Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa

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Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa. / Ring, Hans Christian; Bay, Lene; Kallenbach, Klaus; Miller, Iben M.; Prens, Errol; Saunte, Ditte M.; Bjarnsholt, Thomas; Jemec, Gregor B. E.

In: Acta Dermato-Venereologica, Vol. 97, No. 2, 02.2017, p. 208-213.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Ring, HC, Bay, L, Kallenbach, K, Miller, IM, Prens, E, Saunte, DM, Bjarnsholt, T & Jemec, GBE 2017, 'Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa', Acta Dermato-Venereologica, vol. 97, no. 2, pp. 208-213. https://doi.org/10.2340/00015555-2503

APA

Ring, H. C., Bay, L., Kallenbach, K., Miller, I. M., Prens, E., Saunte, D. M., ... Jemec, G. B. E. (2017). Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa. Acta Dermato-Venereologica, 97(2), 208-213. https://doi.org/10.2340/00015555-2503

Vancouver

Ring HC, Bay L, Kallenbach K, Miller IM, Prens E, Saunte DM et al. Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa. Acta Dermato-Venereologica. 2017 Feb;97(2):208-213. https://doi.org/10.2340/00015555-2503

Author

Ring, Hans Christian ; Bay, Lene ; Kallenbach, Klaus ; Miller, Iben M. ; Prens, Errol ; Saunte, Ditte M. ; Bjarnsholt, Thomas ; Jemec, Gregor B. E. / Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa. In: Acta Dermato-Venereologica. 2017 ; Vol. 97, No. 2. pp. 208-213.

Bibtex

@article{d00937ced37f445f9c014733015c9eed,
title = "Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa",
abstract = "Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginousregions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesizedthat clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differenceswere found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthycontrols. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced microbiota in patients with HS may play an important role in the early course of the disease.",
keywords = "hidradenitis suppurativa, microbiota, biofilm, preclinical",
author = "Ring, {Hans Christian} and Lene Bay and Klaus Kallenbach and Miller, {Iben M.} and Errol Prens and Saunte, {Ditte M.} and Thomas Bjarnsholt and Jemec, {Gregor B. E.}",
year = "2017",
month = "2",
doi = "10.2340/00015555-2503",
language = "English",
volume = "97",
pages = "208--213",
journal = "Acta Dermatovenereologica",
issn = "0001-5555",
publisher = "Society for the Publication of Acta Dermato - Venereologica",
number = "2",

}

RIS

TY - JOUR

T1 - Normal Skin Microbiota is Altered in Pre-clinical Hidradenitis Suppurativa

AU - Ring, Hans Christian

AU - Bay, Lene

AU - Kallenbach, Klaus

AU - Miller, Iben M.

AU - Prens, Errol

AU - Saunte, Ditte M.

AU - Bjarnsholt, Thomas

AU - Jemec, Gregor B. E.

PY - 2017/2

Y1 - 2017/2

N2 - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginousregions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesizedthat clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differenceswere found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthycontrols. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced microbiota in patients with HS may play an important role in the early course of the disease.

AB - Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined by recurrent nodules, tunnels (sinus tracts) and scarring involving the intertriginousregions. The clinical course of HS is compatible with a biofilm-driven disease, and biofilm has been described in lesional HS skin. We therefore hypothesizedthat clinically unaffected HS skin would also have an increased presence of biofilm compared with that of healthy controls. We conducted a case-control study, investigating the morphology of the axillary skin microbiota. Peptide nucleic acid – fluorescence in situ hybridization probes were used in combination with confocal laser scanning microscopy. Significant differenceswere found in both distribution and quantity of the cutaneous microbiota in clinically non-affected axillary skin of patients with HS compared with healthycontrols. Surprisingly, we detected fewer bacteria and less biofilm in patients with HS. The reduced microbiota in patients with HS may play an important role in the early course of the disease.

KW - hidradenitis suppurativa

KW - microbiota

KW - biofilm

KW - preclinical

U2 - 10.2340/00015555-2503

DO - 10.2340/00015555-2503

M3 - Journal article

C2 - 27377144

VL - 97

SP - 208

EP - 213

JO - Acta Dermatovenereologica

JF - Acta Dermatovenereologica

SN - 0001-5555

IS - 2

ER -

ID: 174662470