Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults. / Demant, Mia; Suppli, Malte Palm; Foghsgaard, Signe; Gether, Lise; Grøndahl, Magnus Frederik Gluud; Dalsgaard, Niels Bjørn; Bergmann, Sigrid S; Lanng, Amalie Rasmussen; Gasbjerg, Lærke S; Thomasen, Martin; Bagger, Jonatan Ising; Strandberg, Charlotte; Kønig, Merete Juhl; Grønbæk, Henning; Becker, Ulrik; Holst, Jens J; Knop, Joachim; Gillum, Matthew Paul; Vilsbøll, Tina; Knop, Filip K.
In: European Journal of Endocrinology, Vol. 185, No. 1, 04.2021, p. 23-32.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Metabolic effects of one-week binge drinking and fast food intake during Roskilde Festival in young healthy male adults
AU - Demant, Mia
AU - Suppli, Malte Palm
AU - Foghsgaard, Signe
AU - Gether, Lise
AU - Grøndahl, Magnus Frederik Gluud
AU - Dalsgaard, Niels Bjørn
AU - Bergmann, Sigrid S
AU - Lanng, Amalie Rasmussen
AU - Gasbjerg, Lærke S
AU - Thomasen, Martin
AU - Bagger, Jonatan Ising
AU - Strandberg, Charlotte
AU - Kønig, Merete Juhl
AU - Grønbæk, Henning
AU - Becker, Ulrik
AU - Holst, Jens J
AU - Knop, Joachim
AU - Gillum, Matthew Paul
AU - Vilsbøll, Tina
AU - Knop, Filip K
PY - 2021/4
Y1 - 2021/4
N2 - AIMS/HYPOTHESIS: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (one week of binge drinking and junk food consumption) in young, healthy males.METHODS: Fourteen festival participants (FP) were studied before, during and after one week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.RESULTS: The FP group consumed more alcohol compared to their standard living conditions (2.0±3.9 vs 16.3±8.3 units/day, p<0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (320±31 vs 376±25 nmol/l×min, p=0.055) and the Matsuda index of insulin sensitivity decreased (6.2±2.4 vs 4.7±1.4, p = 0.054). AUC for glucagon during OGTT increased in the FP group (1,115±114 vs 1,599±183 pmol/l×min, p=0.003) together with fasting fibroblast growth factor 21 (FGF21) (62±30 vs 132±72 pmol/L, p<0.001), growth differentiation factor 15 (GDF5) (276±78 vs 330±83 pg/mL, p=0.009) and aspartate aminotransferase (AST) levels (37.6±6.8 vs 42.4±11 U/l, p=0.043). Four participants (29%) developed ultrasound-detectable steatosis and mean strain elastography-assessed liver stiffness increased (p=0.026) in the FP group.CONCLUSIONS/INTERPRETATION: Participation in Roskilde Festival did not affect oral glucose tolerance, but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.
AB - AIMS/HYPOTHESIS: Metabolic effects of intermittent unhealthy lifestyle in young adults are poorly studied. We investigated the gluco-metabolic and hepatic effects of participation in Roskilde Festival (one week of binge drinking and junk food consumption) in young, healthy males.METHODS: Fourteen festival participants (FP) were studied before, during and after one week's participation in Roskilde Festival. Fourteen matched controls (CTRL) who did not participate in Roskilde Festival or change their lifestyle in other ways were investigated along a similar timeline.RESULTS: The FP group consumed more alcohol compared to their standard living conditions (2.0±3.9 vs 16.3±8.3 units/day, p<0.001). CTRLs did not change their alcohol consumption. AUC for glucose during OGTT did not change in either group. C-peptide responses increased in the FP group (320±31 vs 376±25 nmol/l×min, p=0.055) and the Matsuda index of insulin sensitivity decreased (6.2±2.4 vs 4.7±1.4, p = 0.054). AUC for glucagon during OGTT increased in the FP group (1,115±114 vs 1,599±183 pmol/l×min, p=0.003) together with fasting fibroblast growth factor 21 (FGF21) (62±30 vs 132±72 pmol/L, p<0.001), growth differentiation factor 15 (GDF5) (276±78 vs 330±83 pg/mL, p=0.009) and aspartate aminotransferase (AST) levels (37.6±6.8 vs 42.4±11 U/l, p=0.043). Four participants (29%) developed ultrasound-detectable steatosis and mean strain elastography-assessed liver stiffness increased (p=0.026) in the FP group.CONCLUSIONS/INTERPRETATION: Participation in Roskilde Festival did not affect oral glucose tolerance, but was associated with a reduction in insulin sensitivity, increases in glucagon, FGF21, GDF15 and AST and lead to increased liver stiffness and, in 29% of the participants, ultrasound-detectable hepatic steatosis.
U2 - 10.1530/EJE-21-0122
DO - 10.1530/EJE-21-0122
M3 - Journal article
C2 - 33886497
VL - 185
SP - 23
EP - 32
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -
ID: 260995632