Pregnancy duration and breast cancer risk

Research output: Contribution to journal › Journal article › peer-review

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Pregnancy duration and breast cancer risk. / Husby, Anders; Wohlfahrt, Jan; Øyen, Nina; Melbye, Mads.

In: Nature Communications, Vol. 9, No. 1, 4255, 2018, p. 1-7.

Research output: Contribution to journal › Journal article › peer-review

Harvard

Husby, A, Wohlfahrt, J, Øyen, N & Melbye, M 2018, 'Pregnancy duration and breast cancer risk', Nature Communications, vol. 9, no. 1, 4255, pp. 1-7. https://doi.org/10.1038/s41467-018-06748-3

APA

Husby, A., Wohlfahrt, J., Øyen, N., & Melbye, M. (2018). Pregnancy duration and breast cancer risk. Nature Communications, 9(1), 1-7. [4255]. https://doi.org/10.1038/s41467-018-06748-3

Vancouver

Husby A, Wohlfahrt J, Øyen N, Melbye M. Pregnancy duration and breast cancer risk. Nature Communications. 2018;9(1):1-7. 4255. https://doi.org/10.1038/s41467-018-06748-3

Author

Husby, Anders ; Wohlfahrt, Jan ; Øyen, Nina ; Melbye, Mads. / Pregnancy duration and breast cancer risk. In: Nature Communications. 2018 ; Vol. 9, No. 1. pp. 1-7.

Bibtex

@article{5a01d3f33f494e8c8d8d542586bbac5a,
title = "Pregnancy duration and breast cancer risk",
abstract = "Full-term pregnancies reduce a woman{\textquoteright}s long-term breast cancer risk, while abortions have been shown to have no effect. The precise minimal duration of pregnancy necessary to lower a woman{\textquoteright}s breast cancer risk is, however, unknown. Here we provide evidence which point to the protective effect of pregnancy on breast cancer risk arising precisely at the 34th pregnancy week. Using a cohort of 2.3 million Danish women, we found the reduction in breast cancer risk was not observed for pregnancies lasting 33 weeks or less, but restricted to those pregnancies lasting 34 weeks or longer. We further found that parity, socioeconomic status, and vital status of the child at birth did not explain the association, and also replicated our finding in data from 1.6 million women in Norway. We suggest that a distinct biological effect introduced around week 34 of pregnancy holds the key to understand pregnancy-associated breast cancer protection.",
author = "Anders Husby and Jan Wohlfahrt and Nina {\O}yen and Mads Melbye",
year = "2018",
doi = "10.1038/s41467-018-06748-3",
language = "English",
volume = "9",
pages = "1--7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Pregnancy duration and breast cancer risk

AU - Husby, Anders

AU - Wohlfahrt, Jan

AU - Øyen, Nina

AU - Melbye, Mads

PY - 2018

Y1 - 2018

N2 - Full-term pregnancies reduce a woman’s long-term breast cancer risk, while abortions have been shown to have no effect. The precise minimal duration of pregnancy necessary to lower a woman’s breast cancer risk is, however, unknown. Here we provide evidence which point to the protective effect of pregnancy on breast cancer risk arising precisely at the 34th pregnancy week. Using a cohort of 2.3 million Danish women, we found the reduction in breast cancer risk was not observed for pregnancies lasting 33 weeks or less, but restricted to those pregnancies lasting 34 weeks or longer. We further found that parity, socioeconomic status, and vital status of the child at birth did not explain the association, and also replicated our finding in data from 1.6 million women in Norway. We suggest that a distinct biological effect introduced around week 34 of pregnancy holds the key to understand pregnancy-associated breast cancer protection.

AB - Full-term pregnancies reduce a woman’s long-term breast cancer risk, while abortions have been shown to have no effect. The precise minimal duration of pregnancy necessary to lower a woman’s breast cancer risk is, however, unknown. Here we provide evidence which point to the protective effect of pregnancy on breast cancer risk arising precisely at the 34th pregnancy week. Using a cohort of 2.3 million Danish women, we found the reduction in breast cancer risk was not observed for pregnancies lasting 33 weeks or less, but restricted to those pregnancies lasting 34 weeks or longer. We further found that parity, socioeconomic status, and vital status of the child at birth did not explain the association, and also replicated our finding in data from 1.6 million women in Norway. We suggest that a distinct biological effect introduced around week 34 of pregnancy holds the key to understand pregnancy-associated breast cancer protection.

U2 - 10.1038/s41467-018-06748-3

DO - 10.1038/s41467-018-06748-3

M3 - Journal article

C2 - 30353005

AN - SCOPUS:85055461099

VL - 9

SP - 1

EP - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4255

ER -

ID: 215510408