Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms

Research output: Contribution to journalJournal articlepeer-review

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Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms. / Kesselheim, Janine; Takemi, Mitsuaki; Christiansen, Lasse; Karabanov, Anke Ninija; Siebner, Hartwig Roman.

In: Journal of Neurophysiology, Vol. 129, No. 2, 2023, p. 410-420.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Kesselheim, J, Takemi, M, Christiansen, L, Karabanov, AN & Siebner, HR 2023, 'Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms', Journal of Neurophysiology, vol. 129, no. 2, pp. 410-420. https://doi.org/10.1152/jn.00263.2022

APA

Kesselheim, J., Takemi, M., Christiansen, L., Karabanov, A. N., & Siebner, H. R. (2023). Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms. Journal of Neurophysiology, 129(2), 410-420. https://doi.org/10.1152/jn.00263.2022

Vancouver

Kesselheim J, Takemi M, Christiansen L, Karabanov AN, Siebner HR. Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms. Journal of Neurophysiology. 2023;129(2):410-420. https://doi.org/10.1152/jn.00263.2022

Author

Kesselheim, Janine ; Takemi, Mitsuaki ; Christiansen, Lasse ; Karabanov, Anke Ninija ; Siebner, Hartwig Roman. / Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms. In: Journal of Neurophysiology. 2023 ; Vol. 129, No. 2. pp. 410-420.

Bibtex

@article{b5cff178319b4f598d7fd47b15c5e0ea,
title = "Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms",
abstract = "Single-pulse transcranial magnetic stimulation (TMS) of the precentral hand representation (M1HAND) can elicit indirect waves in the corticospinal tract at a periodicity of ∼660 Hz, called I-waves. These descending volleys are produced by transsynaptic excitation of fast-conducting corticospinal axons in M1HAND. Paired-pulse TMS can induce short-interval intracortical facilitation (SICF) of motor evoked potentials (MEPs) at interpulse intervals that match I-wave periodicity. This study examined whether short-latency corticospinal facilitation engages additional mechanisms independently of I-wave periodicity. In 19 volunteers, one to four biphasic TMS pulses were applied to left M1HAND with interpulse intervals adjusted to the first peak or trough of the individual SICF curve at different intensities to probe the intensity-response relationship. Multipulse TMSHAND at individual peak latency facilitated MEP amplitudes and reduced resting motor threshold (RMT) compared with single pulses. Multipulse TMSHAND at individual trough latency also produced a consistent facilitation of MEPs and a reduction of RMT. Short-latency facilitation at trough latency was less pronounced, but the relative difference in facilitation decreased with increasing stimulus intensity. Increasing the pulse number had only a modest effect. Two mechanisms underlie short-latency facilitation caused by biphasic multipulse TMSHAND. One intracortical mechanism is related to I-wave periodicity and engages fast-conducting direct projections to spinal motoneurons. A second corticospinal mechanism does not rely on I-wave rhythmicity and may be mediated by slower-conducting indirect pyramidal tract projections from M1HAND to spinal interneurons. The latter mechanism deserves more attention in studies of the corticomotor system and its link to manual motor control using the MEP.",
keywords = "Faculty of Science, Transcranial magnetic stimulation, Motor cortex, Short latency intracortical facilitation, I-waves",
author = "Janine Kesselheim and Mitsuaki Takemi and Lasse Christiansen and Karabanov, {Anke Ninija} and Siebner, {Hartwig Roman}",
note = "CURIS 2023 NEXS 046",
year = "2023",
doi = "10.1152/jn.00263.2022",
language = "English",
volume = "129",
pages = "410--420",
journal = "Journal of Neurophysiology",
issn = "0022-3077",
publisher = "American Physiological Society",
number = "2",

}

RIS

TY - JOUR

T1 - Multipulse transcranial magnetic stimulation of human motor cortex produces short-latency corticomotor facilitation via two distinct mechanisms

AU - Kesselheim, Janine

AU - Takemi, Mitsuaki

AU - Christiansen, Lasse

AU - Karabanov, Anke Ninija

AU - Siebner, Hartwig Roman

N1 - CURIS 2023 NEXS 046

PY - 2023

Y1 - 2023

N2 - Single-pulse transcranial magnetic stimulation (TMS) of the precentral hand representation (M1HAND) can elicit indirect waves in the corticospinal tract at a periodicity of ∼660 Hz, called I-waves. These descending volleys are produced by transsynaptic excitation of fast-conducting corticospinal axons in M1HAND. Paired-pulse TMS can induce short-interval intracortical facilitation (SICF) of motor evoked potentials (MEPs) at interpulse intervals that match I-wave periodicity. This study examined whether short-latency corticospinal facilitation engages additional mechanisms independently of I-wave periodicity. In 19 volunteers, one to four biphasic TMS pulses were applied to left M1HAND with interpulse intervals adjusted to the first peak or trough of the individual SICF curve at different intensities to probe the intensity-response relationship. Multipulse TMSHAND at individual peak latency facilitated MEP amplitudes and reduced resting motor threshold (RMT) compared with single pulses. Multipulse TMSHAND at individual trough latency also produced a consistent facilitation of MEPs and a reduction of RMT. Short-latency facilitation at trough latency was less pronounced, but the relative difference in facilitation decreased with increasing stimulus intensity. Increasing the pulse number had only a modest effect. Two mechanisms underlie short-latency facilitation caused by biphasic multipulse TMSHAND. One intracortical mechanism is related to I-wave periodicity and engages fast-conducting direct projections to spinal motoneurons. A second corticospinal mechanism does not rely on I-wave rhythmicity and may be mediated by slower-conducting indirect pyramidal tract projections from M1HAND to spinal interneurons. The latter mechanism deserves more attention in studies of the corticomotor system and its link to manual motor control using the MEP.

AB - Single-pulse transcranial magnetic stimulation (TMS) of the precentral hand representation (M1HAND) can elicit indirect waves in the corticospinal tract at a periodicity of ∼660 Hz, called I-waves. These descending volleys are produced by transsynaptic excitation of fast-conducting corticospinal axons in M1HAND. Paired-pulse TMS can induce short-interval intracortical facilitation (SICF) of motor evoked potentials (MEPs) at interpulse intervals that match I-wave periodicity. This study examined whether short-latency corticospinal facilitation engages additional mechanisms independently of I-wave periodicity. In 19 volunteers, one to four biphasic TMS pulses were applied to left M1HAND with interpulse intervals adjusted to the first peak or trough of the individual SICF curve at different intensities to probe the intensity-response relationship. Multipulse TMSHAND at individual peak latency facilitated MEP amplitudes and reduced resting motor threshold (RMT) compared with single pulses. Multipulse TMSHAND at individual trough latency also produced a consistent facilitation of MEPs and a reduction of RMT. Short-latency facilitation at trough latency was less pronounced, but the relative difference in facilitation decreased with increasing stimulus intensity. Increasing the pulse number had only a modest effect. Two mechanisms underlie short-latency facilitation caused by biphasic multipulse TMSHAND. One intracortical mechanism is related to I-wave periodicity and engages fast-conducting direct projections to spinal motoneurons. A second corticospinal mechanism does not rely on I-wave rhythmicity and may be mediated by slower-conducting indirect pyramidal tract projections from M1HAND to spinal interneurons. The latter mechanism deserves more attention in studies of the corticomotor system and its link to manual motor control using the MEP.

KW - Faculty of Science

KW - Transcranial magnetic stimulation

KW - Motor cortex

KW - Short latency intracortical facilitation

KW - I-waves

U2 - 10.1152/jn.00263.2022

DO - 10.1152/jn.00263.2022

M3 - Journal article

C2 - 36629338

VL - 129

SP - 410

EP - 420

JO - Journal of Neurophysiology

JF - Journal of Neurophysiology

SN - 0022-3077

IS - 2

ER -

ID: 333034927