Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle
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Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle. / Borre, M B; Dziegiel, M; Høgh, B; Pedersen, E; Rieneck, K; Riley, E; Meis, J F; Aikawa, M; Nakamura, K; Harada, M.
In: Molecular and Biochemical Parasitology, Vol. 49, No. 1, 1991, p. 119-31.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Primary structure and localization of a conserved immunogenic Plasmodium falciparum glutamate rich protein (GLURP) expressed in both the preerythrocytic and erythrocytic stages of the vertebrate life cycle
AU - Borre, M B
AU - Dziegiel, M
AU - Høgh, B
AU - Pedersen, E
AU - Rieneck, K
AU - Riley, E
AU - Meis, J F
AU - Aikawa, M
AU - Nakamura, K
AU - Harada, M
N1 - Keywords: Amino Acid Sequence; Animals; Antigens, Protozoan; Base Sequence; Chromosome Mapping; DNA, Protozoan; Erythrocytes; Microscopy, Immunoelectron; Molecular Sequence Data; Plasmodium falciparum; Protozoan Proteins
PY - 1991
Y1 - 1991
N2 - A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.
AB - A gene coding for a 220-kDa glutamate rich protein (GLURP), an exoantigen of Plasmodium falciparum, was isolated and its nucleotide sequence was determined. The deduced amino acid sequence contains 2 repeat regions. The sequence of one of these was shown to be conserved among geographically dispersed isolates, and a fusion protein containing that sequence was able to stimulate B- and T-cells. Antibodies against GLURP stained erythrocytic stages of the parasite as well as the hepatic stage as detected by electron microscopy.
M3 - Journal article
C2 - 1775153
VL - 49
SP - 119
EP - 131
JO - Molecular and Biochemical Parasitology
JF - Molecular and Biochemical Parasitology
SN - 0166-6851
IS - 1
ER -
ID: 18177925