This chapter is based on discussions at a workshop at the Nordic Social Pharmacy Conference in 2019, named How do we know it’s good? A workshop on quality criteria in qualitative social and clinical pharmacy research. After an introduction, the chapter continues with a glance at two different epistemologies. Thereafter, reflections on the challenges that many social pharmacy researchers meet as they come from a natural science background into qualitative research are presented. Specific aspects presented and discussed are: methodological and disciplinary competence and insecurity, reflexivity, transparency, checklists, quality criteria, sample size, and saturation.