Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia

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Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. / Afzal, Shoaib; Bojesen, Stig E; Nordestgaard, Børge G.

In: Alzheimer's & Dementia, Vol. 10, No. 3, 2014, p. 296-302.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Afzal, S, Bojesen, SE & Nordestgaard, BG 2014, 'Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia', Alzheimer's & Dementia, vol. 10, no. 3, pp. 296-302. https://doi.org/10.1016/j.jalz.2013.05.1765

APA

Afzal, S., Bojesen, S. E., & Nordestgaard, B. G. (2014). Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimer's & Dementia, 10(3), 296-302. https://doi.org/10.1016/j.jalz.2013.05.1765

Vancouver

Afzal S, Bojesen SE, Nordestgaard BG. Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimer's & Dementia. 2014;10(3):296-302. https://doi.org/10.1016/j.jalz.2013.05.1765

Author

Afzal, Shoaib ; Bojesen, Stig E ; Nordestgaard, Børge G. / Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. In: Alzheimer's & Dementia. 2014 ; Vol. 10, No. 3. pp. 296-302.

Bibtex

@article{6ff357e26437416e91ce2e2864e7f898,

title = "Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia",

abstract = "BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.",

keywords = "Aged, Alzheimer Disease, Blood Chemical Analysis, Dementia, Vascular, Denmark, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Risk, Risk Factors, Vitamin D, Vitamin D Deficiency",

author = "Shoaib Afzal and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G}",

year = "2014",

doi = "10.1016/j.jalz.2013.05.1765",

language = "English",

volume = "10",

pages = "296--302",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia

AU - Afzal, Shoaib

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.

AB - BACKGROUND: Vitamin D deficiency has been implicated as a risk factor for dementia in several cross-sectional studies. We tested the hypothesis that reduced plasma 25-hydroxyvitamin D (25[OH]D) is associated with increased risk of Alzheimer's disease (AD) and vascular dementia in the general population.METHODS: We measured baseline plasma 25(OH)D in 10,186 white individuals from the Danish general population.RESULTS: During 30 years of follow-up, 418 participants developed AD and 92 developed vascular dementia. Multivariable adjusted hazard ratios for AD were 1.25 (95% confidence interval [CI], 0.95-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.29 (95% CI, 1.01-1.66) for less than the 25th seasonally adjusted 25(OH)D percentile vs. more than the 50th seasonally adjusted 25(OH)D percentile. Multivariable adjusted hazard ratios for vascular dementia were 1.22 (95% CI, 0.77-1.91) for 25(OH)D less than 50 nmol/L vs. greater than or equal to 50 nmol/L, and 1.22 (95% CI, 0.79-1.87) for less than or equal to the 50th vs. more than the 50th seasonally adjusted 25(OH)D percentile. Last, multivariable adjusted hazard ratios for the combined end point were 1.28 (95% CI, 1.00-1.64) for 25(OH)D less than 25 nmol/L vs. greater than or equal to 50 nmol/L, and 1.27 (95% CI, 1.01-1.60) for less than the 25th vs. more than the 50th seasonally adjusted 25(OH)D.CONCLUSIONS: We observed an association of reduced plasma 25(OH)D with increased risk of the combined end point of AD and vascular dementia in this prospective cohort study of the general population.

KW - Aged

KW - Alzheimer Disease

KW - Blood Chemical Analysis

KW - Dementia, Vascular

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk

KW - Risk Factors

KW - Vitamin D

KW - Vitamin D Deficiency

U2 - 10.1016/j.jalz.2013.05.1765

DO - 10.1016/j.jalz.2013.05.1765

M3 - Journal article

C2 - 23871764

VL - 10

SP - 296

EP - 302

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 3

ER -

ID: 138501393