Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy

Research output: Contribution to journal › Review › Research › peer-review

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Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy. / Guldbrandsen, Kasper F; Hendel, Helle W; Langer, Seppo W; Fischer, Barbara M.

In: Diagnostics, Vol. 7, No. 2, 23, 2017.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Guldbrandsen, KF, Hendel, HW, Langer, SW & Fischer, BM 2017, 'Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy', Diagnostics, vol. 7, no. 2, 23. https://doi.org/10.3390/diagnostics7020023

APA

Guldbrandsen, K. F., Hendel, H. W., Langer, S. W., & Fischer, B. M. (2017). Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy. Diagnostics, 7(2), [23]. https://doi.org/10.3390/diagnostics7020023

Vancouver

Guldbrandsen KF, Hendel HW, Langer SW, Fischer BM. Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy. Diagnostics. 2017;7(2). 23. https://doi.org/10.3390/diagnostics7020023

Author

Guldbrandsen, Kasper F ; Hendel, Helle W ; Langer, Seppo W ; Fischer, Barbara M. / Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy. In: Diagnostics. 2017 ; Vol. 7, No. 2.

Bibtex

@article{72e428ae9f444c8a86781e8b3f6a3c26,
title = "Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy",
abstract = "Immune checkpoint inhibitor therapy (ICT) is a new treatment strategy developed for the treatment of cancer. ICT inhibits pathways known to downregulate the innate immune response to cancer cells. These drugs have been shown to be effective in the treatment of a variety of cancers, including metastatic melanoma and lung cancer. Challenges in response evaluation of patients in ICT have risen as immune related side effects and immune cell infiltration may be confused with progressive disease. Furthermore, the timing of the evaluation scan may be challenged by relatively slow responses. To overcome this, new response criteria for evaluating these patients with morphologic imaging have been proposed. The aim of this paper is to review and discuss the current evidence for the use of molecular imaging, e.g., PET/CT (Positron Emission Tomography/Computer Tomography) with18F-Fluorodeoxyglucoes (FDG) as an alternative imaging method for monitoring patients undergoing ICT. Following the currently available evidence, this review will primarily focus on patients with malignant melanoma.",
author = "Guldbrandsen, {Kasper F} and Hendel, {Helle W} and Langer, {Seppo W} and Fischer, {Barbara M}",
year = "2017",
doi = "10.3390/diagnostics7020023",
language = "English",
volume = "7",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Nuclear Molecular Imaging Strategies in Immune Checkpoint Inhibitor Therapy

AU - Guldbrandsen, Kasper F

AU - Hendel, Helle W

AU - Langer, Seppo W

AU - Fischer, Barbara M

PY - 2017

Y1 - 2017

N2 - Immune checkpoint inhibitor therapy (ICT) is a new treatment strategy developed for the treatment of cancer. ICT inhibits pathways known to downregulate the innate immune response to cancer cells. These drugs have been shown to be effective in the treatment of a variety of cancers, including metastatic melanoma and lung cancer. Challenges in response evaluation of patients in ICT have risen as immune related side effects and immune cell infiltration may be confused with progressive disease. Furthermore, the timing of the evaluation scan may be challenged by relatively slow responses. To overcome this, new response criteria for evaluating these patients with morphologic imaging have been proposed. The aim of this paper is to review and discuss the current evidence for the use of molecular imaging, e.g., PET/CT (Positron Emission Tomography/Computer Tomography) with18F-Fluorodeoxyglucoes (FDG) as an alternative imaging method for monitoring patients undergoing ICT. Following the currently available evidence, this review will primarily focus on patients with malignant melanoma.

AB - Immune checkpoint inhibitor therapy (ICT) is a new treatment strategy developed for the treatment of cancer. ICT inhibits pathways known to downregulate the innate immune response to cancer cells. These drugs have been shown to be effective in the treatment of a variety of cancers, including metastatic melanoma and lung cancer. Challenges in response evaluation of patients in ICT have risen as immune related side effects and immune cell infiltration may be confused with progressive disease. Furthermore, the timing of the evaluation scan may be challenged by relatively slow responses. To overcome this, new response criteria for evaluating these patients with morphologic imaging have been proposed. The aim of this paper is to review and discuss the current evidence for the use of molecular imaging, e.g., PET/CT (Positron Emission Tomography/Computer Tomography) with18F-Fluorodeoxyglucoes (FDG) as an alternative imaging method for monitoring patients undergoing ICT. Following the currently available evidence, this review will primarily focus on patients with malignant melanoma.

U2 - 10.3390/diagnostics7020023

DO - 10.3390/diagnostics7020023

M3 - Review

C2 - 28430133

VL - 7

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 2

M1 - 23

ER -

ID: 194525456