Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

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Standard

Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis. / Kurek, Maksymilian; Carnoy, Matthias; Larsen, Peter E; Nielsen, Line H; Hansen, Ole; Rades, Thomas; Schmid, Silvan; Boisen, Anja.

In: Angewandte Chemie (International ed. in English), Vol. 56, No. 14, 27.03.2017, p. 3901-3905.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kurek, M, Carnoy, M, Larsen, PE, Nielsen, LH, Hansen, O, Rades, T, Schmid, S & Boisen, A 2017, 'Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis', Angewandte Chemie (International ed. in English), vol. 56, no. 14, pp. 3901-3905. https://doi.org/10.1002/anie.201700052

APA

Kurek, M., Carnoy, M., Larsen, P. E., Nielsen, L. H., Hansen, O., Rades, T., Schmid, S., & Boisen, A. (2017). Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis. Angewandte Chemie (International ed. in English), 56(14), 3901-3905. https://doi.org/10.1002/anie.201700052

Vancouver

Kurek M, Carnoy M, Larsen PE, Nielsen LH, Hansen O, Rades T et al. Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis. Angewandte Chemie (International ed. in English). 2017 Mar 27;56(14):3901-3905. https://doi.org/10.1002/anie.201700052

Author

Kurek, Maksymilian ; Carnoy, Matthias ; Larsen, Peter E ; Nielsen, Line H ; Hansen, Ole ; Rades, Thomas ; Schmid, Silvan ; Boisen, Anja. / Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis. In: Angewandte Chemie (International ed. in English). 2017 ; Vol. 56, No. 14. pp. 3901-3905.

Bibtex

@article{54d5956501d4474d8f642fec6d335428,

title = "Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis",

abstract = "Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.",

keywords = "Journal Article",

author = "Maksymilian Kurek and Matthias Carnoy and Larsen, {Peter E} and Nielsen, {Line H} and Ole Hansen and Thomas Rades and Silvan Schmid and Anja Boisen",

note = "{\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2017",

month = mar,

day = "27",

doi = "10.1002/anie.201700052",

language = "English",

volume = "56",

pages = "3901--3905",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",

number = "14",

}

RIS

TY - JOUR

T1 - Nanomechanical Infrared Spectroscopy with Vibrating Filters for Pharmaceutical Analysis

AU - Kurek, Maksymilian

AU - Carnoy, Matthias

AU - Larsen, Peter E

AU - Nielsen, Line H

AU - Hansen, Ole

AU - Rades, Thomas

AU - Schmid, Silvan

AU - Boisen, Anja

PY - 2017/3/27

Y1 - 2017/3/27

N2 - Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.

AB - Standard infrared spectroscopy techniques are well-developed and widely used. However, they typically require milligrams of sample and can involve time-consuming sample preparation. A promising alternative is represented by nanomechanical infrared spectroscopy (NAM-IR) based on the photothermal response of a nanomechanical resonator, which enables the chemical analysis of picograms of analyte directly from a liquid solution in only a few minutes. Herein, we present NAM-IR using perforated membranes (filters). The method was tested with the pharmaceutical compound indomethacin to successfully perform a chemical and morphological analysis on roughly 100 pg of sample. With an absolute estimated sensitivity of 109±15 fg, the presented method is suitable for ultrasensitive vibrational spectroscopy.

KW - Journal Article

U2 - 10.1002/anie.201700052

DO - 10.1002/anie.201700052

M3 - Journal article

C2 - 28266106

VL - 56

SP - 3901

EP - 3905

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 14

ER -

ID: 185437793