Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum. / Sander, Camilla; Nielsen, Henrik Stillhof; Søgaard, Susanne Roslev; Støving, Celina; Yang, Mingshi; Jacobsen, Jette; Rantanen, Jukka.

In: International Journal of Pharmaceutics, Vol. 452, No. 1-2, 16.08.2013, p. 434-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Sander, C, Nielsen, HS, Søgaard, SR, Støving, C, Yang, M, Jacobsen, J & Rantanen, J 2013, 'Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum', International Journal of Pharmaceutics, vol. 452, no. 1-2, pp. 434-7. https://doi.org/10.1016/j.ijpharm.2013.04.082

APA

Sander, C., Nielsen, H. S., Søgaard, S. R., Støving, C., Yang, M., Jacobsen, J., & Rantanen, J. (2013). Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum. International Journal of Pharmaceutics, 452(1-2), 434-7. https://doi.org/10.1016/j.ijpharm.2013.04.082

Vancouver

Sander C, Nielsen HS, Søgaard SR, Støving C, Yang M, Jacobsen J et al. Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum. International Journal of Pharmaceutics. 2013 Aug 16;452(1-2):434-7. https://doi.org/10.1016/j.ijpharm.2013.04.082

Author

Sander, Camilla ; Nielsen, Henrik Stillhof ; Søgaard, Susanne Roslev ; Støving, Celina ; Yang, Mingshi ; Jacobsen, Jette ; Rantanen, Jukka. / Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum. In: International Journal of Pharmaceutics. 2013 ; Vol. 452, No. 1-2. pp. 434-7.

Bibtex

@article{bebef18a219e483fab56abddfd266567,
title = "Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum",
abstract = "Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.",
keywords = "Alginates, Chewing Gum, Desiccation, Drug Delivery Systems, Glucuronic Acid, Hexuronic Acids, Mannitol, Methylcellulose, Nicotine, Technology, Pharmaceutical",
author = "Camilla Sander and Nielsen, {Henrik Stillhof} and S{\o}gaard, {Susanne Roslev} and Celina St{\o}ving and Mingshi Yang and Jette Jacobsen and Jukka Rantanen",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = aug,
day = "16",
doi = "10.1016/j.ijpharm.2013.04.082",
language = "English",
volume = "452",
pages = "434--7",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Process development for spray drying of sticky pharmaceuticals; case study of bioadhesive nicotine microparticles for compressed medicated chewing gum

AU - Sander, Camilla

AU - Nielsen, Henrik Stillhof

AU - Søgaard, Susanne Roslev

AU - Støving, Celina

AU - Yang, Mingshi

AU - Jacobsen, Jette

AU - Rantanen, Jukka

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

AB - Spray drying of pharmaceutical compounds with sticky properties is a challenging task and may require substantial time and resources. By including small-scale studies of single droplet drying kinetics a relatively high number of experiments with less material is allowed. This means one can construct a more robust design space according to Quality by Design (QbD) formulation development principles. In the current study we present a case study on the development of spray dried microparticles comprising nicotine bitartrate and hypromellose or alginate polymer, for incorporation into medicated chewing gum. By illustration of initial studies on single droplet drying kinetics, subsequent characterization of microparticles, and final characterization of compressed chewing gum this paper summarizes the entire development process.

KW - Alginates

KW - Chewing Gum

KW - Desiccation

KW - Drug Delivery Systems

KW - Glucuronic Acid

KW - Hexuronic Acids

KW - Mannitol

KW - Methylcellulose

KW - Nicotine

KW - Technology, Pharmaceutical

U2 - 10.1016/j.ijpharm.2013.04.082

DO - 10.1016/j.ijpharm.2013.04.082

M3 - Journal article

C2 - 23684657

VL - 452

SP - 434

EP - 437

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 104836207