Managing vitamin D deficiency in inflammatory bowel disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Managing vitamin D deficiency in inflammatory bowel disease. / Nielsen, Ole Haagen; Hansen, Thomas Irgens; Gubatan, John Mark; Jensen, Kim Bak; Rejnmark, Lars.

In: Frontline Gastroenterology, Vol. 10, No. 4, 31656565, 2019, p. 394-400.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Nielsen, OH, Hansen, TI, Gubatan, JM, Jensen, KB & Rejnmark, L 2019, 'Managing vitamin D deficiency in inflammatory bowel disease', Frontline Gastroenterology, vol. 10, no. 4, 31656565, pp. 394-400. https://doi.org/10.1136/flgastro-2018-101055

APA

Nielsen, O. H., Hansen, T. I., Gubatan, J. M., Jensen, K. B., & Rejnmark, L. (2019). Managing vitamin D deficiency in inflammatory bowel disease. Frontline Gastroenterology, 10(4), 394-400. [31656565]. https://doi.org/10.1136/flgastro-2018-101055

Vancouver

Nielsen OH, Hansen TI, Gubatan JM, Jensen KB, Rejnmark L. Managing vitamin D deficiency in inflammatory bowel disease. Frontline Gastroenterology. 2019;10(4):394-400. 31656565. https://doi.org/10.1136/flgastro-2018-101055

Author

Nielsen, Ole Haagen ; Hansen, Thomas Irgens ; Gubatan, John Mark ; Jensen, Kim Bak ; Rejnmark, Lars. / Managing vitamin D deficiency in inflammatory bowel disease. In: Frontline Gastroenterology. 2019 ; Vol. 10, No. 4. pp. 394-400.

Bibtex

@article{2f7815526e954bcaae4f16b2a6ee8590,
title = "Managing vitamin D deficiency in inflammatory bowel disease",
abstract = "Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.",
keywords = "biologics, clinical control, inflammatory bowel disease, therapy, vitamin D",
author = "Nielsen, {Ole Haagen} and Hansen, {Thomas Irgens} and Gubatan, {John Mark} and Jensen, {Kim Bak} and Lars Rejnmark",
year = "2019",
doi = "10.1136/flgastro-2018-101055",
language = "English",
volume = "10",
pages = "394--400",
journal = "Frontline Gastroenterology",
issn = "2041-4137",
publisher = "BMJ Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Managing vitamin D deficiency in inflammatory bowel disease

AU - Nielsen, Ole Haagen

AU - Hansen, Thomas Irgens

AU - Gubatan, John Mark

AU - Jensen, Kim Bak

AU - Rejnmark, Lars

PY - 2019

Y1 - 2019

N2 - Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

AB - Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.

KW - biologics

KW - clinical control

KW - inflammatory bowel disease

KW - therapy

KW - vitamin D

U2 - 10.1136/flgastro-2018-101055

DO - 10.1136/flgastro-2018-101055

M3 - Review

C2 - 31656565

AN - SCOPUS:85059769416

VL - 10

SP - 394

EP - 400

JO - Frontline Gastroenterology

JF - Frontline Gastroenterology

SN - 2041-4137

IS - 4

M1 - 31656565

ER -

ID: 212562347