New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Research output: Contribution to journalReviewpeer-review

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New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary. / Schmauck-Medina, Tomas; Molière, Adrian; Lautrup, Sofie; Zhang, Jianying; Chlopicki, Stefan; Madsen, Helena Borland; Cao, Shuqin; Soendenbroe, Casper; Mansell, Els; Vestergaard, Mark Bitsch; Li, Zhiquan; Shiloh, Yosef; Opresko, Patricia L.; Egly, Jean Marc; Kirkwood, Thomas; Verdin, Eric; Bohr, Vilhelm A.; Cox, Lynne S.; Stevnsner, Tinna; Rasmussen, Lene Juel; Fang, Evandro F.

In: Aging, Vol. 14, No. 16, 2022, p. 6829-6839.

Research output: Contribution to journalReviewpeer-review

Harvard

Schmauck-Medina, T, Molière, A, Lautrup, S, Zhang, J, Chlopicki, S, Madsen, HB, Cao, S, Soendenbroe, C, Mansell, E, Vestergaard, MB, Li, Z, Shiloh, Y, Opresko, PL, Egly, JM, Kirkwood, T, Verdin, E, Bohr, VA, Cox, LS, Stevnsner, T, Rasmussen, LJ & Fang, EF 2022, 'New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary', Aging, vol. 14, no. 16, pp. 6829-6839. https://doi.org/10.18632/aging.204248

APA

Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J. M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T., ... Fang, E. F. (2022). New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary. Aging, 14(16), 6829-6839. https://doi.org/10.18632/aging.204248

Vancouver

Schmauck-Medina T, Molière A, Lautrup S, Zhang J, Chlopicki S, Madsen HB et al. New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary. Aging. 2022;14(16):6829-6839. https://doi.org/10.18632/aging.204248

Author

Schmauck-Medina, Tomas ; Molière, Adrian ; Lautrup, Sofie ; Zhang, Jianying ; Chlopicki, Stefan ; Madsen, Helena Borland ; Cao, Shuqin ; Soendenbroe, Casper ; Mansell, Els ; Vestergaard, Mark Bitsch ; Li, Zhiquan ; Shiloh, Yosef ; Opresko, Patricia L. ; Egly, Jean Marc ; Kirkwood, Thomas ; Verdin, Eric ; Bohr, Vilhelm A. ; Cox, Lynne S. ; Stevnsner, Tinna ; Rasmussen, Lene Juel ; Fang, Evandro F. / New hallmarks of ageing : a 2022 Copenhagen ageing meeting summary. In: Aging. 2022 ; Vol. 14, No. 16. pp. 6829-6839.

Bibtex

@article{f3f31be983564f1d8523386ba5df49a3,
title = "New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary",
abstract = "Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by L{\'o}pez-Ot{\'i}n and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the {\textquoteleft}old{\textquoteright} and {\textquoteleft}new{\textquoteright} hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.",
keywords = "Autophagy, Hallmarks of ageing, Healthspan, Longevity, Neurodegeneration",
author = "Tomas Schmauck-Medina and Adrian Moli{\`e}re and Sofie Lautrup and Jianying Zhang and Stefan Chlopicki and Madsen, {Helena Borland} and Shuqin Cao and Casper Soendenbroe and Els Mansell and Vestergaard, {Mark Bitsch} and Zhiquan Li and Yosef Shiloh and Opresko, {Patricia L.} and Egly, {Jean Marc} and Thomas Kirkwood and Eric Verdin and Bohr, {Vilhelm A.} and Cox, {Lynne S.} and Tinna Stevnsner and Rasmussen, {Lene Juel} and Fang, {Evandro F.}",
note = "Publisher Copyright: {\textcopyright} 2022 Schmauck-Medina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2022",
doi = "10.18632/aging.204248",
language = "English",
volume = "14",
pages = "6829--6839",
journal = "Aging",
issn = "1945-4589",
publisher = "Impact Journals LLC",
number = "16",

}

RIS

TY - JOUR

T1 - New hallmarks of ageing

T2 - a 2022 Copenhagen ageing meeting summary

AU - Schmauck-Medina, Tomas

AU - Molière, Adrian

AU - Lautrup, Sofie

AU - Zhang, Jianying

AU - Chlopicki, Stefan

AU - Madsen, Helena Borland

AU - Cao, Shuqin

AU - Soendenbroe, Casper

AU - Mansell, Els

AU - Vestergaard, Mark Bitsch

AU - Li, Zhiquan

AU - Shiloh, Yosef

AU - Opresko, Patricia L.

AU - Egly, Jean Marc

AU - Kirkwood, Thomas

AU - Verdin, Eric

AU - Bohr, Vilhelm A.

AU - Cox, Lynne S.

AU - Stevnsner, Tinna

AU - Rasmussen, Lene Juel

AU - Fang, Evandro F.

N1 - Publisher Copyright: © 2022 Schmauck-Medina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2022

Y1 - 2022

N2 - Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

AB - Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

KW - Autophagy

KW - Hallmarks of ageing

KW - Healthspan

KW - Longevity

KW - Neurodegeneration

U2 - 10.18632/aging.204248

DO - 10.18632/aging.204248

M3 - Review

C2 - 36040386

AN - SCOPUS:85137298030

VL - 14

SP - 6829

EP - 6839

JO - Aging

JF - Aging

SN - 1945-4589

IS - 16

ER -

ID: 319877700