Physical changes of beta-sitosterol crystals in oily suspensions during heating

Research output: Contribution to journalJournal articleResearchpeer-review

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Physical changes of beta-sitosterol crystals in oily suspensions during heating. / von Bonsdorff-Nikander, Anna; Lievonen, Satu; Christiansen, Leena; Karjalainen, Milja; Rantanen, Jukka; Yliruusi, Jouko.

In: AAPS PharmSciTech, Vol. 6, No. 3, 2005, p. E413-20.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

von Bonsdorff-Nikander, A, Lievonen, S, Christiansen, L, Karjalainen, M, Rantanen, J & Yliruusi, J 2005, 'Physical changes of beta-sitosterol crystals in oily suspensions during heating', AAPS PharmSciTech, vol. 6, no. 3, pp. E413-20. https://doi.org/10.1208/pt060351

APA

von Bonsdorff-Nikander, A., Lievonen, S., Christiansen, L., Karjalainen, M., Rantanen, J., & Yliruusi, J. (2005). Physical changes of beta-sitosterol crystals in oily suspensions during heating. AAPS PharmSciTech, 6(3), E413-20. https://doi.org/10.1208/pt060351

Vancouver

von Bonsdorff-Nikander A, Lievonen S, Christiansen L, Karjalainen M, Rantanen J, Yliruusi J. Physical changes of beta-sitosterol crystals in oily suspensions during heating. AAPS PharmSciTech. 2005;6(3):E413-20. https://doi.org/10.1208/pt060351

Author

von Bonsdorff-Nikander, Anna ; Lievonen, Satu ; Christiansen, Leena ; Karjalainen, Milja ; Rantanen, Jukka ; Yliruusi, Jouko. / Physical changes of beta-sitosterol crystals in oily suspensions during heating. In: AAPS PharmSciTech. 2005 ; Vol. 6, No. 3. pp. E413-20.

Bibtex

@article{b9a6c699bd814ee3bd405950c6428508,
title = "Physical changes of beta-sitosterol crystals in oily suspensions during heating",
abstract = "The aim of this research was to describe the thermal behavior of beta-sitosterol crystals in oil-suspensions with a focus on the role of water during heating. The suspensions were prepared by recrystallization in order to achieve a microcrystalline particle size. The structural changes together with the mechanical properties of the suspensions during heating were studied by using variable temperature X-ray powder diffractometry (VT-XRPD), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). Hydrated beta-sitosterol crystals in an oil-suspension dehydrated, despite the composition of the suspensions, at low temperatures. At high beta-sitosterol concentration, the monohydrate crystal form changed partially to a hemihydrated form, and when only a small amount of water was initially incorporated, the hemihydrate crystal form dehydrated to a mostly anhydrate crystal form. The released water, which was immiscible in the surrounding oil, caused the recrystallization of hydrated beta-sitosterol during cooling. This procedure indicated a reversible dehydration process. Structural and thermal analysis of beta-sitosterol crystals in suspensions, together with mechanical analysis made it possible to understand various physical changes during heating.",
keywords = "Chemistry, Physical, Crystallization, Hot Temperature, Oils, Physicochemical Phenomena, Sitosterols, Suspensions",
author = "{von Bonsdorff-Nikander}, Anna and Satu Lievonen and Leena Christiansen and Milja Karjalainen and Jukka Rantanen and Jouko Yliruusi",
year = "2005",
doi = "10.1208/pt060351",
language = "English",
volume = "6",
pages = "E413--20",
journal = "A A P S PharmSciTech",
issn = "1530-9932",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Physical changes of beta-sitosterol crystals in oily suspensions during heating

AU - von Bonsdorff-Nikander, Anna

AU - Lievonen, Satu

AU - Christiansen, Leena

AU - Karjalainen, Milja

AU - Rantanen, Jukka

AU - Yliruusi, Jouko

PY - 2005

Y1 - 2005

N2 - The aim of this research was to describe the thermal behavior of beta-sitosterol crystals in oil-suspensions with a focus on the role of water during heating. The suspensions were prepared by recrystallization in order to achieve a microcrystalline particle size. The structural changes together with the mechanical properties of the suspensions during heating were studied by using variable temperature X-ray powder diffractometry (VT-XRPD), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). Hydrated beta-sitosterol crystals in an oil-suspension dehydrated, despite the composition of the suspensions, at low temperatures. At high beta-sitosterol concentration, the monohydrate crystal form changed partially to a hemihydrated form, and when only a small amount of water was initially incorporated, the hemihydrate crystal form dehydrated to a mostly anhydrate crystal form. The released water, which was immiscible in the surrounding oil, caused the recrystallization of hydrated beta-sitosterol during cooling. This procedure indicated a reversible dehydration process. Structural and thermal analysis of beta-sitosterol crystals in suspensions, together with mechanical analysis made it possible to understand various physical changes during heating.

AB - The aim of this research was to describe the thermal behavior of beta-sitosterol crystals in oil-suspensions with a focus on the role of water during heating. The suspensions were prepared by recrystallization in order to achieve a microcrystalline particle size. The structural changes together with the mechanical properties of the suspensions during heating were studied by using variable temperature X-ray powder diffractometry (VT-XRPD), differential scanning calorimetry (DSC), and dynamic mechanical analysis (DMA). Hydrated beta-sitosterol crystals in an oil-suspension dehydrated, despite the composition of the suspensions, at low temperatures. At high beta-sitosterol concentration, the monohydrate crystal form changed partially to a hemihydrated form, and when only a small amount of water was initially incorporated, the hemihydrate crystal form dehydrated to a mostly anhydrate crystal form. The released water, which was immiscible in the surrounding oil, caused the recrystallization of hydrated beta-sitosterol during cooling. This procedure indicated a reversible dehydration process. Structural and thermal analysis of beta-sitosterol crystals in suspensions, together with mechanical analysis made it possible to understand various physical changes during heating.

KW - Chemistry, Physical

KW - Crystallization

KW - Hot Temperature

KW - Oils

KW - Physicochemical Phenomena

KW - Sitosterols

KW - Suspensions

U2 - 10.1208/pt060351

DO - 10.1208/pt060351

M3 - Journal article

C2 - 16353999

VL - 6

SP - E413-20

JO - A A P S PharmSciTech

JF - A A P S PharmSciTech

SN - 1530-9932

IS - 3

ER -

ID: 140621755