Marine oil supplements for arthritis pain: A systematic review and meta-analysis of randomized trials

Research output: Contribution to journalReviewResearchpeer-review

Standard

Marine oil supplements for arthritis pain : A systematic review and meta-analysis of randomized trials. / Senftleber, Ninna K.; Nielsen, Sabrina M.; Andersen, Jens Rikardt; Bliddal, Henning; Tarp, Simon; Lauritzen, Lotte; Furst, Daniel E; Suarez-Almazor, Maria E; Lyddiatt, Anne; Christensen, Robin.

In: Nutrients, Vol. 42, No. 1, 42, 2017.

Research output: Contribution to journalReviewResearchpeer-review

Harvard

Senftleber, NK, Nielsen, SM, Andersen, JR, Bliddal, H, Tarp, S, Lauritzen, L, Furst, DE, Suarez-Almazor, ME, Lyddiatt, A & Christensen, R 2017, 'Marine oil supplements for arthritis pain: A systematic review and meta-analysis of randomized trials', Nutrients, vol. 42, no. 1, 42. https://doi.org/10.3390/nu9010042

APA

Senftleber, N. K., Nielsen, S. M., Andersen, J. R., Bliddal, H., Tarp, S., Lauritzen, L., ... Christensen, R. (2017). Marine oil supplements for arthritis pain: A systematic review and meta-analysis of randomized trials. Nutrients, 42(1), [42]. https://doi.org/10.3390/nu9010042

Vancouver

Senftleber NK, Nielsen SM, Andersen JR, Bliddal H, Tarp S, Lauritzen L et al. Marine oil supplements for arthritis pain: A systematic review and meta-analysis of randomized trials. Nutrients. 2017;42(1). 42. https://doi.org/10.3390/nu9010042

Author

Senftleber, Ninna K. ; Nielsen, Sabrina M. ; Andersen, Jens Rikardt ; Bliddal, Henning ; Tarp, Simon ; Lauritzen, Lotte ; Furst, Daniel E ; Suarez-Almazor, Maria E ; Lyddiatt, Anne ; Christensen, Robin. / Marine oil supplements for arthritis pain : A systematic review and meta-analysis of randomized trials. In: Nutrients. 2017 ; Vol. 42, No. 1.

Bibtex

@article{4a4c42dad8d0445db2a436f01764e85d,
title = "Marine oil supplements for arthritis pain: A systematic review and meta-analysis of randomized trials",
abstract = "Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of allmarine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95{\%} confidence interval, CI, -0.42 to -0.07; heterogeneity, I2 = 63{\%}. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95{\%} CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95{\%} CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95{\%} CI, -0.57–0.24). The evidence for using marine oil toalleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.",
keywords = "Faculty of Science, Arthritis, Marine oil, Fish oil, Joint pain, Rheumatology, Complementary medicine, Meta-analysis, Randomized controlled trial",
author = "Senftleber, {Ninna K.} and Nielsen, {Sabrina M.} and Andersen, {Jens Rikardt} and Henning Bliddal and Simon Tarp and Lotte Lauritzen and Furst, {Daniel E} and Suarez-Almazor, {Maria E} and Anne Lyddiatt and Robin Christensen",
note = "CURIS 2017 NEXS 026",
year = "2017",
doi = "10.3390/nu9010042",
language = "English",
volume = "42",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "1",

}

RIS

TY - JOUR

T1 - Marine oil supplements for arthritis pain

T2 - A systematic review and meta-analysis of randomized trials

AU - Senftleber, Ninna K.

AU - Nielsen, Sabrina M.

AU - Andersen, Jens Rikardt

AU - Bliddal, Henning

AU - Tarp, Simon

AU - Lauritzen, Lotte

AU - Furst, Daniel E

AU - Suarez-Almazor, Maria E

AU - Lyddiatt, Anne

AU - Christensen, Robin

N1 - CURIS 2017 NEXS 026

PY - 2017

Y1 - 2017

N2 - Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of allmarine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I2 = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57–0.24). The evidence for using marine oil toalleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.

AB - Arthritis patients often take fish oil supplements to alleviate symptoms, but limited evidence exists regarding their efficacy. The objective was to evaluate whether marine oil supplements reduce pain and/or improve other clinical outcomes in patients with arthritis. Six databases were searched systematically (24 February 2015). We included randomized trials of oral supplements of allmarine oils compared with a control in arthritis patients. The internal validity was assessed using the Cochrane Risk of Bias tool and heterogeneity was explored using restricted maximum of likelihood (REML)-based meta-regression analysis. Grading of Recommendations Assessment, Development and Evaluation (GRADE) was used to rate the overall quality of the evidence. Forty-two trials were included; 30 trials reported complete data on pain. The standardized mean difference (SMD) suggested a favorable effect (-0.24; 95% confidence interval, CI, -0.42 to -0.07; heterogeneity, I2 = 63%. A significant effect was found in patients with rheumatoid arthritis (22 trials; -0.21; 95% CI, -0.42 to -0.004) and other or mixed diagnoses (3 trials; -0.63; 95% CI, -1.20 to -0.06), but not in osteoarthritis patients (5 trials; -0.17; 95% CI, -0.57–0.24). The evidence for using marine oil toalleviate pain in arthritis patients was overall of low quality, but of moderate quality in rheumatoid arthritis patients.

KW - Faculty of Science

KW - Arthritis

KW - Marine oil

KW - Fish oil

KW - Joint pain

KW - Rheumatology

KW - Complementary medicine

KW - Meta-analysis

KW - Randomized controlled trial

U2 - 10.3390/nu9010042

DO - 10.3390/nu9010042

M3 - Review

C2 - 28067815

VL - 42

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 1

M1 - 42

ER -

ID: 171117520