Rapid interferometric imaging of printed drug laden multilayer structures

Research output: Contribution to journalJournal articleResearchpeer-review


  • srep04020

    Final published version, 854 KB, PDF document

  • Niklas Sandler
  • Ivan Kassamakov
  • Henrik Ehlers
  • Genina, Natalja
  • Tuomo Ylitalo
  • Edward Haeggstrom
The developments in printing technologies allow fabrication of micron-size nano-layered delivery systems to personal specifications. In this study we fabricated layered polymer structures for drug-delivery into a microfluidic channel and aimed to interferometrically assure their topography and adherence to each other. We present a scanning white light interferometer (SWLI) method for quantitative assurance of the topography of the embedded structure. We determined rapidly in non-destructive manner the thickness and roughness of the structures and whether the printed layers containing polymers or/and active pharmaceutical ingredients (API) adhere to each other. This is crucial in order to have predetermined drug release profiles. We also demonstrate non-invasive measurement of a polymer structure in a microfluidic channel. It shown that traceable interferometric 3D microscopy is a viable technique for detailed structural quality assurance of layered drug-delivery systems. The approach can have impact and find use in a much broader setting within and outside life sciences.
Original languageEnglish
JournalScientific Reports
Pages (from-to)4020
Number of pages1
Publication statusPublished - 7 Feb 2014

    Research areas

  • Drug Delivery Systems, Imaging, Three-Dimensional, Individualized Medicine, Individualized Medicine: methods, Interferometry, Interferometry: methods, Microfluidic Analytical Techniques, Microscopy, Interference, Nanostructures, Pharmaceutical Preparations, Pharmaceutical Preparations: chemical synthesis, Polymers, Polymers: chemistry, Printing, Surface Properties

Number of downloads are based on statistics from Google Scholar and www.ku.dk

No data available

ID: 145539243