Natural selection of mitochondria during somatic lifetime promotes healthy aging

Research output: Contribution to journalJournal articlepeer-review

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Natural selection of mitochondria during somatic lifetime promotes healthy aging. / Rodell, Anders; Rasmussen, Lene J; Bergersen, Linda H; Singh, Keshav K; Gjedde, Albert.

In: Frontiers in Neuroenergetics, Vol. 5, 2013, p. 1-6.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rodell, A, Rasmussen, LJ, Bergersen, LH, Singh, KK & Gjedde, A 2013, 'Natural selection of mitochondria during somatic lifetime promotes healthy aging', Frontiers in Neuroenergetics, vol. 5, pp. 1-6. https://doi.org/10.3389/fnene.2013.00007

APA

Rodell, A., Rasmussen, L. J., Bergersen, L. H., Singh, K. K., & Gjedde, A. (2013). Natural selection of mitochondria during somatic lifetime promotes healthy aging. Frontiers in Neuroenergetics, 5, 1-6. https://doi.org/10.3389/fnene.2013.00007

Vancouver

Rodell A, Rasmussen LJ, Bergersen LH, Singh KK, Gjedde A. Natural selection of mitochondria during somatic lifetime promotes healthy aging. Frontiers in Neuroenergetics. 2013;5:1-6. https://doi.org/10.3389/fnene.2013.00007

Author

Rodell, Anders ; Rasmussen, Lene J ; Bergersen, Linda H ; Singh, Keshav K ; Gjedde, Albert. / Natural selection of mitochondria during somatic lifetime promotes healthy aging. In: Frontiers in Neuroenergetics. 2013 ; Vol. 5. pp. 1-6.

Bibtex

@article{389447e11c314a77869ae975f75e5488,
title = "Natural selection of mitochondria during somatic lifetime promotes healthy aging",
abstract = "Stimulation of mitochondrial biogenesis during life-time challenges both eliminates disadvantageous properties and drives adaptive selection of advantageous phenotypic variations. Intermittent fission and fusion of mitochondria provide specific targets for health promotion by brief temporal stressors, interspersed with periods of recovery and biogenesis. For mitochondria, the mechanisms of selection, variability, and heritability, are complicated by interaction of two independent genomes, including the multiple copies of DNA in each mitochondrion, as well as the shared nuclear genome of each cell. The mechanisms of stress-induced fission, followed by recovery-induced fusion and biogenesis, drive the improvement of mitochondrial functions, not only as directed by genotypic variations, but also as enabled by phenotypic diversity. Selective adaptation may explain unresolved aspects of aging, including the health effects of exercise, hypoxic and poisonous preconditioning, and tissue-specific mitochondrial differences. We propose that intermittent purposeful enhancement of mitochondrial biogenesis by stressful episodes with subsequent recovery paradoxically promotes adaptive mitochondrial health and continued healthy aging.",
author = "Anders Rodell and Rasmussen, {Lene J} and Bergersen, {Linda H} and Singh, {Keshav K} and Albert Gjedde",
year = "2013",
doi = "10.3389/fnene.2013.00007",
language = "English",
volume = "5",
pages = "1--6",
journal = "Frontiers in Neuroenergetics",
issn = "1662-6427",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Natural selection of mitochondria during somatic lifetime promotes healthy aging

AU - Rodell, Anders

AU - Rasmussen, Lene J

AU - Bergersen, Linda H

AU - Singh, Keshav K

AU - Gjedde, Albert

PY - 2013

Y1 - 2013

N2 - Stimulation of mitochondrial biogenesis during life-time challenges both eliminates disadvantageous properties and drives adaptive selection of advantageous phenotypic variations. Intermittent fission and fusion of mitochondria provide specific targets for health promotion by brief temporal stressors, interspersed with periods of recovery and biogenesis. For mitochondria, the mechanisms of selection, variability, and heritability, are complicated by interaction of two independent genomes, including the multiple copies of DNA in each mitochondrion, as well as the shared nuclear genome of each cell. The mechanisms of stress-induced fission, followed by recovery-induced fusion and biogenesis, drive the improvement of mitochondrial functions, not only as directed by genotypic variations, but also as enabled by phenotypic diversity. Selective adaptation may explain unresolved aspects of aging, including the health effects of exercise, hypoxic and poisonous preconditioning, and tissue-specific mitochondrial differences. We propose that intermittent purposeful enhancement of mitochondrial biogenesis by stressful episodes with subsequent recovery paradoxically promotes adaptive mitochondrial health and continued healthy aging.

AB - Stimulation of mitochondrial biogenesis during life-time challenges both eliminates disadvantageous properties and drives adaptive selection of advantageous phenotypic variations. Intermittent fission and fusion of mitochondria provide specific targets for health promotion by brief temporal stressors, interspersed with periods of recovery and biogenesis. For mitochondria, the mechanisms of selection, variability, and heritability, are complicated by interaction of two independent genomes, including the multiple copies of DNA in each mitochondrion, as well as the shared nuclear genome of each cell. The mechanisms of stress-induced fission, followed by recovery-induced fusion and biogenesis, drive the improvement of mitochondrial functions, not only as directed by genotypic variations, but also as enabled by phenotypic diversity. Selective adaptation may explain unresolved aspects of aging, including the health effects of exercise, hypoxic and poisonous preconditioning, and tissue-specific mitochondrial differences. We propose that intermittent purposeful enhancement of mitochondrial biogenesis by stressful episodes with subsequent recovery paradoxically promotes adaptive mitochondrial health and continued healthy aging.

U2 - 10.3389/fnene.2013.00007

DO - 10.3389/fnene.2013.00007

M3 - Journal article

C2 - 23964235

VL - 5

SP - 1

EP - 6

JO - Frontiers in Neuroenergetics

JF - Frontiers in Neuroenergetics

SN - 1662-6427

ER -

ID: 96632571