Noninvasive antenatal screening for fetal RHD in RhD negative women to guide targeted anti-D prophylaxis
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
RhD negative pregnant women who carry an RhD positive fetus are at risk of immunization against the D antigen, which may result in hemolytic disease of the fetus and the newborn. Predicting the fetal RhD status by noninvasive antenatal screening for the fetal RhD gene (RHD) can guide targeted use of antenatal anti-D prophylaxis. Cell-free fetal DNA is extracted from maternal plasma from RhD negative pregnant women at a gestational age of 25 weeks. A real-time PCR-based detection of two RHD exons enables reliable prediction of the fetal RhD status to determine the administration of antenatal prophylaxis, as well as postnatal prophylaxis.
Original language | English |
---|---|
Title of host publication | Prenatal Diagnosis |
Editors | Brynn Levy |
Number of pages | 13 |
Publisher | Humana Press |
Publication date | 2019 |
Pages | 347-359 |
ISBN (Print) | 978-1-4939-8887-7 |
ISBN (Electronic) | 978-1-4939-8889-1 |
DOIs | |
Publication status | Published - 2019 |
Series | Methods in Molecular Biology |
---|---|
Volume | 1885 |
ISSN | 1064-3745 |
- Antenatal prophylaxis, Anti-D, Cell-free fetal DNA, Hemolytic disease of the fetus and newborn, Noninvasive RHD typing, Real-time PCR
Research areas
ID: 223453130