Principles of adoptive T cell therapy in cancer

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Adoptive cell therapy (ACT) utilizing either tumor-infiltrating lymphocyte (TIL)-derived T cells or T cells genetically engineered to express tumor recognizing receptors has emerged as a powerful and potentially curative therapy for several cancers. Many ACT-based therapies have recently entered late-phase clinical testing, with several T cell therapies already achieving regulatory approval for the treatment of patients with B cell malignancies. In this review, we briefly outline the principles of adoptively transferred T cells for the treatment of cancer.

Original languageEnglish
JournalSeminars in Immunopathology
Volume41
Issue number1
Pages (from-to)49–58
ISSN1863-2297
DOIs
Publication statusPublished - Jan 2019

    Research areas

  • Adoptive cell therapy, Cancer immunotherapy, Chimeric antigen receptor, T cells, Tumor-infiltrating lymphocytes

ID: 208885873