Osteoclasts prefer aged bone

Research output: Contribution to journalJournal articleResearchpeer-review

  • K Henriksen
  • Diana Julie Leeming
  • I Byrjalsen
  • R H Nielsen
  • M G Sorensen
  • Dziegiel, Morten Hanefeld
  • T John Martin
  • C Christiansen
  • P Qvist
  • M A Karsdal
We investigated whether the age of the bones endogenously exerts control over the bone resorption ability of the osteoclasts, and found that osteoclasts preferentially develop and resorb bone on aged bone. These findings indicate that the bone matrix itself plays a role in targeted remodeling of aged bones.
Original languageEnglish
JournalOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Issue number6
Pages (from-to)751-9
Number of pages9
Publication statusPublished - Jun 2007

    Research areas

  • Acid Phosphatase, Aging, Animals, Bone Remodeling, Bone Resorption, Bone and Bones, Cattle, Cell Adhesion, Cell Differentiation, Cells, Cultured, Collagen Type I, Humans, Isoenzymes, Osteoclasts

ID: 47556609