Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

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Myeloperoxidase-derived oxidation : mechanisms of biological damage and its prevention. / Davies, Michael Jonathan.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 48, No. 1, 01.2011, p. 8-19.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Davies, MJ 2011, 'Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention', Journal of Clinical Biochemistry and Nutrition, vol. 48, no. 1, pp. 8-19. https://doi.org/10.3164/jcbn.11-006FR

APA

Davies, M. J. (2011). Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. Journal of Clinical Biochemistry and Nutrition, 48(1), 8-19. https://doi.org/10.3164/jcbn.11-006FR

Vancouver

Davies MJ. Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention. Journal of Clinical Biochemistry and Nutrition. 2011 Jan;48(1):8-19. https://doi.org/10.3164/jcbn.11-006FR

Author

Davies, Michael Jonathan. / Myeloperoxidase-derived oxidation : mechanisms of biological damage and its prevention. In: Journal of Clinical Biochemistry and Nutrition. 2011 ; Vol. 48, No. 1. pp. 8-19.

Bibtex

@article{1d54f3148d214f8a8823abff9f34e689,
title = "Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention",
abstract = "There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.",
author = "Davies, {Michael Jonathan}",
year = "2011",
month = "1",
doi = "10.3164/jcbn.11-006FR",
language = "English",
volume = "48",
pages = "8--19",
journal = "Journal of Clinical Biochemistry and Nutrition",
issn = "0912-0009",
publisher = "Institute of Applied Biochemistry",
number = "1",

}

RIS

TY - JOUR

T1 - Myeloperoxidase-derived oxidation

T2 - mechanisms of biological damage and its prevention

AU - Davies, Michael Jonathan

PY - 2011/1

Y1 - 2011/1

N2 - There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.

AB - There is considerable interest in the role that mammalian heme peroxidase enzymes, primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide range of human pathologies. This has been sparked by rapid developments in our understanding of the basic biochemistry of these enzymes, a greater understanding of the basic chemistry and biochemistry of the oxidants formed by these species, the development of biomarkers that can be used damage induced by these oxidants in vivo, and the recent identification of a number of compounds that show promise as inhibitors of these enzymes. Such compounds offer the possibility of modulating damage in a number of human pathologies. This reviews recent developments in our understanding of the biochemistry of myeloperoxidase, the oxidants that this enzyme generates, and the use of inhibitors to inhibit such damage.

U2 - 10.3164/jcbn.11-006FR

DO - 10.3164/jcbn.11-006FR

M3 - Journal article

C2 - 21297906

VL - 48

SP - 8

EP - 19

JO - Journal of Clinical Biochemistry and Nutrition

JF - Journal of Clinical Biochemistry and Nutrition

SN - 0912-0009

IS - 1

ER -

ID: 129669875