MitophAging: Mitophagy in Aging and Disease

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MitophAging : Mitophagy in Aging and Disease. / Bakula, Daniela; Scheibye-Knudsen, Morten.

In: Frontiers in Cell and Developmental Biology, Vol. 8, 239, 2020.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Bakula, D & Scheibye-Knudsen, M 2020, 'MitophAging: Mitophagy in Aging and Disease', Frontiers in Cell and Developmental Biology, vol. 8, 239. https://doi.org/10.3389/fcell.2020.00239

APA

Bakula, D., & Scheibye-Knudsen, M. (2020). MitophAging: Mitophagy in Aging and Disease. Frontiers in Cell and Developmental Biology, 8, [239]. https://doi.org/10.3389/fcell.2020.00239

Vancouver

Bakula D, Scheibye-Knudsen M. MitophAging: Mitophagy in Aging and Disease. Frontiers in Cell and Developmental Biology. 2020;8. 239. https://doi.org/10.3389/fcell.2020.00239

Author

Bakula, Daniela ; Scheibye-Knudsen, Morten. / MitophAging : Mitophagy in Aging and Disease. In: Frontiers in Cell and Developmental Biology. 2020 ; Vol. 8.

Bibtex

@article{2bda14c76c2147b791218d0504ce76da,
title = "MitophAging: Mitophagy in Aging and Disease",
abstract = "Maintaining mitochondrial health is emerging as a keystone in aging and associated diseases. The selective degradation of mitochondria by mitophagy is of particular importance in keeping a pristine mitochondrial pool. Indeed, inherited monogenic diseases with defects in mitophagy display complex multisystem pathologies but particularly progressive neurodegeneration. Fortunately, therapies are being developed that target mitophagy allowing new hope for treatments for previously incurable diseases. Herein, we describe mitophagy and associated diseases, coin the term mitophaging and describe new small molecule interventions that target different steps in the mitophagic pathway. Consequently, several age-associated diseases may be treated by targeting mitophagy.",
keywords = "aging, autophagy, interventions, mitophaging, mitophagy, monogenic disorders",
author = "Daniela Bakula and Morten Scheibye-Knudsen",
year = "2020",
doi = "10.3389/fcell.2020.00239",
language = "English",
volume = "8",
journal = "Frontiers in Cell and Developmental Biology",
issn = "2296-634X",
publisher = "Frontiers Media",

}

RIS

TY - JOUR

T1 - MitophAging

T2 - Mitophagy in Aging and Disease

AU - Bakula, Daniela

AU - Scheibye-Knudsen, Morten

PY - 2020

Y1 - 2020

N2 - Maintaining mitochondrial health is emerging as a keystone in aging and associated diseases. The selective degradation of mitochondria by mitophagy is of particular importance in keeping a pristine mitochondrial pool. Indeed, inherited monogenic diseases with defects in mitophagy display complex multisystem pathologies but particularly progressive neurodegeneration. Fortunately, therapies are being developed that target mitophagy allowing new hope for treatments for previously incurable diseases. Herein, we describe mitophagy and associated diseases, coin the term mitophaging and describe new small molecule interventions that target different steps in the mitophagic pathway. Consequently, several age-associated diseases may be treated by targeting mitophagy.

AB - Maintaining mitochondrial health is emerging as a keystone in aging and associated diseases. The selective degradation of mitochondria by mitophagy is of particular importance in keeping a pristine mitochondrial pool. Indeed, inherited monogenic diseases with defects in mitophagy display complex multisystem pathologies but particularly progressive neurodegeneration. Fortunately, therapies are being developed that target mitophagy allowing new hope for treatments for previously incurable diseases. Herein, we describe mitophagy and associated diseases, coin the term mitophaging and describe new small molecule interventions that target different steps in the mitophagic pathway. Consequently, several age-associated diseases may be treated by targeting mitophagy.

KW - aging

KW - autophagy

KW - interventions

KW - mitophaging

KW - mitophagy

KW - monogenic disorders

U2 - 10.3389/fcell.2020.00239

DO - 10.3389/fcell.2020.00239

M3 - Review

C2 - 32373609

AN - SCOPUS:85083970977

VL - 8

JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

SN - 2296-634X

M1 - 239

ER -

ID: 242781853