Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)
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Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). / O'Callaghan-Gordo, Cristina; Kogevinas, Manolis; Pedersen, Marie; Fthenou, Eleni; Espinosa, Ana; Tsiapa, Xristina; Chalkiadaki, Georgia; Daraki, Vasiliki; Dermitzaki, Eirini; Decordier, Ilse; Farmer, Peter B.; Georgiadis, Panagiotis; Georgiou, Vaggelis; Kyrtopoulos, Soterios A.; Merlo, Domenico Franco; Romaguera, Dora; Roumeliotaki, Theano; Sarri, Katerina; Törnqvist, Margareta; Loock, Kim Vande; von Stedingk, Hans; Kleinjans, Jos; Kirsch-Volders, Micheline; Chatzi, Leda.
In: European Journal of Nutrition, Vol. 57, No. 1, 2018, p. 209–218.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete)
AU - O'Callaghan-Gordo, Cristina
AU - Kogevinas, Manolis
AU - Pedersen, Marie
AU - Fthenou, Eleni
AU - Espinosa, Ana
AU - Tsiapa, Xristina
AU - Chalkiadaki, Georgia
AU - Daraki, Vasiliki
AU - Dermitzaki, Eirini
AU - Decordier, Ilse
AU - Farmer, Peter B.
AU - Georgiadis, Panagiotis
AU - Georgiou, Vaggelis
AU - Kyrtopoulos, Soterios A.
AU - Merlo, Domenico Franco
AU - Romaguera, Dora
AU - Roumeliotaki, Theano
AU - Sarri, Katerina
AU - Törnqvist, Margareta
AU - Loock, Kim Vande
AU - von Stedingk, Hans
AU - Kleinjans, Jos
AU - Kirsch-Volders, Micheline
AU - Chatzi, Leda
PY - 2018
Y1 - 2018
N2 - PURPOSE: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.METHODS: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).RESULTS: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.CONCLUSIONS: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.
AB - PURPOSE: The study assessed whether diet and adherence to cancer prevention guidelines during pregnancy were associated with micronucleus (MN) frequency in mothers and newborns. MN is biomarkers of early genetic effects that have been associated with cancer risk in adults.METHODS: A total of 188 mothers and 200 newborns from the Rhea cohort (Greece) were included in the study. At early-mid pregnancy, we conducted personal interviews and a validated food frequency questionnaire was completed. With this information, we constructed a score reflecting adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines on diet, physical activity and body fatness. At delivery, maternal and/or cord blood was collected to measure DNA and hemoglobin adducts of dietary origin and frequencies of MN in binucleated and mononucleated T lymphocytes (MNBN and MNMONO).RESULTS: In mothers, higher levels of red meat consumption were associated with increased MNBN frequency [2nd tertile IRR = 1.34 (1.00, 1.80), 3rd tertile IRR = 1.33 (0.96, 1.85)] and MNMONO frequency [2nd tertile IRR = 1.53 (0.84, 2.77), 3rd tertile IRR = 2.69 (1.44, 5.05)]. The opposite trend was observed for MNBN in newborns [2nd tertile IRR = 0.64 (0.44, 0.94), 3rd tertile IRR = 0.68 (0.46, 1.01)], and no association was observed with MNMONO. Increased MN frequency in pregnant women with high red meat consumption is consistent with previous knowledge.CONCLUSIONS: Our results also suggest exposure to genotoxics during pregnancy might affect differently mothers and newborns. The predictive value of MN as biomarker for childhood cancer, rather than adulthood, remains unclear. With few exceptions, the association between maternal carcinogenic exposures during pregnancy and childhood cancer or early biologic effect biomarkers remains poorly understood.
U2 - 10.1007/s00394-016-1310-1
DO - 10.1007/s00394-016-1310-1
M3 - Journal article
C2 - 27655526
VL - 57
SP - 209
EP - 218
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 1
ER -
ID: 171662749