Protective effect of preexisting rotavirus-specific immunoglobulin A against naturally acquired rotavirus infection in children
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Protective effect of preexisting rotavirus-specific immunoglobulin A against naturally acquired rotavirus infection in children. / Hjelt, K; Grauballe, P C; Paerregaard, A; Nielsen, O H; Krasilnikoff, P A.
In: Journal of Medical Virology, Vol. 21, No. 1, 01.1987, p. 39-47.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Protective effect of preexisting rotavirus-specific immunoglobulin A against naturally acquired rotavirus infection in children
AU - Hjelt, K
AU - Grauballe, P C
AU - Paerregaard, A
AU - Nielsen, O H
AU - Krasilnikoff, P A
PY - 1987/1
Y1 - 1987/1
N2 - The preexisting levels of rotavirus IgA and IgG were measured in 225 children aged 6 months to 7 years in November, ie, before the "rotavirus season" from January to April. During the following 6 months, all episodes of acute gastroenteritis (GE) were evaluated clinically according to a score system and feces was examined for rotavirus, pathogenic bacteria, and parasites. Furthermore, rotavirus GE (n = 45) as well as asymptomatic rotavirus infections (n = 29) were diagnosed serologically. The preexisting concentrations of rotavirus IgA and IgG measured by ELISA were similar in these two groups. However, preexisting rotavirus IgA in the group of children who developed rotavirus GE correlated with less severe symptoms. Thus vomiting was found in 24% and 63% of the children with detectable and undetectable rotavirus IgA, respectively (P less than 0.025). Moreover, according to the total symptom score of rotavirus GE, 52% of the children with detectable preexisting rotavirus IgA had mild symptoms compared with only 13% of those with undetectable concentrations (P less than 0.025). Rotavirus IgG did not have any protective effect. Age per se had a protective effect; older age (greater than 1.5 years) was related to mild symptoms. According to previous studies of local and intestinal antibody response to a rotavirus GE, it is suggested that rotavirus IgA in serum reflects the immunological status of the intestine concerning rotavirus. It is recommended that studies of rotavirus vaccines include rotavirus IgA response and its protective effect.
AB - The preexisting levels of rotavirus IgA and IgG were measured in 225 children aged 6 months to 7 years in November, ie, before the "rotavirus season" from January to April. During the following 6 months, all episodes of acute gastroenteritis (GE) were evaluated clinically according to a score system and feces was examined for rotavirus, pathogenic bacteria, and parasites. Furthermore, rotavirus GE (n = 45) as well as asymptomatic rotavirus infections (n = 29) were diagnosed serologically. The preexisting concentrations of rotavirus IgA and IgG measured by ELISA were similar in these two groups. However, preexisting rotavirus IgA in the group of children who developed rotavirus GE correlated with less severe symptoms. Thus vomiting was found in 24% and 63% of the children with detectable and undetectable rotavirus IgA, respectively (P less than 0.025). Moreover, according to the total symptom score of rotavirus GE, 52% of the children with detectable preexisting rotavirus IgA had mild symptoms compared with only 13% of those with undetectable concentrations (P less than 0.025). Rotavirus IgG did not have any protective effect. Age per se had a protective effect; older age (greater than 1.5 years) was related to mild symptoms. According to previous studies of local and intestinal antibody response to a rotavirus GE, it is suggested that rotavirus IgA in serum reflects the immunological status of the intestine concerning rotavirus. It is recommended that studies of rotavirus vaccines include rotavirus IgA response and its protective effect.
KW - Acute Disease
KW - Age Factors
KW - Antibodies, Viral/immunology
KW - Child
KW - Child, Preschool
KW - Diarrhea, Infantile/etiology
KW - Female
KW - Humans
KW - Immunoglobulin A/immunology
KW - Immunoglobulin G/analysis
KW - Infant
KW - Male
KW - Rotavirus/immunology
KW - Rotavirus Infections/immunology
M3 - Journal article
C2 - 3025356
VL - 21
SP - 39
EP - 47
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 0146-6615
IS - 1
ER -
ID: 218730377