Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

Research output: Contribution to journalJournal articleResearchpeer-review

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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. / Pinela da Silva, Sonia Cristina; Altmannova, Veronika; Luke-Glaser, Sarah; Henriksen, Peter; Gallina, Irene; Yang, Xuejiao; Choudhary, Chuna Ram; Luke, Brian; Krejci, Lumir; Lisby, Michael.

In: Genes & Development, Vol. 30, No. 6, 2016, p. 700-717.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Pinela da Silva, SC, Altmannova, V, Luke-Glaser, S, Henriksen, P, Gallina, I, Yang, X, Choudhary, CR, Luke, B, Krejci, L & Lisby, M 2016, 'Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance', Genes & Development, vol. 30, no. 6, pp. 700-717. https://doi.org/10.1101/gad.276204.115

APA

Pinela da Silva, S. C., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, I., Yang, X., ... Lisby, M. (2016). Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes & Development, 30(6), 700-717. https://doi.org/10.1101/gad.276204.115

Vancouver

Pinela da Silva SC, Altmannova V, Luke-Glaser S, Henriksen P, Gallina I, Yang X et al. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes & Development. 2016;30(6):700-717. https://doi.org/10.1101/gad.276204.115

Author

Pinela da Silva, Sonia Cristina ; Altmannova, Veronika ; Luke-Glaser, Sarah ; Henriksen, Peter ; Gallina, Irene ; Yang, Xuejiao ; Choudhary, Chuna Ram ; Luke, Brian ; Krejci, Lumir ; Lisby, Michael. / Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. In: Genes & Development. 2016 ; Vol. 30, No. 6. pp. 700-717.

Bibtex

@article{a3133f6e71384deb9b77023b440914b8,
title = "Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance",
abstract = "Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such a D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.",
author = "{Pinela da Silva}, {Sonia Cristina} and Veronika Altmannova and Sarah Luke-Glaser and Peter Henriksen and Irene Gallina and Xuejiao Yang and Choudhary, {Chuna Ram} and Brian Luke and Lumir Krejci and Michael Lisby",
note = "{\circledC} 2016 Silva et al.; Published by Cold Spring Harbor Laboratory Press.",
year = "2016",
doi = "10.1101/gad.276204.115",
language = "English",
volume = "30",
pages = "700--717",
journal = "Genes & Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "6",

}

RIS

TY - JOUR

T1 - Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

AU - Pinela da Silva, Sonia Cristina

AU - Altmannova, Veronika

AU - Luke-Glaser, Sarah

AU - Henriksen, Peter

AU - Gallina, Irene

AU - Yang, Xuejiao

AU - Choudhary, Chuna Ram

AU - Luke, Brian

AU - Krejci, Lumir

AU - Lisby, Michael

N1 - © 2016 Silva et al.; Published by Cold Spring Harbor Laboratory Press.

PY - 2016

Y1 - 2016

N2 - Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such a D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.

AB - Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae. In vitro, Mte1 (Mph1-associated telomere maintenance protein 1) binds directly to DNA with a preference for branched molecules such a D loops and fork structures. In addition, Mte1 stimulates the helicase and fork regression activities of Mph1 while inhibiting the ability of Mph1 to dissociate recombination intermediates. Deletion of MTE1 reduces crossover recombination and suppresses the sensitivity of mph1Δ mutant cells to replication stress. Mph1 and Mte1 interdependently colocalize at DNA damage-induced foci and dysfunctional telomeres, and MTE1 deletion results in elongated telomeres. Taken together, our data indicate that Mte1 plays a role in regulation of crossover recombination, response to replication stress, and telomere maintenance.

U2 - 10.1101/gad.276204.115

DO - 10.1101/gad.276204.115

M3 - Journal article

C2 - 26966248

VL - 30

SP - 700

EP - 717

JO - Genes & Development

JF - Genes & Development

SN - 0890-9369

IS - 6

ER -

ID: 157550198