Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Mid- to late-life migraine diagnoses and risk of dementia : a national register-based follow-up study. / Islamoska, Sabrina; Hansen, Åse Marie; Wang, Hui-Xin; Garde, Anne Helene; Andersen, Per Kragh; Garde, Ellen; Hansen, Jakob Møller; Waldemar, Gunhild; Nabe-Nielsen, Kirsten.

In: The Journal of Headache and Pain, Vol. 21, 98, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Islamoska, S, Hansen, ÅM, Wang, H-X, Garde, AH, Andersen, PK, Garde, E, Hansen, JM, Waldemar, G & Nabe-Nielsen, K 2020, 'Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study', The Journal of Headache and Pain, vol. 21, 98. https://doi.org/10.1186/s10194-020-01166-7

APA

Islamoska, S., Hansen, Å. M., Wang, H-X., Garde, A. H., Andersen, P. K., Garde, E., ... Nabe-Nielsen, K. (2020). Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study. The Journal of Headache and Pain, 21, [98]. https://doi.org/10.1186/s10194-020-01166-7

Vancouver

Islamoska S, Hansen ÅM, Wang H-X, Garde AH, Andersen PK, Garde E et al. Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study. The Journal of Headache and Pain. 2020;21. 98. https://doi.org/10.1186/s10194-020-01166-7

Author

Islamoska, Sabrina ; Hansen, Åse Marie ; Wang, Hui-Xin ; Garde, Anne Helene ; Andersen, Per Kragh ; Garde, Ellen ; Hansen, Jakob Møller ; Waldemar, Gunhild ; Nabe-Nielsen, Kirsten. / Mid- to late-life migraine diagnoses and risk of dementia : a national register-based follow-up study. In: The Journal of Headache and Pain. 2020 ; Vol. 21.

Bibtex

@article{78142d1deeec440a9406d40779be5c77,
title = "Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study",
abstract = "Background: Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all prevalent dementia subtypes. The main objective of this national register-based study was to investigate whether migraine was a risk factor for dementia. Additionally, we explored potential differences in dementia risk for migraine with and without aura.Methods: We obtained data on birth cohorts born between 1935 and 1956 (n = 1,657,890) from Danish national registers. Individuals registered with migraine before age 59 (n = 18,135) were matched (1:5) on sex and birthdate with individuals without migraine (n = 1,378,346). Migraine was defined by International Classification of Diseases (ICD) diagnoses and dementia was defined by ICD diagnoses and anti-dementia medication. After matching, 62,578 individuals were eligible for analysis. For the statistical analyses, we used Cox regression models and adjusted for socio-demographic factors and several psychiatric and somatic morbidities.Results: During a median follow-up time of 6.9 (IQR: 3.6–11.2) years, 207 individuals with migraine developed dementia. Compared with individuals without migraine, we found a 50{\%} higher rate of dementia among individuals with migraine (HR = 1.50; 95{\%} CI: 1.28–1.76). Individuals without aura had a 19{\%} higher rate of dementia (HR = 1.19; 95{\%} CI: 0.84–1.70), and individuals with aura had a two times higher rate of dementia (HR = 2.11; 95{\%} CI: 1.48–3.00).Conclusions: Our findings support the hypothesis that migraine is a midlife risk factor for dementia in later life. The higher rate of dementia in individuals with a hospital-based diagnosis of migraine with aura emphasizes the need for studies on pathological mechanisms and potential preventative measures. Furthermore, given that only hospital-based migraine diagnoses were included in this study, future research should also investigate migraine cases derived from the primary healthcare system to include less severe migraine cases.",
author = "Sabrina Islamoska and Hansen, {{\AA}se Marie} and Hui-Xin Wang and Garde, {Anne Helene} and Andersen, {Per Kragh} and Ellen Garde and Hansen, {Jakob M{\o}ller} and Gunhild Waldemar and Kirsten Nabe-Nielsen",
year = "2020",
doi = "10.1186/s10194-020-01166-7",
language = "English",
volume = "21",
journal = "Journal of Headache and Pain",
issn = "1129-2369",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Mid- to late-life migraine diagnoses and risk of dementia

T2 - a national register-based follow-up study

AU - Islamoska, Sabrina

AU - Hansen, Åse Marie

AU - Wang, Hui-Xin

AU - Garde, Anne Helene

AU - Andersen, Per Kragh

AU - Garde, Ellen

AU - Hansen, Jakob Møller

AU - Waldemar, Gunhild

AU - Nabe-Nielsen, Kirsten

PY - 2020

Y1 - 2020

N2 - Background: Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all prevalent dementia subtypes. The main objective of this national register-based study was to investigate whether migraine was a risk factor for dementia. Additionally, we explored potential differences in dementia risk for migraine with and without aura.Methods: We obtained data on birth cohorts born between 1935 and 1956 (n = 1,657,890) from Danish national registers. Individuals registered with migraine before age 59 (n = 18,135) were matched (1:5) on sex and birthdate with individuals without migraine (n = 1,378,346). Migraine was defined by International Classification of Diseases (ICD) diagnoses and dementia was defined by ICD diagnoses and anti-dementia medication. After matching, 62,578 individuals were eligible for analysis. For the statistical analyses, we used Cox regression models and adjusted for socio-demographic factors and several psychiatric and somatic morbidities.Results: During a median follow-up time of 6.9 (IQR: 3.6–11.2) years, 207 individuals with migraine developed dementia. Compared with individuals without migraine, we found a 50% higher rate of dementia among individuals with migraine (HR = 1.50; 95% CI: 1.28–1.76). Individuals without aura had a 19% higher rate of dementia (HR = 1.19; 95% CI: 0.84–1.70), and individuals with aura had a two times higher rate of dementia (HR = 2.11; 95% CI: 1.48–3.00).Conclusions: Our findings support the hypothesis that migraine is a midlife risk factor for dementia in later life. The higher rate of dementia in individuals with a hospital-based diagnosis of migraine with aura emphasizes the need for studies on pathological mechanisms and potential preventative measures. Furthermore, given that only hospital-based migraine diagnoses were included in this study, future research should also investigate migraine cases derived from the primary healthcare system to include less severe migraine cases.

AB - Background: Previous studies found an association between migraine and dementia, which are two leading causes of disability. However, these studies did not differentiate between migraine types and did not investigate all prevalent dementia subtypes. The main objective of this national register-based study was to investigate whether migraine was a risk factor for dementia. Additionally, we explored potential differences in dementia risk for migraine with and without aura.Methods: We obtained data on birth cohorts born between 1935 and 1956 (n = 1,657,890) from Danish national registers. Individuals registered with migraine before age 59 (n = 18,135) were matched (1:5) on sex and birthdate with individuals without migraine (n = 1,378,346). Migraine was defined by International Classification of Diseases (ICD) diagnoses and dementia was defined by ICD diagnoses and anti-dementia medication. After matching, 62,578 individuals were eligible for analysis. For the statistical analyses, we used Cox regression models and adjusted for socio-demographic factors and several psychiatric and somatic morbidities.Results: During a median follow-up time of 6.9 (IQR: 3.6–11.2) years, 207 individuals with migraine developed dementia. Compared with individuals without migraine, we found a 50% higher rate of dementia among individuals with migraine (HR = 1.50; 95% CI: 1.28–1.76). Individuals without aura had a 19% higher rate of dementia (HR = 1.19; 95% CI: 0.84–1.70), and individuals with aura had a two times higher rate of dementia (HR = 2.11; 95% CI: 1.48–3.00).Conclusions: Our findings support the hypothesis that migraine is a midlife risk factor for dementia in later life. The higher rate of dementia in individuals with a hospital-based diagnosis of migraine with aura emphasizes the need for studies on pathological mechanisms and potential preventative measures. Furthermore, given that only hospital-based migraine diagnoses were included in this study, future research should also investigate migraine cases derived from the primary healthcare system to include less severe migraine cases.

U2 - 10.1186/s10194-020-01166-7

DO - 10.1186/s10194-020-01166-7

M3 - Journal article

C2 - 32762715

VL - 21

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

SN - 1129-2369

M1 - 98

ER -

ID: 246671289