Nitric oxide is a key molecule in migraine and other vascular headaches

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Nitric oxide is a key molecule in migraine and other vascular headaches. / Olesen, J; Thomsen, L L; Iversen, Helle Klingenberg.

In: Trends in Pharmacological Sciences, Vol. 15, No. 5, 05.1994, p. 149-53.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Olesen, J, Thomsen, LL & Iversen, HK 1994, 'Nitric oxide is a key molecule in migraine and other vascular headaches', Trends in Pharmacological Sciences, vol. 15, no. 5, pp. 149-53.

APA

Olesen, J., Thomsen, L. L., & Iversen, H. K. (1994). Nitric oxide is a key molecule in migraine and other vascular headaches. Trends in Pharmacological Sciences, 15(5), 149-53.

Vancouver

Olesen J, Thomsen LL, Iversen HK. Nitric oxide is a key molecule in migraine and other vascular headaches. Trends in Pharmacological Sciences. 1994 May;15(5):149-53.

Author

Olesen, J ; Thomsen, L L ; Iversen, Helle Klingenberg. / Nitric oxide is a key molecule in migraine and other vascular headaches. In: Trends in Pharmacological Sciences. 1994 ; Vol. 15, No. 5. pp. 149-53.

Bibtex

@article{a1a694f967074bfbb5749f4e384764fb,
title = "Nitric oxide is a key molecule in migraine and other vascular headaches",
abstract = "Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics. At relatively high doses of glyceryl trinitrate, migraine sufferers develop stronger and more migraine-like headaches and more pronounced cerebral arterial dilatation than controls. After the infusion of glyceryl trinitrate, non-migraineurs remain headache-free while migraineurs develop a migraine-like attack. In this review, Jes Olesen, Lars Thomsen and Helle Iversen suggest that migraine may be caused by increased amounts and/or affinity of an enzyme in the NO-triggered cascade of reactions. NO may also be involved in the pathogenesis of other vascular headaches.",
keywords = "Amino Acid Oxidoreductases, Cerebrovascular Circulation, Dose-Response Relationship, Drug, Headache, Histamine, Humans, Migraine Disorders, Nitric Oxide, Nitric Oxide Synthase, Nitroglycerin",
author = "J Olesen and Thomsen, {L L} and Iversen, {Helle Klingenberg}",
year = "1994",
month = may,
language = "English",
volume = "15",
pages = "149--53",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Ltd. * Trends Journals",
number = "5",

}

RIS

TY - JOUR

T1 - Nitric oxide is a key molecule in migraine and other vascular headaches

AU - Olesen, J

AU - Thomsen, L L

AU - Iversen, Helle Klingenberg

PY - 1994/5

Y1 - 1994/5

N2 - Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics. At relatively high doses of glyceryl trinitrate, migraine sufferers develop stronger and more migraine-like headaches and more pronounced cerebral arterial dilatation than controls. After the infusion of glyceryl trinitrate, non-migraineurs remain headache-free while migraineurs develop a migraine-like attack. In this review, Jes Olesen, Lars Thomsen and Helle Iversen suggest that migraine may be caused by increased amounts and/or affinity of an enzyme in the NO-triggered cascade of reactions. NO may also be involved in the pathogenesis of other vascular headaches.

AB - Nitric oxide (NO) may play a key role in migraine and other vascular headaches since glyceryl trinitrate (a donor of NO) and histamine (which probably activates endothelial NO formation) both cause a pulsating dose-dependent headache with several migrainous characteristics. At relatively high doses of glyceryl trinitrate, migraine sufferers develop stronger and more migraine-like headaches and more pronounced cerebral arterial dilatation than controls. After the infusion of glyceryl trinitrate, non-migraineurs remain headache-free while migraineurs develop a migraine-like attack. In this review, Jes Olesen, Lars Thomsen and Helle Iversen suggest that migraine may be caused by increased amounts and/or affinity of an enzyme in the NO-triggered cascade of reactions. NO may also be involved in the pathogenesis of other vascular headaches.

KW - Amino Acid Oxidoreductases

KW - Cerebrovascular Circulation

KW - Dose-Response Relationship, Drug

KW - Headache

KW - Histamine

KW - Humans

KW - Migraine Disorders

KW - Nitric Oxide

KW - Nitric Oxide Synthase

KW - Nitroglycerin

M3 - Journal article

C2 - 7538702

VL - 15

SP - 149

EP - 153

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 5

ER -

ID: 128985471