Multispectral UV Imaging for Determination of the Tablet Coating Thickness

Research output: Contribution to journalJournal articlepeer-review

Standard

Multispectral UV Imaging for Determination of the Tablet Coating Thickness. / Novikova, Anna; Carstensen, Jens M; Zeitler, J Axel; Rades, Thomas; Leopold, Claudia S.

In: Journal of Pharmaceutical Sciences, Vol. 106, No. 6, 06.2017, p. 1560-1569.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Novikova, A, Carstensen, JM, Zeitler, JA, Rades, T & Leopold, CS 2017, 'Multispectral UV Imaging for Determination of the Tablet Coating Thickness', Journal of Pharmaceutical Sciences, vol. 106, no. 6, pp. 1560-1569. https://doi.org/10.1016/j.xphs.2017.02.016

APA

Novikova, A., Carstensen, J. M., Zeitler, J. A., Rades, T., & Leopold, C. S. (2017). Multispectral UV Imaging for Determination of the Tablet Coating Thickness. Journal of Pharmaceutical Sciences, 106(6), 1560-1569. https://doi.org/10.1016/j.xphs.2017.02.016

Vancouver

Novikova A, Carstensen JM, Zeitler JA, Rades T, Leopold CS. Multispectral UV Imaging for Determination of the Tablet Coating Thickness. Journal of Pharmaceutical Sciences. 2017 Jun;106(6):1560-1569. https://doi.org/10.1016/j.xphs.2017.02.016

Author

Novikova, Anna ; Carstensen, Jens M ; Zeitler, J Axel ; Rades, Thomas ; Leopold, Claudia S. / Multispectral UV Imaging for Determination of the Tablet Coating Thickness. In: Journal of Pharmaceutical Sciences. 2017 ; Vol. 106, No. 6. pp. 1560-1569.

Bibtex

@article{8d141397e21648c595c513761e800379,
title = "Multispectral UV Imaging for Determination of the Tablet Coating Thickness",
abstract = "The applicability of off-line multispectral UV imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab-scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, 2 of which contained UV-active tablet cores. Three coating formulations were applied: Aquacoat{\textregistered} ECD (a mainly translucent coating) and Eudragit{\textregistered} NE (a turbid coating containing solid particles). It was shown that UV imaging is a fast and nondestructive method to predict individual tablet weight gain as well as coating thickness. The coating thickness distribution profiles determined by UV imaging correlated to the results of the TPI measurements. UV imaging appears to hold a significant potential as a process analytical technology tool for determination of the tablet coating thickness and its distribution resulting from its high measurement speed, high molar absorptivity, and a high scattering coefficient, in addition to relatively low costs.",
keywords = "Journal Article",
author = "Anna Novikova and Carstensen, {Jens M} and Zeitler, {J Axel} and Thomas Rades and Leopold, {Claudia S}",
note = "Copyright {\textcopyright} 2017 American Pharmacists Association{\textregistered}. Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = jun,
doi = "10.1016/j.xphs.2017.02.016",
language = "English",
volume = "106",
pages = "1560--1569",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Multispectral UV Imaging for Determination of the Tablet Coating Thickness

AU - Novikova, Anna

AU - Carstensen, Jens M

AU - Zeitler, J Axel

AU - Rades, Thomas

AU - Leopold, Claudia S

N1 - Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

PY - 2017/6

Y1 - 2017/6

N2 - The applicability of off-line multispectral UV imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab-scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, 2 of which contained UV-active tablet cores. Three coating formulations were applied: Aquacoat® ECD (a mainly translucent coating) and Eudragit® NE (a turbid coating containing solid particles). It was shown that UV imaging is a fast and nondestructive method to predict individual tablet weight gain as well as coating thickness. The coating thickness distribution profiles determined by UV imaging correlated to the results of the TPI measurements. UV imaging appears to hold a significant potential as a process analytical technology tool for determination of the tablet coating thickness and its distribution resulting from its high measurement speed, high molar absorptivity, and a high scattering coefficient, in addition to relatively low costs.

AB - The applicability of off-line multispectral UV imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab-scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, 2 of which contained UV-active tablet cores. Three coating formulations were applied: Aquacoat® ECD (a mainly translucent coating) and Eudragit® NE (a turbid coating containing solid particles). It was shown that UV imaging is a fast and nondestructive method to predict individual tablet weight gain as well as coating thickness. The coating thickness distribution profiles determined by UV imaging correlated to the results of the TPI measurements. UV imaging appears to hold a significant potential as a process analytical technology tool for determination of the tablet coating thickness and its distribution resulting from its high measurement speed, high molar absorptivity, and a high scattering coefficient, in addition to relatively low costs.

KW - Journal Article

U2 - 10.1016/j.xphs.2017.02.016

DO - 10.1016/j.xphs.2017.02.016

M3 - Journal article

C2 - 28259766

VL - 106

SP - 1560

EP - 1569

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 6

ER -

ID: 185720939