Mitochondrial helicases and mitochondrial genome maintenance
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Mitochondrial helicases and mitochondrial genome maintenance. / de Souza-Pinto, Nadja C; Aamann, Maria Diget; Kulikowicz, Tomasz; Stevnsner, Tinna V.; Bohr, Vilhelm A.
In: Mechanisms of Ageing and Development, Vol. 131, No. 7-8, 2010, p. 503-10.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mitochondrial helicases and mitochondrial genome maintenance
AU - de Souza-Pinto, Nadja C
AU - Aamann, Maria Diget
AU - Kulikowicz, Tomasz
AU - Stevnsner, Tinna V.
AU - Bohr, Vilhelm A
N1 - Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
PY - 2010
Y1 - 2010
N2 - Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.
AB - Helicases are essential enzymes that utilize the energy of nucleotide hydrolysis to drive unwinding of nucleic acid duplexes. Helicases play roles in all aspects of DNA metabolism including DNA repair, DNA replication and transcription. The subcellular locations and functions of several helicases have been studied in detail; however, the roles of specific helicases in mitochondrial biology remain poorly characterized. This review presents important recent advances in identifying and characterizing mitochondrial helicases, some of which also operate in the nucleus.
KW - Age Factors
KW - Aging
KW - Animals
KW - DNA Helicases
KW - DNA, Mitochondrial
KW - Gene Expression Regulation
KW - Humans
KW - Mitochondria
U2 - 10.1016/j.mad.2010.04.009
DO - 10.1016/j.mad.2010.04.009
M3 - Journal article
C2 - 20576512
VL - 131
SP - 503
EP - 510
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 7-8
ER -
ID: 33492166