Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia
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Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia. / Kjær, Marie; Frederiksen, Amalie Kruse Sigersted; Nissen, Neel Ingemann; Willumsen, Nicholas; van Hall, Gerrit; Jørgensen, Lars Nannestad; Andersen, Jens Rikardt; Ågren, Magnus S.
In: Journal of Nutrition, Vol. 150, No. 4, 2020, p. 792-799.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Multinutrient supplementation increases collagen synthesis during early wound repair in a randomized controlled trial in patients with inguinal hernia
AU - Kjær, Marie
AU - Frederiksen, Amalie Kruse Sigersted
AU - Nissen, Neel Ingemann
AU - Willumsen, Nicholas
AU - van Hall, Gerrit
AU - Jørgensen, Lars Nannestad
AU - Andersen, Jens Rikardt
AU - Ågren, Magnus S
N1 - Copyright © The Author(s) 2020.
PY - 2020
Y1 - 2020
N2 - Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis.Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in inguinal hernia disease patients when undergoing hernia repair.Methods: In this exploratory randomized controlled trial, 21 men (age: 55.2 ± 2.8 y; BMI: 25.0 ± 0.7 kg/m2) scheduled for Lichtenstein inguinal hernia repair were assigned to multinutrient supplementation (n = 10; multinutrient group) or no multinutrient supplementation (n = 11; control group). The multinutrient group received 14 g l-arginine, 14 g l-glutamine, 1250 mg vitamin C, and 55 mg zinc daily starting 14 d before surgery and ending 14 d after surgery. The multinutrient and control groups received high-quality protein to ensure a daily intake of 1.5 g protein/kg. Collagen biosynthesis was measured by the biomarkers type I procollagen propeptide (CICP), type III procollagen propeptide (PRO-C3), and type V procollagen propeptide (PRO-C5) in the sera on days -14, 0, and 1, and in the wound fluids on postoperative days 1 and 2. Compliance was recorded after the 28-d intervention period.Results: Serum PRO-C5 concentrations decreased (P < 0.05) postoperatively in the control but not the multinutrient group. Neither CICP nor PRO-C3 serum concentrations differed significantly between the 2 groups. In wound fluid, the CICP concentrations increased (P < 0.05) from days 1 to 2 in the multinutrient group and were 49% higher (P = 0.10) than those in the control group on day 2. Wound fluid concentrations PRO-C3 and PRO-C5 showed no significant time or group differences. The 28-d compliance was similar (P = 0.27) in the 2 groups.Conclusion: Oral supplementation with arginine, glutamine, vitamin C, and zinc augment collagen synthesis during the first 2 d after inguinal hernia repair. This trial was registered at clinicaltrials.gov as NCT03221686.
AB - Background: Inguinal hernia disease is associated with an imbalanced collagen metabolism. Surgical stress has a negative impact on nutrients important for collagen synthesis.Objective: We hypothesized that supplementation with a combination of nutrients would enhance collagen biosynthesis in inguinal hernia disease patients when undergoing hernia repair.Methods: In this exploratory randomized controlled trial, 21 men (age: 55.2 ± 2.8 y; BMI: 25.0 ± 0.7 kg/m2) scheduled for Lichtenstein inguinal hernia repair were assigned to multinutrient supplementation (n = 10; multinutrient group) or no multinutrient supplementation (n = 11; control group). The multinutrient group received 14 g l-arginine, 14 g l-glutamine, 1250 mg vitamin C, and 55 mg zinc daily starting 14 d before surgery and ending 14 d after surgery. The multinutrient and control groups received high-quality protein to ensure a daily intake of 1.5 g protein/kg. Collagen biosynthesis was measured by the biomarkers type I procollagen propeptide (CICP), type III procollagen propeptide (PRO-C3), and type V procollagen propeptide (PRO-C5) in the sera on days -14, 0, and 1, and in the wound fluids on postoperative days 1 and 2. Compliance was recorded after the 28-d intervention period.Results: Serum PRO-C5 concentrations decreased (P < 0.05) postoperatively in the control but not the multinutrient group. Neither CICP nor PRO-C3 serum concentrations differed significantly between the 2 groups. In wound fluid, the CICP concentrations increased (P < 0.05) from days 1 to 2 in the multinutrient group and were 49% higher (P = 0.10) than those in the control group on day 2. Wound fluid concentrations PRO-C3 and PRO-C5 showed no significant time or group differences. The 28-d compliance was similar (P = 0.27) in the 2 groups.Conclusion: Oral supplementation with arginine, glutamine, vitamin C, and zinc augment collagen synthesis during the first 2 d after inguinal hernia repair. This trial was registered at clinicaltrials.gov as NCT03221686.
KW - Faculty of Science
KW - Collagen synthesis
KW - Wound healing
KW - Surgery
KW - Biomarkers
KW - Zink
KW - Ascorbic acid
KW - Amino acids
U2 - 10.1093/jn/nxz324
DO - 10.1093/jn/nxz324
M3 - Journal article
C2 - 31897483
VL - 150
SP - 792
EP - 799
JO - Journal of Nutrition
JF - Journal of Nutrition
SN - 0022-3166
IS - 4
ER -
ID: 237653335