Multispectral UV Imaging for Determination of the Tablet Coating Thickness
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Multispectral UV Imaging for Determination of the Tablet Coating Thickness. / Novikova, Anna; Carstensen, Jens M; Zeitler, J Axel; Rades, Thomas; Leopold, Claudia S.
In: Journal of Pharmaceutical Sciences, Vol. 106, No. 6, 06.2017, p. 1560-1569.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Multispectral UV Imaging for Determination of the Tablet Coating Thickness
AU - Novikova, Anna
AU - Carstensen, Jens M
AU - Zeitler, J Axel
AU - Rades, Thomas
AU - Leopold, Claudia S
N1 - Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.
PY - 2017/6
Y1 - 2017/6
N2 - The applicability of off-line multispectral UV imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab-scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, 2 of which contained UV-active tablet cores. Three coating formulations were applied: Aquacoat® ECD (a mainly translucent coating) and Eudragit® NE (a turbid coating containing solid particles). It was shown that UV imaging is a fast and nondestructive method to predict individual tablet weight gain as well as coating thickness. The coating thickness distribution profiles determined by UV imaging correlated to the results of the TPI measurements. UV imaging appears to hold a significant potential as a process analytical technology tool for determination of the tablet coating thickness and its distribution resulting from its high measurement speed, high molar absorptivity, and a high scattering coefficient, in addition to relatively low costs.
AB - The applicability of off-line multispectral UV imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab-scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, 2 of which contained UV-active tablet cores. Three coating formulations were applied: Aquacoat® ECD (a mainly translucent coating) and Eudragit® NE (a turbid coating containing solid particles). It was shown that UV imaging is a fast and nondestructive method to predict individual tablet weight gain as well as coating thickness. The coating thickness distribution profiles determined by UV imaging correlated to the results of the TPI measurements. UV imaging appears to hold a significant potential as a process analytical technology tool for determination of the tablet coating thickness and its distribution resulting from its high measurement speed, high molar absorptivity, and a high scattering coefficient, in addition to relatively low costs.
KW - Journal Article
U2 - 10.1016/j.xphs.2017.02.016
DO - 10.1016/j.xphs.2017.02.016
M3 - Journal article
C2 - 28259766
VL - 106
SP - 1560
EP - 1569
JO - Journal of Pharmaceutical Sciences
JF - Journal of Pharmaceutical Sciences
SN - 0022-3549
IS - 6
ER -
ID: 185720939