Pseudomonas aeruginosa Biofilms

Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion

Research output: Contribution to journal › Journal article › Research

Standard

Pseudomonas aeruginosa Biofilms : Mechanisms of Immune Evasion. / Alhede, Maria; Bjarnsholt, Thomas; Givskov, Michael; Alhede, Morten.

In: Advances in Applied Microbiology, Vol. 86, 2014, p. 1-40.

Research output: Contribution to journal › Journal article › Research

Harvard

Alhede, M, Bjarnsholt, T, Givskov, M & Alhede, M 2014, 'Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion', Advances in Applied Microbiology, vol. 86, pp. 1-40. https://doi.org/10.1016/B978-0-12-800262-9.00001-9

APA

Alhede, M., Bjarnsholt, T., Givskov, M., & Alhede, M. (2014). Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion. Advances in Applied Microbiology, 86, 1-40. https://doi.org/10.1016/B978-0-12-800262-9.00001-9

Vancouver

Alhede M, Bjarnsholt T, Givskov M, Alhede M. Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion. Advances in Applied Microbiology. 2014;86:1-40. https://doi.org/10.1016/B978-0-12-800262-9.00001-9

Author

Alhede, Maria ; Bjarnsholt, Thomas ; Givskov, Michael ; Alhede, Morten. / Pseudomonas aeruginosa Biofilms : Mechanisms of Immune Evasion. In: Advances in Applied Microbiology. 2014 ; Vol. 86. pp. 1-40.

Bibtex

@article{fd4094824c734c10b6705b751634162f,

title = "Pseudomonas aeruginosa Biofilms: Mechanisms of Immune Evasion",

abstract = "The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic fibrosis patients. P. aeruginosa is believed to persist in the host organism due to its capacity to form biofilms, which protect the aggregated, biopolymer-embedded bacteria from the detrimental actions of antibiotic treatments and host immunity. A key component in the protection against innate immunity is rhamnolipid, which is a quorum sensing (QS)-regulated virulence factor. QS is a cell-to-cell signaling mechanism used to coordinate expression of virulence and protection of aggregated biofilm cells. Rhamnolipids are known for their ability to cause hemolysis and have been shown to cause lysis of several cellular components of the human immune system, for example, macrophages and polymorphonuclear leukocytes (PMNs). In this chapter, the interplay between P. aeruginosa and the PMNs in chronic infections is discussed with focus on the role of rhamnolipids and extracellular DNA.",

author = "Maria Alhede and Thomas Bjarnsholt and Michael Givskov and Morten Alhede",

year = "2014",

doi = "10.1016/B978-0-12-800262-9.00001-9",

language = "English",

volume = "86",

pages = "1--40",

journal = "Advances in Applied Microbiology",

issn = "0065-2164",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Pseudomonas aeruginosa Biofilms

T2 - Mechanisms of Immune Evasion

AU - Alhede, Maria

AU - Bjarnsholt, Thomas

AU - Givskov, Michael

AU - Alhede, Morten

PY - 2014

Y1 - 2014

N2 - The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic fibrosis patients. P. aeruginosa is believed to persist in the host organism due to its capacity to form biofilms, which protect the aggregated, biopolymer-embedded bacteria from the detrimental actions of antibiotic treatments and host immunity. A key component in the protection against innate immunity is rhamnolipid, which is a quorum sensing (QS)-regulated virulence factor. QS is a cell-to-cell signaling mechanism used to coordinate expression of virulence and protection of aggregated biofilm cells. Rhamnolipids are known for their ability to cause hemolysis and have been shown to cause lysis of several cellular components of the human immune system, for example, macrophages and polymorphonuclear leukocytes (PMNs). In this chapter, the interplay between P. aeruginosa and the PMNs in chronic infections is discussed with focus on the role of rhamnolipids and extracellular DNA.

AB - The opportunistic gram-negative bacterium Pseudomonas aeruginosa is implicated in many chronic infections and is readily isolated from chronic wounds, medical devices, and the lungs of cystic fibrosis patients. P. aeruginosa is believed to persist in the host organism due to its capacity to form biofilms, which protect the aggregated, biopolymer-embedded bacteria from the detrimental actions of antibiotic treatments and host immunity. A key component in the protection against innate immunity is rhamnolipid, which is a quorum sensing (QS)-regulated virulence factor. QS is a cell-to-cell signaling mechanism used to coordinate expression of virulence and protection of aggregated biofilm cells. Rhamnolipids are known for their ability to cause hemolysis and have been shown to cause lysis of several cellular components of the human immune system, for example, macrophages and polymorphonuclear leukocytes (PMNs). In this chapter, the interplay between P. aeruginosa and the PMNs in chronic infections is discussed with focus on the role of rhamnolipids and extracellular DNA.

U2 - 10.1016/B978-0-12-800262-9.00001-9

DO - 10.1016/B978-0-12-800262-9.00001-9

M3 - Journal article

C2 - 24377853

VL - 86

SP - 1

EP - 40

JO - Advances in Applied Microbiology

JF - Advances in Applied Microbiology

SN - 0065-2164

ER -

ID: 96506264