Managing vitamin D deficiency in inflammatory bowel disease
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- Managing vitamin D deficiency in inflammatory bowel disease
Final published version, 835 KB, PDF document
Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.
Original language | English |
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Article number | 31656565 |
Journal | Frontline Gastroenterology |
Volume | 10 |
Issue number | 4 |
Pages (from-to) | 394-400 |
Number of pages | 7 |
ISSN | 2041-4137 |
DOIs | |
Publication status | Published - 2019 |
- biologics, clinical control, inflammatory bowel disease, therapy, vitamin D
Research areas
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