Methodological aspects of health-related quality of life measurement and analysis in patients with multiple myeloma
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Methodological aspects of health-related quality of life measurement and analysis in patients with multiple myeloma. / Nielsen, Lene Kongsgaard; Abildgaard, Niels; Jarden, Mary; Klausen, Tobias Wirenfeld.
In: British Journal of Haematology, Vol. 185, No. 1, 2019, p. 11-24.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Methodological aspects of health-related quality of life measurement and analysis in patients with multiple myeloma
AU - Nielsen, Lene Kongsgaard
AU - Abildgaard, Niels
AU - Jarden, Mary
AU - Klausen, Tobias Wirenfeld
PY - 2019
Y1 - 2019
N2 - Multiple myeloma (MM) is an incurable but treatment-sensitive cancer. For most patients, this means treatment with multiple lines of anti-myeloma therapy and a life with disease- and treatment-related symptoms and complications. Health-related quality of life (HRQoL) issues play an important role in treatment decision-making. Methodological challenges in longitudinal HRQoL measurements and analyses have been identified, including non-responses (NR) to scheduled questionnaires. Publications were identified for inclusion in a systematic review of longitudinal HRQoL studies in MM, focussing on methodological aspects of HRQoL measurement and analysis. Diversity in timing of HRQoL data collection and applied statistical methods were noted. We observed a high rate of NR, but the impact of NR was investigated in only 8/23 studies. Thus, evidence-based knowledge of HRQoL in patients with MM is compromised. To improve quality of HRQoL results and their implementation in daily practice, future studies should follow established guidelines.
AB - Multiple myeloma (MM) is an incurable but treatment-sensitive cancer. For most patients, this means treatment with multiple lines of anti-myeloma therapy and a life with disease- and treatment-related symptoms and complications. Health-related quality of life (HRQoL) issues play an important role in treatment decision-making. Methodological challenges in longitudinal HRQoL measurements and analyses have been identified, including non-responses (NR) to scheduled questionnaires. Publications were identified for inclusion in a systematic review of longitudinal HRQoL studies in MM, focussing on methodological aspects of HRQoL measurement and analysis. Diversity in timing of HRQoL data collection and applied statistical methods were noted. We observed a high rate of NR, but the impact of NR was investigated in only 8/23 studies. Thus, evidence-based knowledge of HRQoL in patients with MM is compromised. To improve quality of HRQoL results and their implementation in daily practice, future studies should follow established guidelines.
KW - health-related quality of life
KW - missing data
KW - multiple myeloma
KW - review
KW - statistical analysis
U2 - 10.1111/bjh.15759
DO - 10.1111/bjh.15759
M3 - Review
C2 - 30656677
AN - SCOPUS:85060210120
VL - 185
SP - 11
EP - 24
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -
ID: 241430828