Sidsel; Msemo, Omari A; Theander, Thor G; Alifrangis, Michael; Schmiegelow, Christentze.
In: The Journal of Infectious Diseases, Vol. 224, No. 9, 2021, p. 1605–1613.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Reduced birth weight caused by sextuple drug resistant Plasmodium falciparum infection in early second trimester
AU - Hansson, Helle
AU - Minja, Daniel T R
AU - Moeller, Sofie L
AU - Lusingu, John P A
AU - Bygbjerg, Ib C
AU - Yde, Anna-Mathilde
AU - Jensen, Rasmus W
AU - Nag, Sidsel
AU - Msemo, Omari A
AU - Theander, Thor G
AU - Alifrangis, Michael
AU - Schmiegelow, Christentze
N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2021
Y1 - 2021
N2 - Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps, particularly the sextuple mutant haplotype threatens the antimalarial effectiveness of sulfadoxine-pyrimethamine as intermittent preventive treatment during pregnancy (IPTp). To explore the impact of sextuple mutant haplotype infections on outcome measures after provision of IPTp-SP, we monitored birth outcomes in women followed from prior to conception or from the first trimester until delivery. Women infected with sextuple haplotypes in early 2 nd trimester specifically, delivered newborns with a lower birth weight (-267g, 95% CI -454; -59, p=0·01) compared to women who did not have malaria during pregnancy and women infected with less SP resistant haplotypes (-461g, 95% CI -877; -44, p=0·03). Thus, sextuple haplotype infections seems to impact the effectiveness of SP for IPTp and directly impact birth outcome by lowering birth weight. Close monitoring and targeted malaria control during early pregnancy is therefore crucial to improve birth outcomes.
AB - Mutations in the Plasmodium falciparum genes Pfdhfr and Pfdhps, particularly the sextuple mutant haplotype threatens the antimalarial effectiveness of sulfadoxine-pyrimethamine as intermittent preventive treatment during pregnancy (IPTp). To explore the impact of sextuple mutant haplotype infections on outcome measures after provision of IPTp-SP, we monitored birth outcomes in women followed from prior to conception or from the first trimester until delivery. Women infected with sextuple haplotypes in early 2 nd trimester specifically, delivered newborns with a lower birth weight (-267g, 95% CI -454; -59, p=0·01) compared to women who did not have malaria during pregnancy and women infected with less SP resistant haplotypes (-461g, 95% CI -877; -44, p=0·03). Thus, sextuple haplotype infections seems to impact the effectiveness of SP for IPTp and directly impact birth outcome by lowering birth weight. Close monitoring and targeted malaria control during early pregnancy is therefore crucial to improve birth outcomes.
U2 - 10.1093/infdis/jiab117
DO - 10.1093/infdis/jiab117
M3 - Journal article
C2 - 33684211
VL - 224
SP - 1605
EP - 1613
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 9
ER -
ID: 257978919