No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. / Thomsen, Morten Bækgaard; Beekman, J D M; Attevelt, N J M; Takahara, A; Sugiyama, A; Chiba, K; Vos, M A.

In: British Journal of Pharmacology, Vol. 149, No. 8, 12.2006, p. 1039-48.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Thomsen, MB, Beekman, JDM, Attevelt, NJM, Takahara, A, Sugiyama, A, Chiba, K & Vos, MA 2006, 'No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block', British Journal of Pharmacology, vol. 149, no. 8, pp. 1039-48. https://doi.org/10.1038/sj.bjp.0706900

APA

Thomsen, M. B., Beekman, J. D. M., Attevelt, N. J. M., Takahara, A., Sugiyama, A., Chiba, K., & Vos, M. A. (2006). No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. British Journal of Pharmacology, 149(8), 1039-48. https://doi.org/10.1038/sj.bjp.0706900

Vancouver

Thomsen MB, Beekman JDM, Attevelt NJM, Takahara A, Sugiyama A, Chiba K et al. No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. British Journal of Pharmacology. 2006 Dec;149(8):1039-48. https://doi.org/10.1038/sj.bjp.0706900

Author

Thomsen, Morten Bækgaard ; Beekman, J D M ; Attevelt, N J M ; Takahara, A ; Sugiyama, A ; Chiba, K ; Vos, M A. / No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block. In: British Journal of Pharmacology. 2006 ; Vol. 149, No. 8. pp. 1039-48.

Bibtex

@article{289cdbad381049d796f6b6cedc7816ae,
title = "No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block",
abstract = "The therapeutically available quinolone antibiotic moxifloxacin has been used as a positive control for prolonging the QT interval in both clinical and non-clinical studies designed to assess the potential of new drugs to delay cardiac repolarization. Despite moxifloxacin prolonging QT, it has not been shown to cause torsades de pointes arrhythmias (TdP). Azithromycin is a macrolide antibiotic that has rarely been associated, clinically, with cases of proarrhythmia. As there is a lack of clinical data available, the cardiac safety of these drugs was assessed in a TdP-susceptible animal model by evaluating their repolarization and proarrhythmia effects.",
keywords = "Anesthesia, Animals, Anti-Arrhythmia Agents, Anti-Bacterial Agents, Arrhythmias, Cardiac, Aza Compounds, Azithromycin, Dogs, Dose-Response Relationship, Drug, Electric Stimulation, Electroencephalography, Electrophysiology, Heart Block, Heart Rate, Long QT Syndrome, Phenethylamines, Quinolines, Sulfonamides, Torsades de Pointes",
author = "Thomsen, {Morten B{\ae}kgaard} and Beekman, {J D M} and Attevelt, {N J M} and A Takahara and A Sugiyama and K Chiba and Vos, {M A}",
year = "2006",
month = "12",
doi = "10.1038/sj.bjp.0706900",
language = "English",
volume = "149",
pages = "1039--48",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley",
number = "8",

}

RIS

TY - JOUR

T1 - No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block

AU - Thomsen, Morten Bækgaard

AU - Beekman, J D M

AU - Attevelt, N J M

AU - Takahara, A

AU - Sugiyama, A

AU - Chiba, K

AU - Vos, M A

PY - 2006/12

Y1 - 2006/12

N2 - The therapeutically available quinolone antibiotic moxifloxacin has been used as a positive control for prolonging the QT interval in both clinical and non-clinical studies designed to assess the potential of new drugs to delay cardiac repolarization. Despite moxifloxacin prolonging QT, it has not been shown to cause torsades de pointes arrhythmias (TdP). Azithromycin is a macrolide antibiotic that has rarely been associated, clinically, with cases of proarrhythmia. As there is a lack of clinical data available, the cardiac safety of these drugs was assessed in a TdP-susceptible animal model by evaluating their repolarization and proarrhythmia effects.

AB - The therapeutically available quinolone antibiotic moxifloxacin has been used as a positive control for prolonging the QT interval in both clinical and non-clinical studies designed to assess the potential of new drugs to delay cardiac repolarization. Despite moxifloxacin prolonging QT, it has not been shown to cause torsades de pointes arrhythmias (TdP). Azithromycin is a macrolide antibiotic that has rarely been associated, clinically, with cases of proarrhythmia. As there is a lack of clinical data available, the cardiac safety of these drugs was assessed in a TdP-susceptible animal model by evaluating their repolarization and proarrhythmia effects.

KW - Anesthesia

KW - Animals

KW - Anti-Arrhythmia Agents

KW - Anti-Bacterial Agents

KW - Arrhythmias, Cardiac

KW - Aza Compounds

KW - Azithromycin

KW - Dogs

KW - Dose-Response Relationship, Drug

KW - Electric Stimulation

KW - Electroencephalography

KW - Electrophysiology

KW - Heart Block

KW - Heart Rate

KW - Long QT Syndrome

KW - Phenethylamines

KW - Quinolines

KW - Sulfonamides

KW - Torsades de Pointes

U2 - 10.1038/sj.bjp.0706900

DO - 10.1038/sj.bjp.0706900

M3 - Journal article

C2 - 17088870

VL - 149

SP - 1039

EP - 1048

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 8

ER -

ID: 45965543