Rapid Prototyping of Miniaturized Powder Mixing Geometries

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Rapid Prototyping of Miniaturized Powder Mixing Geometries. / Svane, Rasmus; Pedersen, Troels; Hirschberg, Cosima; Rantanen, Jukka.

In: Journal of Pharmaceutical Sciences, Vol. 110, No. 7, 2021, p. 2625-2628.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Svane, R, Pedersen, T, Hirschberg, C & Rantanen, J 2021, 'Rapid Prototyping of Miniaturized Powder Mixing Geometries', Journal of Pharmaceutical Sciences, vol. 110, no. 7, pp. 2625-2628. https://doi.org/10.1016/j.xphs.2021.03.019

APA

Svane, R., Pedersen, T., Hirschberg, C., & Rantanen, J. (2021). Rapid Prototyping of Miniaturized Powder Mixing Geometries. Journal of Pharmaceutical Sciences, 110(7), 2625-2628. https://doi.org/10.1016/j.xphs.2021.03.019

Vancouver

Svane R, Pedersen T, Hirschberg C, Rantanen J. Rapid Prototyping of Miniaturized Powder Mixing Geometries. Journal of Pharmaceutical Sciences. 2021;110(7):2625-2628. https://doi.org/10.1016/j.xphs.2021.03.019

Author

Svane, Rasmus ; Pedersen, Troels ; Hirschberg, Cosima ; Rantanen, Jukka. / Rapid Prototyping of Miniaturized Powder Mixing Geometries. In: Journal of Pharmaceutical Sciences. 2021 ; Vol. 110, No. 7. pp. 2625-2628.

Bibtex

@article{1fbe118b19cf4a1ba378c10aaaf77f97,
title = "Rapid Prototyping of Miniaturized Powder Mixing Geometries",
abstract = "Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.",
keywords = "3D printing, Continuous manufacturing, Inline monitoring, Multivariate data analysis, Process analytical technology (PAT), Residence time distribution (RTD)",
author = "Rasmus Svane and Troels Pedersen and Cosima Hirschberg and Jukka Rantanen",
note = "Publisher Copyright: {\textcopyright} 2021 The Authors",
year = "2021",
doi = "10.1016/j.xphs.2021.03.019",
language = "English",
volume = "110",
pages = "2625--2628",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - Rapid Prototyping of Miniaturized Powder Mixing Geometries

AU - Svane, Rasmus

AU - Pedersen, Troels

AU - Hirschberg, Cosima

AU - Rantanen, Jukka

N1 - Publisher Copyright: © 2021 The Authors

PY - 2021

Y1 - 2021

N2 - Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

AB - Continuous manufacturing is an important element of future manufacturing solutions enabling for both high product quality and streamlined development process. The increasing possibilities with computer simulations allow for innovating novel mixing principles applicable for continuous manufacturing. However, these innovative ideas based on simulations need experimental validation. The use of rapid prototyping based on additive manufacturing opens a possibility to evaluate these ideas at a low cost. In this study, a novel powder mixing geometry was prototyped using additive manufacturing and further, interfaced with an in-line near-IR spectrometer allowing for investigating the residence time distribution (RTD) in this geometry.

KW - 3D printing

KW - Continuous manufacturing

KW - Inline monitoring

KW - Multivariate data analysis

KW - Process analytical technology (PAT)

KW - Residence time distribution (RTD)

U2 - 10.1016/j.xphs.2021.03.019

DO - 10.1016/j.xphs.2021.03.019

M3 - Journal article

C2 - 33775671

AN - SCOPUS:85109057218

VL - 110

SP - 2625

EP - 2628

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 7

ER -

ID: 279127580