N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses

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N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. / Iversen, Helle Klingenberg.

In: Clinical Pharmacology and Therapeutics, Vol. 52, No. 2, 08.1992, p. 125-33.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Iversen, HK 1992, 'N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses', Clinical Pharmacology and Therapeutics, vol. 52, no. 2, pp. 125-33.

APA

Iversen, H. K. (1992). N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clinical Pharmacology and Therapeutics, 52(2), 125-33.

Vancouver

Iversen HK. N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clinical Pharmacology and Therapeutics. 1992 Aug;52(2):125-33.

Author

Iversen, Helle Klingenberg. / N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. In: Clinical Pharmacology and Therapeutics. 1992 ; Vol. 52, No. 2. pp. 125-33.

Bibtex

@article{f35c558022144ac7b880c58c4e825f63,
title = "N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses",
abstract = "The effects of N-acetylcysteine, a sulfhydryl group donor, on nitroglycerin-induced headache and dilation of temporal and radial arteries were investigated in 11 healthy volunteers. Nitroglycerin, 0.06 microgram/kg/min, was infused for 20 minutes immediately after and 120 minutes after pretreatment with N-acetylcysteine (100 mg/kg) or placebo. Arterial diameters were measured with high frequency ultrasound, and pain was scored by use of a previously evaluated 10-point scale. Plasma levels of free (n = 2) and total (n = 11) N-acetylcysteine were determined. N-Acetylcysteine potentiated the headache response (median headache score, 3 versus 1), and the headache retained its vascular characteristics. Temporal artery dilation was also potentiated by N-acetylcysteine, 139% +/- 3% versus 127% +/- 3% of baseline, whereas the radial artery was unaffected. The potentiation was most pronounced after the first nitroglycerin infusion (12% versus 4.5% compared with placebo). A prolonged dilation of the temporal artery was observed only after the first nitroglycerin infusion, when high levels of N-acetylcysteine were present.",
keywords = "Acetylcysteine, Adult, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Drug Synergism, Female, Forearm, Headache, Hemodynamics, Humans, Male, Nitroglycerin, Skull, Temporal Arteries, Time Factors, Vasodilation",
author = "Iversen, {Helle Klingenberg}",
year = "1992",
month = aug,
language = "English",
volume = "52",
pages = "125--33",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "JohnWiley & Sons, Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses

AU - Iversen, Helle Klingenberg

PY - 1992/8

Y1 - 1992/8

N2 - The effects of N-acetylcysteine, a sulfhydryl group donor, on nitroglycerin-induced headache and dilation of temporal and radial arteries were investigated in 11 healthy volunteers. Nitroglycerin, 0.06 microgram/kg/min, was infused for 20 minutes immediately after and 120 minutes after pretreatment with N-acetylcysteine (100 mg/kg) or placebo. Arterial diameters were measured with high frequency ultrasound, and pain was scored by use of a previously evaluated 10-point scale. Plasma levels of free (n = 2) and total (n = 11) N-acetylcysteine were determined. N-Acetylcysteine potentiated the headache response (median headache score, 3 versus 1), and the headache retained its vascular characteristics. Temporal artery dilation was also potentiated by N-acetylcysteine, 139% +/- 3% versus 127% +/- 3% of baseline, whereas the radial artery was unaffected. The potentiation was most pronounced after the first nitroglycerin infusion (12% versus 4.5% compared with placebo). A prolonged dilation of the temporal artery was observed only after the first nitroglycerin infusion, when high levels of N-acetylcysteine were present.

AB - The effects of N-acetylcysteine, a sulfhydryl group donor, on nitroglycerin-induced headache and dilation of temporal and radial arteries were investigated in 11 healthy volunteers. Nitroglycerin, 0.06 microgram/kg/min, was infused for 20 minutes immediately after and 120 minutes after pretreatment with N-acetylcysteine (100 mg/kg) or placebo. Arterial diameters were measured with high frequency ultrasound, and pain was scored by use of a previously evaluated 10-point scale. Plasma levels of free (n = 2) and total (n = 11) N-acetylcysteine were determined. N-Acetylcysteine potentiated the headache response (median headache score, 3 versus 1), and the headache retained its vascular characteristics. Temporal artery dilation was also potentiated by N-acetylcysteine, 139% +/- 3% versus 127% +/- 3% of baseline, whereas the radial artery was unaffected. The potentiation was most pronounced after the first nitroglycerin infusion (12% versus 4.5% compared with placebo). A prolonged dilation of the temporal artery was observed only after the first nitroglycerin infusion, when high levels of N-acetylcysteine were present.

KW - Acetylcysteine

KW - Adult

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Drug Administration Schedule

KW - Drug Synergism

KW - Female

KW - Forearm

KW - Headache

KW - Hemodynamics

KW - Humans

KW - Male

KW - Nitroglycerin

KW - Skull

KW - Temporal Arteries

KW - Time Factors

KW - Vasodilation

M3 - Journal article

C2 - 1505148

VL - 52

SP - 125

EP - 133

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 2

ER -

ID: 128984638