Preoperative embolization in surgical treatment of spinal metastases

Preoperative embolization in surgical treatment of spinal metastases: single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Preoperative embolization in surgical treatment of spinal metastases : single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss. / Clausen, Caroline; Dahl, Benny; Frevert, Susanne Christiansen; Hansen, Lars Valentin; Nielsen, Michael Bachmann; Lönn, Lars.

In: Journal of Vascular and Interventional Radiology, Vol. 26, No. 3, 03.2015, p. 402-12.e1.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Clausen, C, Dahl, B, Frevert, SC, Hansen, LV, Nielsen, MB & Lönn, L 2015, 'Preoperative embolization in surgical treatment of spinal metastases: single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss', Journal of Vascular and Interventional Radiology, vol. 26, no. 3, pp. 402-12.e1. https://doi.org/10.1016/j.jvir.2014.11.014

APA

Clausen, C., Dahl, B., Frevert, S. C., Hansen, L. V., Nielsen, M. B., & Lönn, L. (2015). Preoperative embolization in surgical treatment of spinal metastases: single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss. Journal of Vascular and Interventional Radiology, 26(3), 402-12.e1. https://doi.org/10.1016/j.jvir.2014.11.014

Vancouver

Clausen C, Dahl B, Frevert SC, Hansen LV, Nielsen MB, Lönn L. Preoperative embolization in surgical treatment of spinal metastases: single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss. Journal of Vascular and Interventional Radiology. 2015 Mar;26(3):402-12.e1. https://doi.org/10.1016/j.jvir.2014.11.014

Author

Clausen, Caroline ; Dahl, Benny ; Frevert, Susanne Christiansen ; Hansen, Lars Valentin ; Nielsen, Michael Bachmann ; Lönn, Lars. / Preoperative embolization in surgical treatment of spinal metastases : single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss. In: Journal of Vascular and Interventional Radiology. 2015 ; Vol. 26, No. 3. pp. 402-12.e1.

Bibtex

@article{b2a8510d51e247eab1c4d327534086a1,

title = "Preoperative embolization in surgical treatment of spinal metastases: single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss",

abstract = "PURPOSE: To assess whether preoperative transcatheter arterial embolization of spinal metastases reduces blood loss, the need for transfusion with allogeneic red blood cells (RBCs), and surgery time in the surgical treatment of patients with symptomatic metastatic spinal cord compression.MATERIALS AND METHODS: This single-blind, randomized (1:1), controlled, parallel-group, single-center trial was approved by the Danish National Committee on Biomedical Research Ethics and was conducted from May 2011-March 2013. Participants (N = 45) were scheduled for decompression and posterior thoracic/lumbar spinal instrumentation and randomly assigned to either preoperative embolization (n = 23) or a control group (n = 22). The primary outcome was intraoperative blood loss. Secondary outcomes were perioperative blood loss, allogeneic RBC transfusion, and surgery time. Analyses were performed by intention-to-treat.RESULTS: The intention-to-treat analysis included 45 patients. Mean intraoperative blood loss did not differ significantly (P = .270) between the embolization group (618 mL [SD, 282 mL]) and the control group (735 mL [SD, 415 mL]). There was also no significant difference in allogeneic RBC transfusion (P = .243). Surgery time was significantly shorter in the embolization group (P = .031): median 90 minutes (range, 54-252 min) versus 124 minutes (range, 80-183 min). The subanalysis of hypervascular metastases revealed a significant (P = .041) reduction in blood loss in the embolization group: 645 mL (SD, 289 mL) versus 902 mL (SD, 416 mL).CONCLUSIONS: Preoperative embolization in patients with symptomatic spinal metastasis independent of primary tumor diagnosis did not reduce intraoperative blood loss and allogeneic RBC transfusion significantly but did reduce the surgery time. A small reduction of intraoperative blood loss was shown in hypervascular metastases.",

keywords = "Embolization, Therapeutic, Female, Humans, Laminectomy, Male, Middle Aged, Operative Time, Postoperative Hemorrhage, Preoperative Care, Single-Blind Method, Spinal Neoplasms, Treatment Outcome",

author = "Caroline Clausen and Benny Dahl and Frevert, {Susanne Christiansen} and Hansen, {Lars Valentin} and Nielsen, {Michael Bachmann} and Lars L{\"o}nn",

year = "2015",

month = mar,

doi = "10.1016/j.jvir.2014.11.014",

language = "English",

volume = "26",

pages = "402--12.e1",

journal = "Journal of Vascular and Interventional Radiology",

issn = "1051-0443",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Preoperative embolization in surgical treatment of spinal metastases

T2 - single-blind, randomized controlled clinical trial of efficacy in decreasing intraoperative blood loss

AU - Clausen, Caroline

AU - Dahl, Benny

AU - Frevert, Susanne Christiansen

AU - Hansen, Lars Valentin

AU - Nielsen, Michael Bachmann

AU - Lönn, Lars

PY - 2015/3

Y1 - 2015/3

N2 - PURPOSE: To assess whether preoperative transcatheter arterial embolization of spinal metastases reduces blood loss, the need for transfusion with allogeneic red blood cells (RBCs), and surgery time in the surgical treatment of patients with symptomatic metastatic spinal cord compression.MATERIALS AND METHODS: This single-blind, randomized (1:1), controlled, parallel-group, single-center trial was approved by the Danish National Committee on Biomedical Research Ethics and was conducted from May 2011-March 2013. Participants (N = 45) were scheduled for decompression and posterior thoracic/lumbar spinal instrumentation and randomly assigned to either preoperative embolization (n = 23) or a control group (n = 22). The primary outcome was intraoperative blood loss. Secondary outcomes were perioperative blood loss, allogeneic RBC transfusion, and surgery time. Analyses were performed by intention-to-treat.RESULTS: The intention-to-treat analysis included 45 patients. Mean intraoperative blood loss did not differ significantly (P = .270) between the embolization group (618 mL [SD, 282 mL]) and the control group (735 mL [SD, 415 mL]). There was also no significant difference in allogeneic RBC transfusion (P = .243). Surgery time was significantly shorter in the embolization group (P = .031): median 90 minutes (range, 54-252 min) versus 124 minutes (range, 80-183 min). The subanalysis of hypervascular metastases revealed a significant (P = .041) reduction in blood loss in the embolization group: 645 mL (SD, 289 mL) versus 902 mL (SD, 416 mL).CONCLUSIONS: Preoperative embolization in patients with symptomatic spinal metastasis independent of primary tumor diagnosis did not reduce intraoperative blood loss and allogeneic RBC transfusion significantly but did reduce the surgery time. A small reduction of intraoperative blood loss was shown in hypervascular metastases.

AB - PURPOSE: To assess whether preoperative transcatheter arterial embolization of spinal metastases reduces blood loss, the need for transfusion with allogeneic red blood cells (RBCs), and surgery time in the surgical treatment of patients with symptomatic metastatic spinal cord compression.MATERIALS AND METHODS: This single-blind, randomized (1:1), controlled, parallel-group, single-center trial was approved by the Danish National Committee on Biomedical Research Ethics and was conducted from May 2011-March 2013. Participants (N = 45) were scheduled for decompression and posterior thoracic/lumbar spinal instrumentation and randomly assigned to either preoperative embolization (n = 23) or a control group (n = 22). The primary outcome was intraoperative blood loss. Secondary outcomes were perioperative blood loss, allogeneic RBC transfusion, and surgery time. Analyses were performed by intention-to-treat.RESULTS: The intention-to-treat analysis included 45 patients. Mean intraoperative blood loss did not differ significantly (P = .270) between the embolization group (618 mL [SD, 282 mL]) and the control group (735 mL [SD, 415 mL]). There was also no significant difference in allogeneic RBC transfusion (P = .243). Surgery time was significantly shorter in the embolization group (P = .031): median 90 minutes (range, 54-252 min) versus 124 minutes (range, 80-183 min). The subanalysis of hypervascular metastases revealed a significant (P = .041) reduction in blood loss in the embolization group: 645 mL (SD, 289 mL) versus 902 mL (SD, 416 mL).CONCLUSIONS: Preoperative embolization in patients with symptomatic spinal metastasis independent of primary tumor diagnosis did not reduce intraoperative blood loss and allogeneic RBC transfusion significantly but did reduce the surgery time. A small reduction of intraoperative blood loss was shown in hypervascular metastases.

KW - Embolization, Therapeutic

KW - Female

KW - Humans

KW - Laminectomy

KW - Male

KW - Middle Aged

KW - Operative Time

KW - Postoperative Hemorrhage

KW - Preoperative Care

KW - Single-Blind Method

KW - Spinal Neoplasms

KW - Treatment Outcome

U2 - 10.1016/j.jvir.2014.11.014

DO - 10.1016/j.jvir.2014.11.014

M3 - Journal article

C2 - 25636672

VL - 26

SP - 402-12.e1

JO - Journal of Vascular and Interventional Radiology

JF - Journal of Vascular and Interventional Radiology

SN - 1051-0443

IS - 3

ER -

ID: 161731980