MicroRNAs, epigenetics and disease

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MicroRNAs, epigenetics and disease. / Silahtaroglu, Asli; Stenvang, Jan.

In: Essays in Biochemistry, Vol. 48, No. 1, 2010, p. 165-185.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Silahtaroglu, A & Stenvang, J 2010, 'MicroRNAs, epigenetics and disease', Essays in Biochemistry, vol. 48, no. 1, pp. 165-185. https://doi.org/10.1042/bse0480165

APA

Silahtaroglu, A., & Stenvang, J. (2010). MicroRNAs, epigenetics and disease. Essays in Biochemistry, 48(1), 165-185. https://doi.org/10.1042/bse0480165

Vancouver

Silahtaroglu A, Stenvang J. MicroRNAs, epigenetics and disease. Essays in Biochemistry. 2010;48(1):165-185. https://doi.org/10.1042/bse0480165

Author

Silahtaroglu, Asli ; Stenvang, Jan. / MicroRNAs, epigenetics and disease. In: Essays in Biochemistry. 2010 ; Vol. 48, No. 1. pp. 165-185.

Bibtex

@article{d82aefbfcd8347a3954ff1159ef27b87,
title = "MicroRNAs, epigenetics and disease",
abstract = "Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation, development and maintenance of tissue-specific gene expression. These mechanisms also explain how cells with the same DNA content can differentiate into cells with different functions. Changes in epigenetic processes can lead to changes in gene function, cancer formation and progression, as well as other diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer.",
keywords = "Disease, Epigenesis, Genetic, Humans, MicroRNAs",
author = "Asli Silahtaroglu and Jan Stenvang",
year = "2010",
doi = "10.1042/bse0480165",
language = "English",
volume = "48",
pages = "165--185",
journal = "Essays in Biochemistry",
issn = "0071-1365",
publisher = "Portland Press Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - MicroRNAs, epigenetics and disease

AU - Silahtaroglu, Asli

AU - Stenvang, Jan

PY - 2010

Y1 - 2010

N2 - Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation, development and maintenance of tissue-specific gene expression. These mechanisms also explain how cells with the same DNA content can differentiate into cells with different functions. Changes in epigenetic processes can lead to changes in gene function, cancer formation and progression, as well as other diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer.

AB - Epigenetics is defined as the heritable chances that affect gene expression without changing the DNA sequence. Epigenetic regulation of gene expression can be through different mechanisms such as DNA methylation, histone modifications and nucleosome positioning. MicroRNAs are short RNA molecules which do not code for a protein but have a role in post-transcriptional silencing of multiple target genes by binding to their 3' UTRs (untranslated regions). Both epigenetic mechanisms, such as DNA methylation and histone modifications, and the microRNAs are crucial for normal differentiation, development and maintenance of tissue-specific gene expression. These mechanisms also explain how cells with the same DNA content can differentiate into cells with different functions. Changes in epigenetic processes can lead to changes in gene function, cancer formation and progression, as well as other diseases. In the present chapter we will mainly focus on microRNAs and methylation and their implications in human disease, mainly in cancer.

KW - Disease

KW - Epigenesis, Genetic

KW - Humans

KW - MicroRNAs

U2 - 10.1042/bse0480165

DO - 10.1042/bse0480165

M3 - Journal article

C2 - 20822493

VL - 48

SP - 165

EP - 185

JO - Essays in Biochemistry

JF - Essays in Biochemistry

SN - 0071-1365

IS - 1

ER -

ID: 32137033