Processed foods drive intestinal barrier permeability and microvascular diseases

Research output: Contribution to journal › Journal article › Research › peer-review

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Processed foods drive intestinal barrier permeability and microvascular diseases. / Snelson, Matthew; Tan, Sih Min; Clarke, Rachel E.; De Pasquale, Cassandra; Thallas-Bonke, Vicki; Nguyen, Tuong Vi; Penfold, Sally A.; Harcourt, Brooke E.; Sourris, Karly C.; Lindblom, Runa S.; Ziemann, Mark; Steer, David; El-Osta, Assam; Davies, Michael J.; Donnellan, Leigh; Deo, Permal; Kellow, Nicole J.; Cooper, Mark E.; Woodruff, Trent M.; Mackay, Charles R.; Forbes, Josephine M.; Coughlan, Melinda T.

In: Science Advances, Vol. 7, No. 14, eabe4841, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Snelson, M, Tan, SM, Clarke, RE, De Pasquale, C, Thallas-Bonke, V, Nguyen, TV, Penfold, SA, Harcourt, BE, Sourris, KC, Lindblom, RS, Ziemann, M, Steer, D, El-Osta, A, Davies, MJ, Donnellan, L, Deo, P, Kellow, NJ, Cooper, ME, Woodruff, TM, Mackay, CR, Forbes, JM & Coughlan, MT 2021, 'Processed foods drive intestinal barrier permeability and microvascular diseases', Science Advances, vol. 7, no. 14, eabe4841. https://doi.org/10.1126/sciadv.abe4841

APA

Snelson, M., Tan, S. M., Clarke, R. E., De Pasquale, C., Thallas-Bonke, V., Nguyen, T. V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M., ... Coughlan, M. T. (2021). Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances, 7(14), [eabe4841]. https://doi.org/10.1126/sciadv.abe4841

Vancouver

Snelson M, Tan SM, Clarke RE, De Pasquale C, Thallas-Bonke V, Nguyen TV et al. Processed foods drive intestinal barrier permeability and microvascular diseases. Science Advances. 2021;7(14). eabe4841. https://doi.org/10.1126/sciadv.abe4841

Author

Snelson, Matthew ; Tan, Sih Min ; Clarke, Rachel E. ; De Pasquale, Cassandra ; Thallas-Bonke, Vicki ; Nguyen, Tuong Vi ; Penfold, Sally A. ; Harcourt, Brooke E. ; Sourris, Karly C. ; Lindblom, Runa S. ; Ziemann, Mark ; Steer, David ; El-Osta, Assam ; Davies, Michael J. ; Donnellan, Leigh ; Deo, Permal ; Kellow, Nicole J. ; Cooper, Mark E. ; Woodruff, Trent M. ; Mackay, Charles R. ; Forbes, Josephine M. ; Coughlan, Melinda T. / Processed foods drive intestinal barrier permeability and microvascular diseases. In: Science Advances. 2021 ; Vol. 7, No. 14.

Bibtex

@article{8156f76fd0e740e68cf60bc0a96e8c00,
title = "Processed foods drive intestinal barrier permeability and microvascular diseases",
abstract = "Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resistant starch fiber diet maintained gut barrier integrity and decreased severity of kidney injury via suppression of complement. These results demonstrate mechanisms by which processed foods cause inflammation that leads to chronic disease.",
author = "Matthew Snelson and Tan, {Sih Min} and Clarke, {Rachel E.} and {De Pasquale}, Cassandra and Vicki Thallas-Bonke and Nguyen, {Tuong Vi} and Penfold, {Sally A.} and Harcourt, {Brooke E.} and Sourris, {Karly C.} and Lindblom, {Runa S.} and Mark Ziemann and David Steer and Assam El-Osta and Davies, {Michael J.} and Leigh Donnellan and Permal Deo and Kellow, {Nicole J.} and Cooper, {Mark E.} and Woodruff, {Trent M.} and Mackay, {Charles R.} and Forbes, {Josephine M.} and Coughlan, {Melinda T.}",
year = "2021",
doi = "10.1126/sciadv.abe4841",
language = "English",
volume = "7",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "14",

}

RIS

TY - JOUR

T1 - Processed foods drive intestinal barrier permeability and microvascular diseases

AU - Snelson, Matthew

AU - Tan, Sih Min

AU - Clarke, Rachel E.

AU - De Pasquale, Cassandra

AU - Thallas-Bonke, Vicki

AU - Nguyen, Tuong Vi

AU - Penfold, Sally A.

AU - Harcourt, Brooke E.

AU - Sourris, Karly C.

AU - Lindblom, Runa S.

AU - Ziemann, Mark

AU - Steer, David

AU - El-Osta, Assam

AU - Davies, Michael J.

AU - Donnellan, Leigh

AU - Deo, Permal

AU - Kellow, Nicole J.

AU - Cooper, Mark E.

AU - Woodruff, Trent M.

AU - Mackay, Charles R.

AU - Forbes, Josephine M.

AU - Coughlan, Melinda T.

PY - 2021

Y1 - 2021

N2 - Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resistant starch fiber diet maintained gut barrier integrity and decreased severity of kidney injury via suppression of complement. These results demonstrate mechanisms by which processed foods cause inflammation that leads to chronic disease.

AB - Intake of processed foods has increased markedly over the past decades, coinciding with increased microvascular diseases such as chronic kidney disease (CKD) and diabetes. Here, we show in rodent models that long-term consumption of a processed diet drives intestinal barrier permeability and an increased risk of CKD. Inhibition of the advanced glycation pathway, which generates Maillard reaction products within foods upon thermal processing, reversed kidney injury. Consequently, a processed diet leads to innate immune complement activation and local kidney inflammation and injury via the potent proinflammatory effector molecule complement 5a (C5a). In a mouse model of diabetes, a high resistant starch fiber diet maintained gut barrier integrity and decreased severity of kidney injury via suppression of complement. These results demonstrate mechanisms by which processed foods cause inflammation that leads to chronic disease.

UR - http://www.scopus.com/inward/record.url?scp=85103745629&partnerID=8YFLogxK

U2 - 10.1126/sciadv.abe4841

DO - 10.1126/sciadv.abe4841

M3 - Journal article

C2 - 33789895

AN - SCOPUS:85103745629

VL - 7

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 14

M1 - eabe4841

ER -

ID: 279689163