Protein-protein interactions

Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Protein-protein interactions : a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. / Byron, Olwyn; Vestergaard, Bente.

In: Current Opinion in Structural Biology, Vol. 35, 12.2015, p. 76-86.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Byron, O & Vestergaard, B 2015, 'Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches', Current Opinion in Structural Biology, vol. 35, pp. 76-86. https://doi.org/10.1016/j.sbi.2015.09.003

APA

Byron, O., & Vestergaard, B. (2015). Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. Current Opinion in Structural Biology, 35, 76-86. https://doi.org/10.1016/j.sbi.2015.09.003

Vancouver

Byron O, Vestergaard B. Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. Current Opinion in Structural Biology. 2015 Dec;35:76-86. https://doi.org/10.1016/j.sbi.2015.09.003

Author

Byron, Olwyn ; Vestergaard, Bente. / Protein-protein interactions : a supra-structural phenomenon demanding trans-disciplinary biophysical approaches. In: Current Opinion in Structural Biology. 2015 ; Vol. 35. pp. 76-86.

Bibtex

@article{c76fb69f5ed04ab58ca23b01d0f0ad7c,

title = "Protein-protein interactions: a supra-structural phenomenon demanding trans-disciplinary biophysical approaches",

abstract = "Responsive formation of protein:protein interaction (PPI) upon diverse stimuli is a fundament of cellular function. As a consequence, PPIs are complex, adaptive entities, and exist in structurally heterogeneous interplays defined by the energetic states of the free and complexed protomers. The biophysical and structural investigations of PPIs consequently demand hybrid approaches, implementing orthogonal methods and strategies for global data analysis. Currently, impressive developments in hardware and software within several methodologies define a new era for the biostructural community. Data can be obtained at increasing resolution, at relevant time-scales and under increasingly relevant experimental conditions, intricate data are interpreted reliably, and the questions posed and answered grow in complexity. With this review, highlights from the study of PPIs using a multitude of biophysical methods, are reported. The aim is to depict how the elucidation of the interplay of structures requires the interplay of methods.",

author = "Olwyn Byron and Bente Vestergaard",

year = "2015",

month = dec,

doi = "10.1016/j.sbi.2015.09.003",

language = "English",

volume = "35",

pages = "76--86",

journal = "Current Opinion in Structural Biology",

issn = "0959-440X",

publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Protein-protein interactions

T2 - a supra-structural phenomenon demanding trans-disciplinary biophysical approaches

AU - Byron, Olwyn

AU - Vestergaard, Bente

PY - 2015/12

Y1 - 2015/12

N2 - Responsive formation of protein:protein interaction (PPI) upon diverse stimuli is a fundament of cellular function. As a consequence, PPIs are complex, adaptive entities, and exist in structurally heterogeneous interplays defined by the energetic states of the free and complexed protomers. The biophysical and structural investigations of PPIs consequently demand hybrid approaches, implementing orthogonal methods and strategies for global data analysis. Currently, impressive developments in hardware and software within several methodologies define a new era for the biostructural community. Data can be obtained at increasing resolution, at relevant time-scales and under increasingly relevant experimental conditions, intricate data are interpreted reliably, and the questions posed and answered grow in complexity. With this review, highlights from the study of PPIs using a multitude of biophysical methods, are reported. The aim is to depict how the elucidation of the interplay of structures requires the interplay of methods.

AB - Responsive formation of protein:protein interaction (PPI) upon diverse stimuli is a fundament of cellular function. As a consequence, PPIs are complex, adaptive entities, and exist in structurally heterogeneous interplays defined by the energetic states of the free and complexed protomers. The biophysical and structural investigations of PPIs consequently demand hybrid approaches, implementing orthogonal methods and strategies for global data analysis. Currently, impressive developments in hardware and software within several methodologies define a new era for the biostructural community. Data can be obtained at increasing resolution, at relevant time-scales and under increasingly relevant experimental conditions, intricate data are interpreted reliably, and the questions posed and answered grow in complexity. With this review, highlights from the study of PPIs using a multitude of biophysical methods, are reported. The aim is to depict how the elucidation of the interplay of structures requires the interplay of methods.

U2 - 10.1016/j.sbi.2015.09.003

DO - 10.1016/j.sbi.2015.09.003

M3 - Journal article

C2 - 26496626

VL - 35

SP - 76

EP - 86

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

ER -

ID: 161853656