Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. / Hansen, Justine Y; Shafiei, Golia; Markello, Ross D; Smart, Kelly; Cox, Sylvia M L; Nørgaard, Martin; Beliveau, Vincent; Wu, Yanjun; Gallezot, Jean-Dominique; Aumont, Étienne; Servaes, Stijn; Scala, Stephanie G; DuBois, Jonathan M; Wainstein, Gabriel; Bezgin, Gleb; Funck, Thomas; Schmitz, Taylor W; Spreng, R Nathan; Galovic, Marian; Koepp, Matthias J; Duncan, John S; Coles, Jonathan P; Fryer, Tim D; Aigbirhio, Franklin I; McGinnity, Colm J; Hammers, Alexander; Soucy, Jean-Paul; Baillet, Sylvain; Guimond, Synthia; Hietala, Jarmo; Bedard, Marc-André; Leyton, Marco; Kobayashi, Eliane; Rosa-Neto, Pedro; Ganz, Melanie; Knudsen, Gitte M; Palomero-Gallagher, Nicola; Shine, James M; Carson, Richard E; Tuominen, Lauri; Dagher, Alain; Misic, Bratislav.

In: Nature Neuroscience, Vol. 25, 2022, p. 1569–1581.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, JY, Shafiei, G, Markello, RD, Smart, K, Cox, SML, Nørgaard, M, Beliveau, V, Wu, Y, Gallezot, J-D, Aumont, É, Servaes, S, Scala, SG, DuBois, JM, Wainstein, G, Bezgin, G, Funck, T, Schmitz, TW, Spreng, RN, Galovic, M, Koepp, MJ, Duncan, JS, Coles, JP, Fryer, TD, Aigbirhio, FI, McGinnity, CJ, Hammers, A, Soucy, J-P, Baillet, S, Guimond, S, Hietala, J, Bedard, M-A, Leyton, M, Kobayashi, E, Rosa-Neto, P, Ganz, M, Knudsen, GM, Palomero-Gallagher, N, Shine, JM, Carson, RE, Tuominen, L, Dagher, A & Misic, B 2022, 'Mapping neurotransmitter systems to the structural and functional organization of the human neocortex', Nature Neuroscience, vol. 25, pp. 1569–1581. https://doi.org/10.1038/s41593-022-01186-3

APA

Hansen, J. Y., Shafiei, G., Markello, R. D., Smart, K., Cox, S. M. L., Nørgaard, M., Beliveau, V., Wu, Y., Gallezot, J-D., Aumont, É., Servaes, S., Scala, S. G., DuBois, J. M., Wainstein, G., Bezgin, G., Funck, T., Schmitz, T. W., Spreng, R. N., Galovic, M., ... Misic, B. (2022). Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. Nature Neuroscience, 25, 1569–1581. https://doi.org/10.1038/s41593-022-01186-3

Vancouver

Hansen JY, Shafiei G, Markello RD, Smart K, Cox SML, Nørgaard M et al. Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. Nature Neuroscience. 2022;25:1569–1581. https://doi.org/10.1038/s41593-022-01186-3

Author

Hansen, Justine Y ; Shafiei, Golia ; Markello, Ross D ; Smart, Kelly ; Cox, Sylvia M L ; Nørgaard, Martin ; Beliveau, Vincent ; Wu, Yanjun ; Gallezot, Jean-Dominique ; Aumont, Étienne ; Servaes, Stijn ; Scala, Stephanie G ; DuBois, Jonathan M ; Wainstein, Gabriel ; Bezgin, Gleb ; Funck, Thomas ; Schmitz, Taylor W ; Spreng, R Nathan ; Galovic, Marian ; Koepp, Matthias J ; Duncan, John S ; Coles, Jonathan P ; Fryer, Tim D ; Aigbirhio, Franklin I ; McGinnity, Colm J ; Hammers, Alexander ; Soucy, Jean-Paul ; Baillet, Sylvain ; Guimond, Synthia ; Hietala, Jarmo ; Bedard, Marc-André ; Leyton, Marco ; Kobayashi, Eliane ; Rosa-Neto, Pedro ; Ganz, Melanie ; Knudsen, Gitte M ; Palomero-Gallagher, Nicola ; Shine, James M ; Carson, Richard E ; Tuominen, Lauri ; Dagher, Alain ; Misic, Bratislav. / Mapping neurotransmitter systems to the structural and functional organization of the human neocortex. In: Nature Neuroscience. 2022 ; Vol. 25. pp. 1569–1581.

Bibtex

@article{6a2b042127924404b4990cf42a55d8de,

title = "Mapping neurotransmitter systems to the structural and functional organization of the human neocortex",

abstract = "Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.",

author = "Hansen, {Justine Y} and Golia Shafiei and Markello, {Ross D} and Kelly Smart and Cox, {Sylvia M L} and Martin N{\o}rgaard and Vincent Beliveau and Yanjun Wu and Jean-Dominique Gallezot and {\'E}tienne Aumont and Stijn Servaes and Scala, {Stephanie G} and DuBois, {Jonathan M} and Gabriel Wainstein and Gleb Bezgin and Thomas Funck and Schmitz, {Taylor W} and Spreng, {R Nathan} and Marian Galovic and Koepp, {Matthias J} and Duncan, {John S} and Coles, {Jonathan P} and Fryer, {Tim D} and Aigbirhio, {Franklin I} and McGinnity, {Colm J} and Alexander Hammers and Jean-Paul Soucy and Sylvain Baillet and Synthia Guimond and Jarmo Hietala and Marc-Andr{\'e} Bedard and Marco Leyton and Eliane Kobayashi and Pedro Rosa-Neto and Melanie Ganz and Knudsen, {Gitte M} and Nicola Palomero-Gallagher and Shine, {James M} and Carson, {Richard E} and Lauri Tuominen and Alain Dagher and Bratislav Misic",

note = "{\textcopyright} 2022. The Author(s).",

year = "2022",

doi = "10.1038/s41593-022-01186-3",

language = "English",

volume = "25",

pages = "1569–1581",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

AU - Hansen, Justine Y

AU - Shafiei, Golia

AU - Markello, Ross D

AU - Smart, Kelly

AU - Cox, Sylvia M L

AU - Nørgaard, Martin

AU - Beliveau, Vincent

AU - Wu, Yanjun

AU - Gallezot, Jean-Dominique

AU - Aumont, Étienne

AU - Servaes, Stijn

AU - Scala, Stephanie G

AU - DuBois, Jonathan M

AU - Wainstein, Gabriel

AU - Bezgin, Gleb

AU - Funck, Thomas

AU - Schmitz, Taylor W

AU - Spreng, R Nathan

AU - Galovic, Marian

AU - Koepp, Matthias J

AU - Duncan, John S

AU - Coles, Jonathan P

AU - Fryer, Tim D

AU - Aigbirhio, Franklin I

AU - McGinnity, Colm J

AU - Hammers, Alexander

AU - Soucy, Jean-Paul

AU - Baillet, Sylvain

AU - Guimond, Synthia

AU - Hietala, Jarmo

AU - Bedard, Marc-André

AU - Leyton, Marco

AU - Kobayashi, Eliane

AU - Rosa-Neto, Pedro

AU - Ganz, Melanie

AU - Knudsen, Gitte M

AU - Palomero-Gallagher, Nicola

AU - Shine, James M

AU - Carson, Richard E

AU - Tuominen, Lauri

AU - Dagher, Alain

AU - Misic, Bratislav

PY - 2022

Y1 - 2022

N2 - Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.

AB - Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.

U2 - 10.1038/s41593-022-01186-3

DO - 10.1038/s41593-022-01186-3

M3 - Journal article

C2 - 36303070

VL - 25

SP - 1569

EP - 1581

JO - Nature Neuroscience

JF - Nature Neuroscience

SN - 1097-6256

ER -

ID: 323803518