Redefining the role of syndecans in C. elegans biology

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Redefining the role of syndecans in C. elegans biology. / Gopal, Sandeep; Couchman, John; Pocock, Roger.

In: Worm, Vol. 5, No. 1, e1142042, 14.04.2016.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gopal, S, Couchman, J & Pocock, R 2016, 'Redefining the role of syndecans in C. elegans biology', Worm, vol. 5, no. 1, e1142042. https://doi.org/10.1080/21624054.2016.1142042

APA

Gopal, S., Couchman, J., & Pocock, R. (2016). Redefining the role of syndecans in C. elegans biology. Worm, 5(1), [e1142042]. https://doi.org/10.1080/21624054.2016.1142042

Vancouver

Gopal S, Couchman J, Pocock R. Redefining the role of syndecans in C. elegans biology. Worm. 2016 Apr 14;5(1). e1142042. https://doi.org/10.1080/21624054.2016.1142042

Author

Gopal, Sandeep ; Couchman, John ; Pocock, Roger. / Redefining the role of syndecans in C. elegans biology. In: Worm. 2016 ; Vol. 5, No. 1.

Bibtex

@article{a1bf943b464b431a98bfcf7b8356eef2,
title = "Redefining the role of syndecans in C. elegans biology",
abstract = "Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium regulation in mammals that is conserved in C. elegans. We concluded that calcium regulation is the basic, evolutionarily conserved role for syndecans, which enables them to be integral for multiple cellular functions.",
author = "Sandeep Gopal and John Couchman and Roger Pocock",
year = "2016",
month = apr,
day = "14",
doi = "10.1080/21624054.2016.1142042",
language = "English",
volume = "5",
journal = "Worm",
issn = "2162-4046",
publisher = "Landes Bioscience",
number = "1",

}

RIS

TY - JOUR

T1 - Redefining the role of syndecans in C. elegans biology

AU - Gopal, Sandeep

AU - Couchman, John

AU - Pocock, Roger

PY - 2016/4/14

Y1 - 2016/4/14

N2 - Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium regulation in mammals that is conserved in C. elegans. We concluded that calcium regulation is the basic, evolutionarily conserved role for syndecans, which enables them to be integral for multiple cellular functions.

AB - Cytosolic calcium is an important factor during fertilization, development and differentiation. Hence, the control of cytosolic calcium levels has been studied extensively for several decades. Numerous calcium channels have been identified and their mechanism of action elucidated. However, the mode of calcium channel regulation remains elusive. Here we discuss our recent findings regarding the role of syndecans in the regulation of cytosolic calcium levels. Syndecans are transmembrane proteoglycans present in both vertebrates and invertebrates that interact with extracellular ligands resulting in the activation of several downstream signaling pathways. We identified a previously unappreciated role of syndecans in cytosolic calcium regulation in mammals that is conserved in C. elegans. We concluded that calcium regulation is the basic, evolutionarily conserved role for syndecans, which enables them to be integral for multiple cellular functions.

U2 - 10.1080/21624054.2016.1142042

DO - 10.1080/21624054.2016.1142042

M3 - Journal article

C2 - 27073736

VL - 5

JO - Worm

JF - Worm

SN - 2162-4046

IS - 1

M1 - e1142042

ER -

ID: 167804920