Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

Research output: Contribution to journalJournal articlepeer-review

Standard

Parameters of glucose metabolism and the aging brain : a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes. / Akintola, Abimbola A; van den Berg, Annette; Altmann-Schneider, Irmhild; Jansen, Steffy W; van Buchem, Mark A; Slagboom, P Eline; Westendorp, Rudi G; van Heemst, Diana; van der Grond, Jeroen.

In: Age (Omaha), Vol. 37, 74, 08.2015, p. 1-12.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Akintola, AA, van den Berg, A, Altmann-Schneider, I, Jansen, SW, van Buchem, MA, Slagboom, PE, Westendorp, RG, van Heemst, D & van der Grond, J 2015, 'Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes', Age (Omaha), vol. 37, 74, pp. 1-12. https://doi.org/10.1007/s11357-015-9802-0

APA

Akintola, A. A., van den Berg, A., Altmann-Schneider, I., Jansen, S. W., van Buchem, M. A., Slagboom, P. E., Westendorp, R. G., van Heemst, D., & van der Grond, J. (2015). Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes. Age (Omaha), 37, 1-12. [74]. https://doi.org/10.1007/s11357-015-9802-0

Vancouver

Akintola AA, van den Berg A, Altmann-Schneider I, Jansen SW, van Buchem MA, Slagboom PE et al. Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes. Age (Omaha). 2015 Aug;37:1-12. 74. https://doi.org/10.1007/s11357-015-9802-0

Author

Akintola, Abimbola A ; van den Berg, Annette ; Altmann-Schneider, Irmhild ; Jansen, Steffy W ; van Buchem, Mark A ; Slagboom, P Eline ; Westendorp, Rudi G ; van Heemst, Diana ; van der Grond, Jeroen. / Parameters of glucose metabolism and the aging brain : a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes. In: Age (Omaha). 2015 ; Vol. 37. pp. 1-12.

Bibtex

@article{5b85d5c47651419cb9ab59a0d55f1093,
title = "Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes",
abstract = "Given the concurrent, escalating epidemic of diabetes mellitus and neurodegenerative diseases, two age-related disorders, we aimed to understand the relation between parameters of glucose metabolism and indices of pathology in the aging brain. From the Leiden Longevity Study, 132 participants (mean age 66 years) underwent a 2-h oral glucose tolerance test to assess glucose tolerance (fasted and area under the curve (AUC) glucose), insulin sensitivity (fasted and AUC insulin and homeostatic model assessment of insulin sensitivity (HOMA-IS)) and insulin secretion (insulinogenic index). 3-T brain MRI was used to detect macro-structural damage (atrophy, white matter hyper-intensities, infarcts and/or micro-bleeds) and magnetization transfer imaging (MTI) to detect loss of micro-structural homogeneity that remains otherwise invisible on conventional MRI. Macro-structurally, higher fasted glucose was significantly associated with white matter atrophy (P = 0.028). Micro-structurally, decreased magnetization transfer ratio (MTR) peak height in gray matter was associated with higher fasted insulin (P = 0.010), AUCinsulin (P = 0.001), insulinogenic index (P = 0.008) and lower HOMA-IS index (P < 0.001). Similar significant associations were found for white matter. Thus, while higher glucose was associated with macro-structural damage, impaired insulin action was associated more strongly with reduced micro-structural brain parenchymal homogeneity. These findings offer some insight into the association between different parameters of glucose metabolism (impairment of which is characteristic of diabetes mellitus) and brain aging.",
author = "Akintola, {Abimbola A} and {van den Berg}, Annette and Irmhild Altmann-Schneider and Jansen, {Steffy W} and {van Buchem}, {Mark A} and Slagboom, {P Eline} and Westendorp, {Rudi G} and {van Heemst}, Diana and {van der Grond}, Jeroen",
year = "2015",
month = aug,
doi = "10.1007/s11357-015-9802-0",
language = "English",
volume = "37",
pages = "1--12",
journal = "GeroScience",
issn = "0161-9152",
publisher = "Springer Science+Business Media",

}

RIS

TY - JOUR

T1 - Parameters of glucose metabolism and the aging brain

T2 - a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

AU - Akintola, Abimbola A

AU - van den Berg, Annette

AU - Altmann-Schneider, Irmhild

AU - Jansen, Steffy W

AU - van Buchem, Mark A

AU - Slagboom, P Eline

AU - Westendorp, Rudi G

AU - van Heemst, Diana

AU - van der Grond, Jeroen

PY - 2015/8

Y1 - 2015/8

N2 - Given the concurrent, escalating epidemic of diabetes mellitus and neurodegenerative diseases, two age-related disorders, we aimed to understand the relation between parameters of glucose metabolism and indices of pathology in the aging brain. From the Leiden Longevity Study, 132 participants (mean age 66 years) underwent a 2-h oral glucose tolerance test to assess glucose tolerance (fasted and area under the curve (AUC) glucose), insulin sensitivity (fasted and AUC insulin and homeostatic model assessment of insulin sensitivity (HOMA-IS)) and insulin secretion (insulinogenic index). 3-T brain MRI was used to detect macro-structural damage (atrophy, white matter hyper-intensities, infarcts and/or micro-bleeds) and magnetization transfer imaging (MTI) to detect loss of micro-structural homogeneity that remains otherwise invisible on conventional MRI. Macro-structurally, higher fasted glucose was significantly associated with white matter atrophy (P = 0.028). Micro-structurally, decreased magnetization transfer ratio (MTR) peak height in gray matter was associated with higher fasted insulin (P = 0.010), AUCinsulin (P = 0.001), insulinogenic index (P = 0.008) and lower HOMA-IS index (P < 0.001). Similar significant associations were found for white matter. Thus, while higher glucose was associated with macro-structural damage, impaired insulin action was associated more strongly with reduced micro-structural brain parenchymal homogeneity. These findings offer some insight into the association between different parameters of glucose metabolism (impairment of which is characteristic of diabetes mellitus) and brain aging.

AB - Given the concurrent, escalating epidemic of diabetes mellitus and neurodegenerative diseases, two age-related disorders, we aimed to understand the relation between parameters of glucose metabolism and indices of pathology in the aging brain. From the Leiden Longevity Study, 132 participants (mean age 66 years) underwent a 2-h oral glucose tolerance test to assess glucose tolerance (fasted and area under the curve (AUC) glucose), insulin sensitivity (fasted and AUC insulin and homeostatic model assessment of insulin sensitivity (HOMA-IS)) and insulin secretion (insulinogenic index). 3-T brain MRI was used to detect macro-structural damage (atrophy, white matter hyper-intensities, infarcts and/or micro-bleeds) and magnetization transfer imaging (MTI) to detect loss of micro-structural homogeneity that remains otherwise invisible on conventional MRI. Macro-structurally, higher fasted glucose was significantly associated with white matter atrophy (P = 0.028). Micro-structurally, decreased magnetization transfer ratio (MTR) peak height in gray matter was associated with higher fasted insulin (P = 0.010), AUCinsulin (P = 0.001), insulinogenic index (P = 0.008) and lower HOMA-IS index (P < 0.001). Similar significant associations were found for white matter. Thus, while higher glucose was associated with macro-structural damage, impaired insulin action was associated more strongly with reduced micro-structural brain parenchymal homogeneity. These findings offer some insight into the association between different parameters of glucose metabolism (impairment of which is characteristic of diabetes mellitus) and brain aging.

U2 - 10.1007/s11357-015-9802-0

DO - 10.1007/s11357-015-9802-0

M3 - Journal article

C2 - 26178969

VL - 37

SP - 1

EP - 12

JO - GeroScience

JF - GeroScience

SN - 0161-9152

M1 - 74

ER -

ID: 141479777