Prevalence of psoriatic arthritis in patients with psoriasis: A systematic review and meta-analysis of observational and clinical studies
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Prevalence of psoriatic arthritis in patients with psoriasis : A systematic review and meta-analysis of observational and clinical studies. / Alinaghi, Farzad; Calov, Monika; Kristensen, Lars Erik; Gladman, Dafna D; Coates, Laura C; Jullien, Denis; Gottlieb, Alice B; Gisondi, Paolo; Wu, Jashin J; Thyssen, Jacob P; Egeberg, Alexander.
In: Journal of the American Academy of Dermatology, Vol. 80, No. 1, 01.2019, p. 251-265.e19.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Prevalence of psoriatic arthritis in patients with psoriasis
T2 - A systematic review and meta-analysis of observational and clinical studies
AU - Alinaghi, Farzad
AU - Calov, Monika
AU - Kristensen, Lars Erik
AU - Gladman, Dafna D
AU - Coates, Laura C
AU - Jullien, Denis
AU - Gottlieb, Alice B
AU - Gisondi, Paolo
AU - Wu, Jashin J
AU - Thyssen, Jacob P
AU - Egeberg, Alexander
N1 - Copyright © 2018 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
PY - 2019/1
Y1 - 2019/1
N2 - BACKGROUND: Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported.OBJECTIVES: To assess the prevalence and incidence of PsA in patients with psoriasis.METHODS: Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of PsA in patients with psoriasis. A proportion meta-analysis was performed to calculate the pooled proportion estimates of PsA in patients with psoriasis.RESULTS: A total of 266 studies examining 976,408 patients with psoriasis were included. Overall, the pooled proportion (95% confidence interval [CI]) of PsA among patients with psoriasis was 19.7% (95% CI, 18.5%-20.9%). In children and adolescents (<18 years of age), the pooled prevalence was 3.3% (95% CI, 2.1%-4.9%). The PsA prevalence was 22.7% (95% CI, 20.6%-25.0%) in European patients with psoriasis, 21.5% (95% CI, 15.4%-28.2%) in South American patients with psoriasis, 19.5% (95% CI, 17.1%-22.1%) in North American patients with psoriasis, 15.5% (95% CI, 0.009%-51.5%) in African patients with psoriasis, and 14.0% (95% CI, 95% CI, 11.7%-16.3%) in Asian patients with psoriasis. The prevalence of PsA was 23.8% (95% CI, 20.1%-27.6%) in studies in which the Classification Criteria for Psoriatic Arthritis were applied. The incidence of PsA among patients with psoriasis ranged from 0.27 to 2.7 per 100 person-years.LIMITATIONS: Between-study heterogeneity may have affected the estimates.CONCLUSIONS: We found that 1 in 4 patients with psoriasis have PsA. With the growing recognition of the Classification Criteria for Psoriatic Arthritis, more homogenous and comparable prevalence estimates are expected to be reported.
AB - BACKGROUND: Wide-ranging prevalence estimates of psoriatic arthritis (PsA) in patients with psoriasis have been reported.OBJECTIVES: To assess the prevalence and incidence of PsA in patients with psoriasis.METHODS: Two authors independently searched 3 databases for studies reporting on the prevalence or incidence of PsA in patients with psoriasis. A proportion meta-analysis was performed to calculate the pooled proportion estimates of PsA in patients with psoriasis.RESULTS: A total of 266 studies examining 976,408 patients with psoriasis were included. Overall, the pooled proportion (95% confidence interval [CI]) of PsA among patients with psoriasis was 19.7% (95% CI, 18.5%-20.9%). In children and adolescents (<18 years of age), the pooled prevalence was 3.3% (95% CI, 2.1%-4.9%). The PsA prevalence was 22.7% (95% CI, 20.6%-25.0%) in European patients with psoriasis, 21.5% (95% CI, 15.4%-28.2%) in South American patients with psoriasis, 19.5% (95% CI, 17.1%-22.1%) in North American patients with psoriasis, 15.5% (95% CI, 0.009%-51.5%) in African patients with psoriasis, and 14.0% (95% CI, 95% CI, 11.7%-16.3%) in Asian patients with psoriasis. The prevalence of PsA was 23.8% (95% CI, 20.1%-27.6%) in studies in which the Classification Criteria for Psoriatic Arthritis were applied. The incidence of PsA among patients with psoriasis ranged from 0.27 to 2.7 per 100 person-years.LIMITATIONS: Between-study heterogeneity may have affected the estimates.CONCLUSIONS: We found that 1 in 4 patients with psoriasis have PsA. With the growing recognition of the Classification Criteria for Psoriatic Arthritis, more homogenous and comparable prevalence estimates are expected to be reported.
KW - Arthritis, Psoriatic/epidemiology
KW - Clinical Studies as Topic
KW - Humans
KW - Observational Studies as Topic
KW - Prevalence
KW - Psoriasis/complications
U2 - 10.1016/j.jaad.2018.06.027
DO - 10.1016/j.jaad.2018.06.027
M3 - Review
C2 - 29928910
VL - 80
SP - 251-265.e19
JO - American Academy of Dermatology. Journal
JF - American Academy of Dermatology. Journal
SN - 0190-9622
IS - 1
ER -
ID: 235914802