The simplistic, but still influential, idea of a clear-cut boundary between science and politics does not capture the complexities of the ongoing “dialogue between science and politics.” Neither do political scientists live in an ivory tower, nor do they breathe the air of a separate world. However, the relation between political science practitioners and the rest of the world remains knotty. In this contribution we outline the value of a focus on “practical reflexivity” to assist in the dialogue with political practice. Based on proposals from social theory we evaluate six strategies of coping with the dilemmas of engaging with practice. The strategies provide a menu of choice for political scientists, as well as systematization of furthering the discussion on practical reflexivity.