Standard
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. / Postmus, Iris; Warren, Helen R; Trompet, Stella; Arsenault, Benoit J; Avery, Christy L; Bis, Joshua C; Chasman, Daniel I; de Keyser, Catherine E; Deshmukh, Harshal A; Evans, Daniel S; Feng, QiPing; Li, Xiaohui; Smit, Roelof A J; Smith, Albert V; Sun, Fangui; Taylor, Kent D; Arnold, Alice M; Barnes, Michael R; Barratt, Bryan J; Betteridge, John; Boekholdt, S Matthijs; Boerwinkle, Eric; Buckley, Brendan M; Chen, Y-D Ida; de Craen, Anton J M; Cummings, Steven R; Denny, Joshua C; Dubé, Marie Pierre; Durrington, Paul N; Eiriksdottir, Gudny; Ford, Ian; Guo, Xiuqing; Harris, Tamara B; Heckbert, Susan R; Hofman, Albert; Hovingh, G Kees; Kastelein, John J P; Launer, Leonore J; Liu, Ching-Ti; Liu, Yongmei; Lumley, Thomas; McKeigue, Paul M; Munroe, Patricia B; Neil, Andrew; Nickerson, Deborah A; Nyberg, Fredrik; O'Brien, Eoin; O'Donnell, Christopher J; Post, Wendy; Poulter, Neil; Vasan, Ramachandran S; Rice, Kenneth; Rich, Stephen S; Rivadeneira, Fernando; Sattar, Naveed; Sever, Peter; Shaw-Hawkins, Sue; Shields, Denis C; Slagboom, P Eline; Smith, Nicholas L; Smith, Joshua D; Sotoodehnia, Nona; Stanton, Alice; Stott, David J; Stricker, Bruno H; Stürmer, Til; Uitterlinden, André G; Wei, Wei-Qi; Westendorp, Rudi G J; Whitsel, Eric A; Wiggins, Kerri L; Wilke, Russell A; Ballantyne, Christie M; Colhoun, Helen M; Cupples, L Adrienne; Franco, Oscar H; Gudnason, Vilmundur; Hitman, Graham; Palmer, Colin N A; Psaty, Bruce M; Ridker, Paul M; Stafford, Jeanette M; Stein, Charles M; Tardif, Jean-Claude; Caulfield, Mark J; Jukema, J Wouter; Rotter, Jerome I; Krauss, Ronald M.
In:
Journal of Medical Genetics, Vol. 53, No. 12, 12.2016, p. 835-845.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Postmus, I, Warren, HR, Trompet, S, Arsenault, BJ, Avery, CL, Bis, JC, Chasman, DI, de Keyser, CE, Deshmukh, HA, Evans, DS, Feng, Q, Li, X, Smit, RAJ, Smith, AV, Sun, F, Taylor, KD, Arnold, AM, Barnes, MR, Barratt, BJ, Betteridge, J, Boekholdt, SM, Boerwinkle, E, Buckley, BM, Chen, Y-DI, de Craen, AJM, Cummings, SR, Denny, JC, Dubé, MP, Durrington, PN, Eiriksdottir, G, Ford, I, Guo, X, Harris, TB, Heckbert, SR, Hofman, A, Hovingh, GK, Kastelein, JJP, Launer, LJ, Liu, C-T, Liu, Y, Lumley, T, McKeigue, PM, Munroe, PB, Neil, A, Nickerson, DA, Nyberg, F, O'Brien, E, O'Donnell, CJ, Post, W, Poulter, N, Vasan, RS, Rice, K, Rich, SS, Rivadeneira, F, Sattar, N, Sever, P, Shaw-Hawkins, S, Shields, DC, Slagboom, PE, Smith, NL, Smith, JD, Sotoodehnia, N, Stanton, A, Stott, DJ, Stricker, BH, Stürmer, T, Uitterlinden, AG, Wei, W-Q
, Westendorp, RGJ, Whitsel, EA, Wiggins, KL, Wilke, RA, Ballantyne, CM, Colhoun, HM, Cupples, LA, Franco, OH, Gudnason, V, Hitman, G, Palmer, CNA, Psaty, BM, Ridker, PM, Stafford, JM, Stein, CM, Tardif, J-C, Caulfield, MJ, Jukema, JW, Rotter, JI & Krauss, RM 2016, '
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins',
Journal of Medical Genetics, vol. 53, no. 12, pp. 835-845.
https://doi.org/10.1136/jmedgenet-2016-103966APA
Postmus, I., Warren, H. R., Trompet, S., Arsenault, B. J., Avery, C. L., Bis, J. C., Chasman, D. I., de Keyser, C. E., Deshmukh, H. A., Evans, D. S., Feng, Q., Li, X., Smit, R. A. J., Smith, A. V., Sun, F., Taylor, K. D., Arnold, A. M., Barnes, M. R., Barratt, B. J., ... Krauss, R. M. (2016).
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Journal of Medical Genetics,
53(12), 835-845.
https://doi.org/10.1136/jmedgenet-2016-103966Vancouver
Postmus I, Warren HR, Trompet S, Arsenault BJ, Avery CL, Bis JC et al.
Meta-analysis of genome-wide association studies of HDL cholesterol response to statins.
Journal of Medical Genetics. 2016 Dec;53(12):835-845.
https://doi.org/10.1136/jmedgenet-2016-103966Author
Postmus, Iris ; Warren, Helen R ; Trompet, Stella ; Arsenault, Benoit J ; Avery, Christy L ; Bis, Joshua C ; Chasman, Daniel I ; de Keyser, Catherine E ; Deshmukh, Harshal A ; Evans, Daniel S ; Feng, QiPing ; Li, Xiaohui ; Smit, Roelof A J ; Smith, Albert V ; Sun, Fangui ; Taylor, Kent D ; Arnold, Alice M ; Barnes, Michael R ; Barratt, Bryan J ; Betteridge, John ; Boekholdt, S Matthijs ; Boerwinkle, Eric ; Buckley, Brendan M ; Chen, Y-D Ida ; de Craen, Anton J M ; Cummings, Steven R ; Denny, Joshua C ; Dubé, Marie Pierre ; Durrington, Paul N ; Eiriksdottir, Gudny ; Ford, Ian ; Guo, Xiuqing ; Harris, Tamara B ; Heckbert, Susan R ; Hofman, Albert ; Hovingh, G Kees ; Kastelein, John J P ; Launer, Leonore J ; Liu, Ching-Ti ; Liu, Yongmei ; Lumley, Thomas ; McKeigue, Paul M ; Munroe, Patricia B ; Neil, Andrew ; Nickerson, Deborah A ; Nyberg, Fredrik ; O'Brien, Eoin ; O'Donnell, Christopher J ; Post, Wendy ; Poulter, Neil ; Vasan, Ramachandran S ; Rice, Kenneth ; Rich, Stephen S ; Rivadeneira, Fernando ; Sattar, Naveed ; Sever, Peter ; Shaw-Hawkins, Sue ; Shields, Denis C ; Slagboom, P Eline ; Smith, Nicholas L ; Smith, Joshua D ; Sotoodehnia, Nona ; Stanton, Alice ; Stott, David J ; Stricker, Bruno H ; Stürmer, Til ; Uitterlinden, André G ; Wei, Wei-Qi ; Westendorp, Rudi G J ; Whitsel, Eric A ; Wiggins, Kerri L ; Wilke, Russell A ; Ballantyne, Christie M ; Colhoun, Helen M ; Cupples, L Adrienne ; Franco, Oscar H ; Gudnason, Vilmundur ; Hitman, Graham ; Palmer, Colin N A ; Psaty, Bruce M ; Ridker, Paul M ; Stafford, Jeanette M ; Stein, Charles M ; Tardif, Jean-Claude ; Caulfield, Mark J ; Jukema, J Wouter ; Rotter, Jerome I ; Krauss, Ronald M. / Meta-analysis of genome-wide association studies of HDL cholesterol response to statins. In: Journal of Medical Genetics. 2016 ; Vol. 53, No. 12. pp. 835-845.
Bibtex
@article{e6ed0d705b1e40f3a582e2a287f26b50,
title = "Meta-analysis of genome-wide association studies of HDL cholesterol response to statins",
abstract = "BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation.METHODS AND RESULTS: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p<5×10(-8)) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment.CONCLUSIONS: Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.",
author = "Iris Postmus and Warren, {Helen R} and Stella Trompet and Arsenault, {Benoit J} and Avery, {Christy L} and Bis, {Joshua C} and Chasman, {Daniel I} and {de Keyser}, {Catherine E} and Deshmukh, {Harshal A} and Evans, {Daniel S} and QiPing Feng and Xiaohui Li and Smit, {Roelof A J} and Smith, {Albert V} and Fangui Sun and Taylor, {Kent D} and Arnold, {Alice M} and Barnes, {Michael R} and Barratt, {Bryan J} and John Betteridge and Boekholdt, {S Matthijs} and Eric Boerwinkle and Buckley, {Brendan M} and Chen, {Y-D Ida} and {de Craen}, {Anton J M} and Cummings, {Steven R} and Denny, {Joshua C} and Dub{\'e}, {Marie Pierre} and Durrington, {Paul N} and Gudny Eiriksdottir and Ian Ford and Xiuqing Guo and Harris, {Tamara B} and Heckbert, {Susan R} and Albert Hofman and Hovingh, {G Kees} and Kastelein, {John J P} and Launer, {Leonore J} and Ching-Ti Liu and Yongmei Liu and Thomas Lumley and McKeigue, {Paul M} and Munroe, {Patricia B} and Andrew Neil and Nickerson, {Deborah A} and Fredrik Nyberg and Eoin O'Brien and O'Donnell, {Christopher J} and Wendy Post and Neil Poulter and Vasan, {Ramachandran S} and Kenneth Rice and Rich, {Stephen S} and Fernando Rivadeneira and Naveed Sattar and Peter Sever and Sue Shaw-Hawkins and Shields, {Denis C} and Slagboom, {P Eline} and Smith, {Nicholas L} and Smith, {Joshua D} and Nona Sotoodehnia and Alice Stanton and Stott, {David J} and Stricker, {Bruno H} and Til St{\"u}rmer and Uitterlinden, {Andr{\'e} G} and Wei-Qi Wei and Westendorp, {Rudi G J} and Whitsel, {Eric A} and Wiggins, {Kerri L} and Wilke, {Russell A} and Ballantyne, {Christie M} and Colhoun, {Helen M} and Cupples, {L Adrienne} and Franco, {Oscar H} and Vilmundur Gudnason and Graham Hitman and Palmer, {Colin N A} and Psaty, {Bruce M} and Ridker, {Paul M} and Stafford, {Jeanette M} and Stein, {Charles M} and Jean-Claude Tardif and Caulfield, {Mark J} and Jukema, {J Wouter} and Rotter, {Jerome I} and Krauss, {Ronald M}",
note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/",
year = "2016",
month = dec,
doi = "10.1136/jmedgenet-2016-103966",
language = "English",
volume = "53",
pages = "835--845",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "B M J Group",
number = "12",
}
RIS
TY - JOUR
T1 - Meta-analysis of genome-wide association studies of HDL cholesterol response to statins
AU - Postmus, Iris
AU - Warren, Helen R
AU - Trompet, Stella
AU - Arsenault, Benoit J
AU - Avery, Christy L
AU - Bis, Joshua C
AU - Chasman, Daniel I
AU - de Keyser, Catherine E
AU - Deshmukh, Harshal A
AU - Evans, Daniel S
AU - Feng, QiPing
AU - Li, Xiaohui
AU - Smit, Roelof A J
AU - Smith, Albert V
AU - Sun, Fangui
AU - Taylor, Kent D
AU - Arnold, Alice M
AU - Barnes, Michael R
AU - Barratt, Bryan J
AU - Betteridge, John
AU - Boekholdt, S Matthijs
AU - Boerwinkle, Eric
AU - Buckley, Brendan M
AU - Chen, Y-D Ida
AU - de Craen, Anton J M
AU - Cummings, Steven R
AU - Denny, Joshua C
AU - Dubé, Marie Pierre
AU - Durrington, Paul N
AU - Eiriksdottir, Gudny
AU - Ford, Ian
AU - Guo, Xiuqing
AU - Harris, Tamara B
AU - Heckbert, Susan R
AU - Hofman, Albert
AU - Hovingh, G Kees
AU - Kastelein, John J P
AU - Launer, Leonore J
AU - Liu, Ching-Ti
AU - Liu, Yongmei
AU - Lumley, Thomas
AU - McKeigue, Paul M
AU - Munroe, Patricia B
AU - Neil, Andrew
AU - Nickerson, Deborah A
AU - Nyberg, Fredrik
AU - O'Brien, Eoin
AU - O'Donnell, Christopher J
AU - Post, Wendy
AU - Poulter, Neil
AU - Vasan, Ramachandran S
AU - Rice, Kenneth
AU - Rich, Stephen S
AU - Rivadeneira, Fernando
AU - Sattar, Naveed
AU - Sever, Peter
AU - Shaw-Hawkins, Sue
AU - Shields, Denis C
AU - Slagboom, P Eline
AU - Smith, Nicholas L
AU - Smith, Joshua D
AU - Sotoodehnia, Nona
AU - Stanton, Alice
AU - Stott, David J
AU - Stricker, Bruno H
AU - Stürmer, Til
AU - Uitterlinden, André G
AU - Wei, Wei-Qi
AU - Westendorp, Rudi G J
AU - Whitsel, Eric A
AU - Wiggins, Kerri L
AU - Wilke, Russell A
AU - Ballantyne, Christie M
AU - Colhoun, Helen M
AU - Cupples, L Adrienne
AU - Franco, Oscar H
AU - Gudnason, Vilmundur
AU - Hitman, Graham
AU - Palmer, Colin N A
AU - Psaty, Bruce M
AU - Ridker, Paul M
AU - Stafford, Jeanette M
AU - Stein, Charles M
AU - Tardif, Jean-Claude
AU - Caulfield, Mark J
AU - Jukema, J Wouter
AU - Rotter, Jerome I
AU - Krauss, Ronald M
N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
PY - 2016/12
Y1 - 2016/12
N2 - BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation.METHODS AND RESULTS: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p<5×10(-8)) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment.CONCLUSIONS: Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.
AB - BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation.METHODS AND RESULTS: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals. The only associations of genome-wide significance (p<5×10(-8)) were between minor alleles at the CETP locus and greater HDL-C response to statin treatment.CONCLUSIONS: Based on results from this study that included a relatively large sample size, we suggest that CETP may be the only detectable locus with common genetic variants that influence HDL-C response to statins substantially in individuals of European descent. Although CETP is known to be associated with HDL-C, we provide evidence that this pharmacogenetic effect is independent of its association with baseline HDL-C levels.
U2 - 10.1136/jmedgenet-2016-103966
DO - 10.1136/jmedgenet-2016-103966
M3 - Journal article
C2 - 27587472
VL - 53
SP - 835
EP - 845
JO - Journal of Medical Genetics
JF - Journal of Medical Genetics
SN - 0022-2593
IS - 12
ER -
