Psychosocial risk factors for the metabolic syndrome: A prospective cohort study
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Psychosocial risk factors for the metabolic syndrome : A prospective cohort study. / Pedersen, Jolene Masters; Lund, Rikke; Andersen, Ingelise; Clark, Alice Jessie; Prescott, Eva; Rod, Naja Hulvej.
In: International Journal of Cardiology, Vol. 215, 15.07.2016, p. 41-46.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Psychosocial risk factors for the metabolic syndrome
T2 - A prospective cohort study
AU - Pedersen, Jolene Masters
AU - Lund, Rikke
AU - Andersen, Ingelise
AU - Clark, Alice Jessie
AU - Prescott, Eva
AU - Rod, Naja Hulvej
PY - 2016/7/15
Y1 - 2016/7/15
N2 - Background/Objectives: Metabolic deregulations and development of metabolic syndrome may be an important pathway underlying the relationship between stress and cardiovascular disease. We aim to estimate the effect of a comprehensive range of psychosocial factors on the risk of developing metabolic syndrome in men and women.Methods: The study population consisted of 3621 men and women from the Copenhagen City Heart Study who were free of metabolic syndrome at baseline and reexamined after 10 years. The data was analyzed by multivariable logistic regression models adjusted for age, education, income, menopausal status and life style factors.Results: We found major life events in adult life (OR 1.48, 95% CI 0.93 to 2.36) and major life events at work (OR 2.75, 95% CI 1.38 to 5.50), lacking a confidant (OR 1.94, 95% CI 1.07 to 3.53) and dissatisfaction with social network (OR 1.53, 95% CI 1.11 to 2.11) to be risk factors for developing the metabolic syndrome in women, while vital exhaustion (OR 2.09, 95% CI 0.95 to 4.59) and intake of sleep medications (OR 2.54, 95% CI 0.92 to 5.96) may play a more important role in men.Conclusions: Experiencing major life events in work and adult life and/or dysfunctional social networks is a risk factor for metabolic syndrome in women, and stress reactions such as vital exhaustion and intake of sleep medications may play a more important role in the development of metabolic syndrome men.
AB - Background/Objectives: Metabolic deregulations and development of metabolic syndrome may be an important pathway underlying the relationship between stress and cardiovascular disease. We aim to estimate the effect of a comprehensive range of psychosocial factors on the risk of developing metabolic syndrome in men and women.Methods: The study population consisted of 3621 men and women from the Copenhagen City Heart Study who were free of metabolic syndrome at baseline and reexamined after 10 years. The data was analyzed by multivariable logistic regression models adjusted for age, education, income, menopausal status and life style factors.Results: We found major life events in adult life (OR 1.48, 95% CI 0.93 to 2.36) and major life events at work (OR 2.75, 95% CI 1.38 to 5.50), lacking a confidant (OR 1.94, 95% CI 1.07 to 3.53) and dissatisfaction with social network (OR 1.53, 95% CI 1.11 to 2.11) to be risk factors for developing the metabolic syndrome in women, while vital exhaustion (OR 2.09, 95% CI 0.95 to 4.59) and intake of sleep medications (OR 2.54, 95% CI 0.92 to 5.96) may play a more important role in men.Conclusions: Experiencing major life events in work and adult life and/or dysfunctional social networks is a risk factor for metabolic syndrome in women, and stress reactions such as vital exhaustion and intake of sleep medications may play a more important role in the development of metabolic syndrome men.
KW - Stress
KW - Psychosocial factors
KW - Metabolic syndrome
KW - Social network
KW - Major life events
KW - Vital exhaustion
U2 - 10.1016/j.ijcard.2016.04.076
DO - 10.1016/j.ijcard.2016.04.076
M3 - Journal article
C2 - 27107545
VL - 215
SP - 41
EP - 46
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -
ID: 162671868