TY - JOUR

T1 - Rat hair follicle dermal papillae have an extracellular matrix containing basement membrane components.

AU - Couchman, J R

N1 - Keywords: Animals; Basement Membrane; Cells, Cultured; Extracellular Matrix; Fluorescent Antibody Technique; Hair; Rats; Rats, Inbred Strains; Skin

PY - 1986

Y1 - 1986

N2 - Dermal papillae are small mesenchymally derived zones at the bases of hair follicles which have an important role in hair morphogenesis in the embryo and control of the hair growth cycle in postnatal mammals. The cells of the papilla are enmeshed in a dense extracellular matrix which undergoes extensive changes in concert with the hair cycle. Here it is shown that this matrix in anagen pelage follicles of postnatal rats contains an abundance of basement membrane components rather than dermal components such as interstitial collagens. In particular, type IV collagen, laminin, and basement membrane types of chondroitin sulfate and heparan sulfate proteoglycans are present as matrix components. Dermal papilla cells, when initially isolated from adult rat vibrissae and cultured in vitro, retained the potential to synthesize this spectrum of matrix components, but this was gradually lost, to be replaced by synthesis of other components including type I and III collagens. It seems likely therefore that the dermal papilla cells in vivo synthesize a basement membrane type of extracellular matrix, although a contribution from epithelial, and in some cases capillary endothelial, cells cannot be ruled out.

AB - Dermal papillae are small mesenchymally derived zones at the bases of hair follicles which have an important role in hair morphogenesis in the embryo and control of the hair growth cycle in postnatal mammals. The cells of the papilla are enmeshed in a dense extracellular matrix which undergoes extensive changes in concert with the hair cycle. Here it is shown that this matrix in anagen pelage follicles of postnatal rats contains an abundance of basement membrane components rather than dermal components such as interstitial collagens. In particular, type IV collagen, laminin, and basement membrane types of chondroitin sulfate and heparan sulfate proteoglycans are present as matrix components. Dermal papilla cells, when initially isolated from adult rat vibrissae and cultured in vitro, retained the potential to synthesize this spectrum of matrix components, but this was gradually lost, to be replaced by synthesis of other components including type I and III collagens. It seems likely therefore that the dermal papilla cells in vivo synthesize a basement membrane type of extracellular matrix, although a contribution from epithelial, and in some cases capillary endothelial, cells cannot be ruled out.

M3 - Journal article

C2 - 3537150

VL - 87

SP - 762

EP - 767

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 6

ER -